Themed collection 2019 Organic Chemistry Frontiers Review-type Articles
Nickel-catalyzed enantioselective electroreductive cross-couplings
Ni-Catalyzed reductive cross-coupling of two electrophiles has evolved into a powerful means for building diverse carbon-carbon bonds in an enantioselective manner. Here we summarize the recent progress in Ni-catalyzed enantioselective electroreductive coupling reactions.
Organic micro/nanoscale materials for photonic barcodes
This review summarizes recent advances in micro/nanoscale photonic barcodes based on organic materials from the aspects of diverse optical encoding techniques.
N-Heterocyclic carbene catalysed umpolung reactions of imines approaching enantioselective synthesis
N-Heterocyclic Carbene (NHC)-catalyzed umpolung reactions of aldimines are highlighted in this article, with a special emphasis on the corresponding enantioselective transformations developed by the research groups of Lupton and Biju.
Synthesis of aminoboronic acid derivatives: an update on recent advances
Aminoboronic acids and their derivatives are particularly useful as drugs, probes and synthons. Recent developments in their synthesis are highlighted.
19F-GEST NMR: studying dynamic interactions in host–guest systems
GEST NMR provides dynamic information on host–guest systems. It allows signal amplification of low concentrated complexes, detection of intermolecular interactions and quantification of guest exchange rates.
Neglected sulfur(VI) pharmacophores in drug discovery: exploration of novel chemical space by the interplay of drug design and method development
The key learnings of the utilization of sulfoximines, sulfondiimines and sulfonimidamides in drug discovery at Bayer AG are shared.
A diversity of recently reported methodology for asymmetric imine reduction
This review describes recent developments in enantioselective imine reduction, including related substrates in which a CN bond is the target for reduction, and in situ methods.
The preparation of (4H)-imidazol-4-ones and their application in the total synthesis of natural products
The first review article summarizing known methodologies for the preparation of (4H)-imidazol-4-ones and their application in the total synthesis of imidazol-4-one containing natural products.
Recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions
In this review, we summarized recent advances in organocatalytic asymmetric oxa-Michael addition triggered cascade reactions.
Enzymatic and non-enzymatic crosslinks found in collagen and elastin and their chemical synthesis
This review summarized the enzymatic and non-enzymatic crosslinks found in collagen and elastin and their organic synthesis.
Organoselenium chemistry-based polymer synthesis
Novel synthesis of selenium containing polymers with pre-determined structures and applications thereof.
Cavity-based applications of metallo-supramolecular coordination cages (MSCCs)
This review describes cavity-based applications of cage-like SCCs such as molecular recognition and separation, stabilization of reactive species by encapsulation, as drug delivery systems and as molecular flasks.
Recent advances in nitro-involved radical reactions
Significant progress in the chemistry of nitro radicals has been witnessed in the past decades, providing efficient and rapid access to nitro-containing compounds. This review describes recent advances in nitro-involved radical reactions, and summarizes various transformations.
Applications of sulfuryl fluoride (SO2F2) in chemical transformations
A number of novel methodologies concerning the chemical, biological and medicinal applications of sulfuryl fluoride (SO2F2) gas have dramatically improved year by year.
Recent advances in intramolecular C–O/C–N/C–S bond formation via C–H functionalization
This review presents the construction of C–X bonds (X = O/N/S) by using intramolecular C–H functionalization for the synthesis of heterocyclic compounds.
Recent progress in selenium-catalyzed organic reactions
Selenium-based catalysts, including organo- and inorganoselenium ones, in organic synthesis in the recent decade are reviewed.
Oxidation of amine α-carbon to amide: a review on direct methods to access the amide functionality
A number of methods have been adopted for the synthesis of amides; among these methods, the oxidation of an amine to an amide is growing in interest as a means to prepare this imperative functional group.
Fragmentation reactions that generate alkynes in conjunction with C–C bond cleavage require special considerations but can produce high-value alkyne building blocks for organic synthesis.
Metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions
Recent advances in the metal-catalyzed radical-type transformation of unactivated alkyl halides with C–C bond formation under photoinduced conditions are summarized. Usually, a broad reaction scope is observed including tertiary, secondary, and primary alkyl halides, with good functional group compatibility.
Recent synthetic applications of α-amido sulfones as precursors of N-acylimino derivatives
α-Amido sulfones can be directly used as N-acylimine or N-acyliminium ion precursors in several synthetic processes aimed at the preparation of nitrogen containing compounds. This review collects the most relevant and practical utilizations of α-amido sulfones appeared in the literature after 2005.
Developments towards synthesis of N-heterocycles from amidines via C–N/C–C bond formation
This review focuses on the synthesis of N-heterocycles using amidines as starting materials, with an emphasis on the mechanisms of these reactions via C–N/C–C bond formation.
Supramolecular ligands for the extraction of lanthanide and actinide ions
A selection of supramolecular ligands designed to extract f-elements.
On the cost of academic methodologies
Synthetic methodologies can be easily compared using the Cost of Academic Methodologies (CAM) parameter, which estimates the cost of making a mole of a product.
Recent advances in photocatalytic C–S/P–S bond formation via the generation of sulfur centered radicals and functionalization
In this review, we have focused on the recent advances in photocatalytic C–S/P–S bond formation via the generation of thioyl/sulfonyl radicals and further functionalization.
Application of dialkyl azodicarboxylate frameworks featuring multi-functional properties
The application of dialkyl azodicarboxylates as versatile reagents in Mitsunobu, oxidation, electrophilic, amination and carbonylation reactions is reviewed.
Diffusion NMR for the characterization, in solution, of supramolecular systems based on calixarenes, resorcinarenes, and other macrocyclic arenes
The use of diffusion NMR in studying calixarenes and other arene-based supramolecular systems is described, emphasizing the pivotal role played by the calixarene community in transforming the methods into a routine tool used in supramolecular chemistry.
Gold-catalyzed heterocyclic syntheses through α-imino gold carbene complexes as intermediates
This review reports a comprehensive compilation of gold-catalyzed heterocyclic synthesis by using α-imino gold carbene complexes as the proposed intermediates.
Progress in the synthesis of perylene bisimide dyes
Rapid progress in the synthesis of perylene bisimide dyes gave an old scaffold new life.