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Themed collection 2019 Organic Chemistry Frontiers Review-type Articles

18 items
Highlight

Synthesis of aminoboronic acid derivatives: an update on recent advances

Aminoboronic acids and their derivatives are particularly useful as drugs, probes and synthons. Recent developments in their synthesis are highlighted.

Graphical abstract: Synthesis of aminoboronic acid derivatives: an update on recent advances
Highlight

19F-GEST NMR: studying dynamic interactions in host–guest systems

GEST NMR provides dynamic information on host–guest systems. It allows signal amplification of low concentrated complexes, detection of intermolecular interactions and quantification of guest exchange rates.

Graphical abstract: 19F-GEST NMR: studying dynamic interactions in host–guest systems
Open Access Highlight

Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development

The key learnings of the utilization of sulfoximines, sulfondiimines and sulfonimidamides in drug discovery at Bayer AG are shared.

Graphical abstract: Neglected sulfur(vi) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development
Review Article

Applications of sulfuryl fluoride (SO2F2) in chemical transformations

A number of novel methodologies concerning the chemical, biological and medicinal applications of sulfuryl fluoride (SO2F2) gas have dramatically improved year by year.

Graphical abstract: Applications of sulfuryl fluoride (SO2F2) in chemical transformations
Review Article

Recent advances in intramolecular C–O/C–N/C–S bond formation via C–H functionalization

This review presents the construction of C–X bonds (X = O/N/S) by using intramolecular C–H functionalization for the synthesis of heterocyclic compounds.

Graphical abstract: Recent advances in intramolecular C–O/C–N/C–S bond formation via C–H functionalization
Review Article

Recent progress in selenium-catalyzed organic reactions

Selenium-based catalysts, including organo- and inorganoselenium ones, in organic synthesis in the recent decade are reviewed.

Graphical abstract: Recent progress in selenium-catalyzed organic reactions
Review Article

Oxidation of amine α-carbon to amide: a review on direct methods to access the amide functionality

A number of methods have been adopted for the synthesis of amides; among these methods, the oxidation of an amine to an amide is growing in interest as a means to prepare this imperative functional group.

Graphical abstract: Oxidation of amine α-carbon to amide: a review on direct methods to access the amide functionality
Review Article

Alkynogenic fragmentation

Fragmentation reactions that generate alkynes in conjunction with C–C bond cleavage require special considerations but can produce high-value alkyne building blocks for organic synthesis.

Graphical abstract: Alkynogenic fragmentation
Review Article

Metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions

Recent advances in the metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions are summarized. Usually, a broad reaction scope is observed including tertiary, secondary, and primary alkyl halides, with good functional group compatibility.

Graphical abstract: Metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions
Review Article

Recent synthetic applications of α-amido sulfones as precursors of N-acylimino derivatives

α-Amido sulfones can be directly used as N-acylimine or N-acyliminium ion precursors in several synthetic processes aimed at the preparation of nitrogen containing compounds. This review collects the most relevant and practical utilizations of α-amido sulfones appeared in the literature after 2005.

Graphical abstract: Recent synthetic applications of α-amido sulfones as precursors of N-acylimino derivatives
Review Article

Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation

This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis on the mechanisms of these reactions via C–N/C–C bond formation.

Graphical abstract: Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation
Review Article

Supramolecular ligands for the extraction of lanthanide and actinide ions

A selection of supramolecular ligands designed to extract f-elements.

Graphical abstract: Supramolecular ligands for the extraction of lanthanide and actinide ions
Review Article

On the cost of academic methodologies

Synthetic methodologies can be easily compared using the Cost of Academic Methodologies (CAM) parameter, which estimates the cost of making a mole of a product.

Graphical abstract: On the cost of academic methodologies
Review Article

Recent advances in photocatalytic C–S/P–S bond formation via the generation of sulfur centered radicals and functionalization

In this review, we have focused on the recent advances in photocatalytic C–S/P–S bond formation via the generation of thioyl/sulfonyl radicals and further functionalization.

Graphical abstract: Recent advances in photocatalytic C–S/P–S bond formation via the generation of sulfur centered radicals and functionalization
Review Article

Application of dialkyl azodicarboxylate frameworks featuring multi-functional properties

The application of dialkyl azodicarboxylates as versatile reagents in Mitsunobu, oxidation, electrophilic, amination and carbonylation reactions is reviewed.

Graphical abstract: Application of dialkyl azodicarboxylate frameworks featuring multi-functional properties
Review Article

Diffusion NMR for the characterization, in solution, of supramolecular systems based on calixarenes, resorcinarenes, and other macrocyclic arenes

The use of diffusion NMR in studying calixarenes and other arene-based supramolecular systems is described, emphasizing the pivotal role played by the calixarene community in transforming the methods into a routine tool used in supramolecular chemistry.

Graphical abstract: Diffusion NMR for the characterization, in solution, of supramolecular systems based on calixarenes, resorcinarenes, and other macrocyclic arenes
Review Article

Gold-catalyzed heterocyclic syntheses through α-imino gold carbene complexes as intermediates

This review reports a comprehensive compilation of gold-catalyzed heterocyclic synthesis by using α-imino gold carbene complexes as the proposed intermediates.

Graphical abstract: Gold-catalyzed heterocyclic syntheses through α-imino gold carbene complexes as intermediates
Open Access Review Article

Progress in the synthesis of perylene bisimide dyes

Rapid progress in the synthesis of perylene bisimide dyes gave an old scaffold new life.

Graphical abstract: Progress in the synthesis of perylene bisimide dyes
18 items

About this collection

Critical reviews and highlight articles published in    Organic Chemistry Frontiers    during 2019 are collated as below for the benefit of readers.

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