Enzymatic synthesis of ligand-bearing oligonucleotides for the development of metal-responsive DNA materials
Paper
The positional and numerical effect of N6-methyladenosine in tracrRNA on the DNA cleavage activity of Cas9
The m6A-modified tracrRNA can retain Cas9-mediated DNA cleavage activity only when the modified residues are located in the tail part of the tracrRNA, which is composed of stem loops 2 and 3.
Paper
Impact of charges on the hybridization kinetics and thermal stability of PNA duplexes
Clicking-on side chains to assess the impact of charges on hybridization properties of PNA.
Purinyl N-directed aroylation of 6-arylpurine ribo- and 2′-deoxyribonucleosides, and mechanistic insights
The purinyl nitrogen atom is an effective metalation director, which in the presence of Pd(OAc)2, t-BuOOH, and aryl aldehydes, leads to acylation of the aryl ring at the C6 position of the purine.
Paper
Improved synthesis and polymerase recognition of 7-deaza-7-modified α-L-threofuranosyl guanosine analogs
Threofuranosyl nucleic acid (TNA), an artificial genetic polymer known for its nuclease resistance and acid stability, has grown in popularity as a genetically-encoded material for applications in synthetic biology and biomedicine.
Paper
Modular and automated synthesis of oligonucleotide-small molecule conjugates for cathepsin B mediated traceless release of payloads
An enzyme-cleavable dipeptide linker between an oligonucleotide and its payload tracelessly releases the payload in cells with applications in the rapidly expanding fields of oligonucleotide-drug conjugates and targeted oligonucleotide therapeutics.
Paper
Cell-resistant wavelength-shifting molecular beacons made of L-DNA and a clickable L-configured uridine
Molecular beacons prepared from L-configured building blocks using a two-fold click chemistry for dye modification show a temperature-induced fluorescence color readout.
Paper
Site-specific RNA modification via initiation of in vitro transcription reactions with m6A and isomorphic emissive adenosine analogs
Transcription reactions with excess adenosine surrogates leads to 5′-end modified transcripts, which can be ligated to diverse RNAs. By modifying a key position in a MazF RNA substrate, insight into the folding and recognition features is gained.
About this collection
This special collection marks Professor Christian Leumann's retirement, serving as a tribute to his outstanding contributions to nucleic acid chemistry and his lasting impact on the scientific community. Widely thought of as a leading figure in the synthesis of DNA, Professor Christian Leumann has helped to shape the application of oligonucleotides in medicine and pioneered some of the modifications that are in clinical trial today. This collection aims to reflect the breadth and depth of Professor Leumann’s research interests, inspiring generations of scientists to come to continue to push the boundaries of bioorganic chemistry.
This cross-journal collection in New Journal of Chemistry, Organic & Biomolecular Chemistry, RSC Advances, RSC Chemical Biology and RSC Medicinal Chemistry, guest edited by Dr Eugen Stulz (University of Southampton, UK) and Dr Marcel Hollenstein (Institut Pasteur, France), features the most recent and significant contributions to nucleic acid chemistry, with particular emphasis on synthesis, biological and medicinal applications, nanomaterials and more.
New articles will be added to the collection upon publication. Please return to this page frequently to see the collection grow.