Themed collection New Talent

The review discusses recent advances in electrocatalytic radical coupling reactions involving carbon-centered radical species.

This review discusses the application of genetically-encodable biosensors toward enzyme directed evolution.

Herein we disclose the chemically unique features of the pyridazinedione scaffold and how these have been applied in various bioconjugation methodologies.

A concise total synthesis of racemic mersicarpine is achieved featuring an application of a 6-exo-trig radical cyclization of a 2-indolyl radical.

A new protocol for the fluorination of various α-diazo carbonyl compounds is reported employing HF·pyr (Olah reagent). The method can be performed open-flask, is metal-free, and shows a broad scope.

In this manuscript, we report a new strategy to access α-(hetero)arylnitriles from malononitrile, a commodity chemical. The reaction proceeds through a one-pot decyanation (via transnitrilation) and subsequent nucleophilic aromatic substitution.

Sydnonimine fluorogenic probes with a high turn-on ratio were designed and synthesized, releasing near-infrared fluorescence via a strain-promoted “click-and-release” reaction.

We developed a novel copper-catalyzed benzolactone synthesis via 1,5-HAT of amidyl radicals from 2-alkylbenzamides under O₂ atmosphere.

The total synthesis of (±)-vinoxine was achieved featuring the assembly of a substituted tetrahydropyrido[1,2-a]indole skeleton through the Tf₂O-mediated Bischler–Napieralski reaction.

A visible-light-mediated oxidative C–S bond cleavage of benzyl thiols through an in situ activation strategy was developed.

Heterochiral Phe–Val self-assembles into water-channels and forms a cell-biocompatible hydrogel biomaterial.

The synthesis and evaluation of a new ATP-independent bioluminescent probe for H₂O₂ detection is described and applied toward intra- and extracellular detection in a breast cancer cell model.

Computational structural investigation (CSI) points to a new primary suspect as the general base in pistol ribozyme catalysis.

We present a general strategy for activation of N–C(S) thioamide bonds by ground-state-destabilization in the context of a full study on transamidation of thioamides with nucleophilic amines.

We investigated the photochemistry of ternary complexes of a cucurbit[8]uril host and donor–acceptor stilbene guests. We found that slow back electron transfer rates allow [2 + 2] photocycloadditions to proceed after photoinitiated charge transfer.

Studies of two organocatalyzed 1,3-dipolar cycloadditions are provided, with investigation of the elementary steps, intermediates, and transition states in terms of DFT calculations, supported by ¹H NMR monitoring, along with DIAS analysis.

Multivariate logistic regression models can be developed and utilized as a strategy to streamline the reaction optimization process.

Assembling methods using 2-azidoacrylamides having an amino group are disclosed, and they were used to synthesize 2-azidoacrylamides having a fluorosulfonyl group. We achieved consecutive click reactions using the new trivalent platform.

Sulfonated rhodamine dyes allow SNAP- and Halo-tag labelling of cell surface protein fusions. A far-red version can be used for STED nanoscopy.

A microplate reader assay to enable the characterisation of amphiphile self-assembly processes and derivation of the critical micelle concentration (CMC).

Azoarene photoswitches are versatile molecules that interconvert from their E-isomer to their Z-isomer with light.

Various small molecules containing boronic acid and urea functionalities are shown to bind selectively to the bacterial lipid PG (phosphatidylglycerol) and exert antibacterial activity through a membrane-related mechanism.