Themed collection RSC Pharmaceutics 2024 Hot Articles

Multifaceted elements in addressing the obese population: the blood brain barrier, nano-sized drug carriers, criteria for bariatric surgery as a treatment option, and comparative portrayal of Roux-en-Y gastric bypass and vertical sleeve gastrectomy.

This review highlights current strategies to improve the anti-biofilm activity of clinically approved carbapenem-based antibiotics.

Potential applications of ultrasound in biomedicine.

Stratum corneum (SC) ablation presents a promising strategy to enhance transdermal drug delivery (TDD) by temporary removing the skin's outermost barrier facilitating improved absorption of therapeutic agents.

Native cassava starch and its derivatives have found great use in the pharmaceutical sector for the development of various novel and conventional drug delivery carriers.

This review mainly highlights the use of polymer–drug conjugates as an advanced drug delivery system to improve the treatment of AD and other neurodegenerative diseases.

Enrofloxacin release from PLGA nanocarriers was evaluated in simulated saliva and gastric fluid. AF4 and DFT analyses revealed that acidic solvent intrusion above T_g induced faster diffusive release, whereas media proteins had no significant effect.

Cell penetrating peptides (CPPs) have emerged as promising materials for the fabrication of synthetic nanovectors endowed with potential for improving the future landscape of gene therapy.

Therapeutic proteins have drawn increasing attention in the development of advanced drugs and biomedical devices, yet there are outstanding challenges for the delivery of multiple-protein therapies with customized release profiles.

Drug combinations have been shown to be highly effective in many cancer therapies but the ratios of the individual drugs must be adjusted carefully and formulated appropriately to ensure synergistic action.

A comprehensive comparison between emulsion and spray methods for the fabrication of rapamycin-loaded Ace-DEX MPs, investigating physiochemical parameters, in vitro immunosuppressive efficacy, and in vivo trafficking.

Nanomicelles prepared with a conjugate composed of Pluronic F68 and stearic acid showed enhanced cytotoxicity and improved pharmacokinetics of chrysin.

Macauba oil-loaded polymeric micelles exhibit antimigratory, antiproliferative, and cytotoxic activities in triple-negative breast cancer cells, suggesting potential as a therapeutic agent for this aggressive cancer type.

A robust delivery system for siRNA was developed based on tryptophan-intercalated polymeric micelles. These micelles enhance intracellular delivery and gene knockdown, leveraging tryptophan's role in stability and endosomal escape.

Worldwide, osteoarthritis is a significant cause of pain, disability, and socioeconomic losses.

Carvedilol nanosuspension loaded microneedles patch was formulated and characterized by particle size, zeta potential, solubility, Transmission Electron Microscopy, X-Ray Diffraction, in-vitro release and in-vivo pharmacokinetic studies

Presently, there are several challenges that need to be overcome in the development of treatments that can effectively inhibit tumor growth, prevent the spread of tumor metastases, and protect the host against recurrence.

We present an AmB-LIPOMER anchored with Acemannan (ACEM), a mannose ligand for active macrophage targeting, via mannose receptor mediated endocytosis (RME).

The antifungal activity of a small chitin-binding domain from antifungal chitinase was enhanced by the artificial lipidation with a specific alkyl chain length and structure in the presence of amphotericin B.

Eutectic formation between bupivacaine and myristic acid is denoted by significant differences in calculated spectral addition of individual components and spectrum of the binary mixture.

Schematic Representation of Synthesis and Delivery of Cytarabine loaded Fucoidan nanoparticles (CFNP).

A MOF based eutectogel with antibacterial and antioxidant attributes, along with hemocompatibility, is used for the encapsulation and sustained release of curcumin.

The characteristics of the lipid bilayer and the loading method influence the encapsulation efficacy, colloidal properties, photoactivity and stability of mono and bis-naphthalimides loaded in a liposomal carrier.

Novel alginate nanocarriers for dual iron and folate delivery: a pH-responsive system for enhanced oral bioavailability in anaemia.

Amorphous solid dispersions of ketoprofen-polyvinylpyrrolidone are prepared by five different techniques; X-ray total scattering reveals differences in their intermolecular structures.

The supramolecular aggregation of drug and co-former after co-crystal dissolution influences the taste of the material and offers a route to taste-masking of bitter drugs.

Electrostatic coupling reduces the diffusivity of octenidine 10-fold leading to a sustained release maintained for months.