Themed collection New Talent

23 items
Review Article

Recent synthetic methods involving carbon radicals generated by electrochemical catalysis

The review discusses recent advances in electrocatalytic radical coupling reactions involving carbon-centered radical species.

Graphical abstract: Recent synthetic methods involving carbon radicals generated by electrochemical catalysis
From the themed collection: New Talent
Review Article

Enzyme directed evolution using genetically encodable biosensors

This review discusses the application of genetically-encodable biosensors toward enzyme directed evolution.

Graphical abstract: Enzyme directed evolution using genetically encodable biosensors
From the themed collection: New Talent
Open Access Review Article

The use of bromopyridazinedione derivatives in chemical biology

Herein we disclose the chemically unique features of the pyridazinedione scaffold and how these have been applied in various bioconjugation methodologies.

Graphical abstract: The use of bromopyridazinedione derivatives in chemical biology
From the themed collection: New Talent
Communication

Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization

A concise total synthesis of racemic mersicarpine is achieved featuring an application of a 6-exo-trig radical cyclization of a 2-indolyl radical.

Graphical abstract: Total synthesis of (±)-mersicarpine following a 6-exo-trig radical cyclization
From the themed collection: New Talent
Communication

H–F bond insertions into α-diazo carbonyl compounds

A new protocol for the fluorination of various α-diazo carbonyl compounds is reported employing HF·pyr (Olah reagent). The method can be performed open-flask, is metal-free, and shows a broad scope.

Graphical abstract: H–F bond insertions into α-diazo carbonyl compounds
From the themed collection: New Talent
Communication

Decyanation–(hetero)arylation of malononitriles to access α-(hetero)arylnitriles

In this manuscript, we report a new strategy to access α-(hetero)arylnitriles from malononitrile, a commodity chemical. The reaction proceeds through a one-pot decyanation (via transnitrilation) and subsequent nucleophilic aromatic substitution.

Graphical abstract: Decyanation–(hetero)arylation of malononitriles to access α-(hetero)arylnitriles
From the themed collection: New Talent
Communication

Fluorogenic sydnonimine probes for orthogonal labeling

Sydnonimine fluorogenic probes with a high turn-on ratio were designed and synthesized, releasing near-infrared fluorescence via a strain-promoted “click-and-release” reaction.

Graphical abstract: Fluorogenic sydnonimine probes for orthogonal labeling
From the themed collection: New Talent
Communication

Copper-catalyzed aerobic benzylic C(sp3)–H lactonization of 2-alkylbenzamides via N-centered radicals

We developed a novel copper-catalyzed benzolactone synthesis via 1,5-HAT of amidyl radicals from 2-alkylbenzamides under O2 atmosphere.

Graphical abstract: Copper-catalyzed aerobic benzylic C(sp3)–H lactonization of 2-alkylbenzamides via N-centered radicals
From the themed collection: New Talent
Communication

Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton via Tf2O-mediated Bischler–Napieralski reaction and stereoselective radical cyclization

The total synthesis of (±)-vinoxine was achieved featuring the assembly of a substituted tetrahydropyrido[1,2-a]indole skeleton through the Tf2O-mediated Bischler–Napieralski reaction.

Graphical abstract: Total synthesis of (±)-vinoxine: construction of the bridged pyrido[1,2-a]indole skeleton via Tf2O-mediated Bischler–Napieralski reaction and stereoselective radical cyclization
From the themed collection: New Talent
Communication

Visible-light-mediated oxidative C–S bond cleavage of benzyl thiols through in situ activation strategy

A visible-light-mediated oxidative C–S bond cleavage of benzyl thiols through an in situ activation strategy was developed.

Graphical abstract: Visible-light-mediated oxidative C–S bond cleavage of benzyl thiols through in situ activation strategy
From the themed collection: New Talent
Accepted Manuscript - Paper

Copper-catalysed one-pot hydroboration/azidation/cycloaddition

From the themed collection: New Talent
Paper

Dipeptide self-assembly into water-channels and gel biomaterial

Heterochiral Phe–Val self-assembles into water-channels and forms a cell-biocompatible hydrogel biomaterial.

Graphical abstract: Dipeptide self-assembly into water-channels and gel biomaterial
From the themed collection: New Talent
Paper

Development of an ATP-independent bioluminescent probe for detection of extracellular hydrogen peroxide

The synthesis and evaluation of a new ATP-independent bioluminescent probe for H2O2 detection is described and applied toward intra- and extracellular detection in a breast cancer cell model.

Graphical abstract: Development of an ATP-independent bioluminescent probe for detection of extracellular hydrogen peroxide
From the themed collection: New Talent
Paper

Who stole the proton? Suspect general base guanine found with a smoking gun in the pistol ribozyme

Computational structural investigation (CSI) points to a new primary suspect as the general base in pistol ribozyme catalysis.

Graphical abstract: Who stole the proton? Suspect general base guanine found with a smoking gun in the pistol ribozyme
From the themed collection: New Talent
Paper

Transamidation of thioamides with nucleophilic amines: thioamide N–C(S) activation by ground-state-destabilization

We present a general strategy for activation of N–C(S) thioamide bonds by ground-state-destabilization in the context of a full study on transamidation of thioamides with nucleophilic amines.

Graphical abstract: Transamidation of thioamides with nucleophilic amines: thioamide N–C(S) activation by ground-state-destabilization
From the themed collection: New Talent
Paper

Back electron transfer rates determine the photoreactivity of donor–acceptor stilbene complexes in a macrocyclic host

We investigated the photochemistry of ternary complexes of a cucurbit[8]uril host and donor–acceptor stilbene guests. We found that slow back electron transfer rates allow [2 + 2] photocycloadditions to proceed after photoinitiated charge transfer.

Graphical abstract: Back electron transfer rates determine the photoreactivity of donor–acceptor stilbene complexes in a macrocyclic host
From the themed collection: New Talent
Paper

Mechanistic investigation of enolate/stabilized vinylogous carbanion-mediated organocatalytic azide (3 + 2) cycloaddition reactions for the synthesis of 1,2,3-triazoles

Studies of two organocatalyzed 1,3-dipolar cycloadditions are provided, with investigation of the elementary steps, intermediates, and transition states in terms of DFT calculations, supported by 1H NMR monitoring, along with DIAS analysis.

Graphical abstract: Mechanistic investigation of enolate/stabilized vinylogous carbanion-mediated organocatalytic azide (3 + 2) cycloaddition reactions for the synthesis of 1,2,3-triazoles
From the themed collection: New Talent
Paper

A predictive and mechanistic statistical modelling workflow for improving decision making in organic synthesis and catalysis

Multivariate logistic regression models can be developed and utilized as a strategy to streamline the reaction optimization process.

Graphical abstract: A predictive and mechanistic statistical modelling workflow for improving decision making in organic synthesis and catalysis
From the themed collection: New Talent
Open Access Paper

Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group

Assembling methods using 2-azidoacrylamides having an amino group are disclosed, and they were used to synthesize 2-azidoacrylamides having a fluorosulfonyl group. We achieved consecutive click reactions using the new trivalent platform.

Graphical abstract: Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group
From the themed collection: New Talent
Open Access Paper

Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins

Sulfonated rhodamine dyes allow SNAP- and Halo-tag labelling of cell surface protein fusions. A far-red version can be used for STED nanoscopy.

Graphical abstract: Sulfonated red and far-red rhodamines to visualize SNAP- and Halo-tagged cell surface proteins
From the themed collection: New Talent
Open Access Paper

Supramolecular self-associating amphiphiles: determination of molecular self-association properties and calculation of critical micelle concentration using a high-throughput, optical density based methodology

A microplate reader assay to enable the characterisation of amphiphile self-assembly processes and derivation of the critical micelle concentration (CMC).

Graphical abstract: Supramolecular self-associating amphiphiles: determination of molecular self-association properties and calculation of critical micelle concentration using a high-throughput, optical density based methodology
From the themed collection: New Talent
Paper

Cross-conjugation controls the stabilities and photophysical properties of heteroazoarene photoswitches

Azoarene photoswitches are versatile molecules that interconvert from their E-isomer to their Z-isomer with light.

Graphical abstract: Cross-conjugation controls the stabilities and photophysical properties of heteroazoarene photoswitches
From the themed collection: New Talent
Paper

A supramolecular host for phosphatidylglycerol (PG) lipids with antibacterial activity

Various small molecules containing boronic acid and urea functionalities are shown to bind selectively to the bacterial lipid PG (phosphatidylglycerol) and exert antibacterial activity through a membrane-related mechanism.

Graphical abstract: A supramolecular host for phosphatidylglycerol (PG) lipids with antibacterial activity
From the themed collection: New Talent
23 items

About this collection

This New Talent issue aims to highlight the excellent work being carried out by early career members of our research community.

It will cover topics including organic synthesis, physical organic chemistry, supramolecular chemistry and chemical biology, and showcase the strength of research being carried out by tomorrow's leaders in the field.

Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.


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