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Themed collection Carbenes in Organic Synthesis

8 items
Accepted Manuscript - Review Article

Recent developments in photochemical reactions of diazo compounds

From the themed collection: Carbenes in Organic Synthesis
Review Article

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Cascade reactions involving a catalytic carbene/alkyne metathesis (CAM) process through a vinyl carbene intermediate provide an efficient and step-economic approach for the construction of polycyclic frameworks with structural diversity.

Graphical abstract: Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization
From the themed collection: Carbenes in Organic Synthesis
Communication

Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides

Wittig-type reactivity between iodosoarenes and phosphoranes leads to monocarbonyl iodonium ylides, which readily serve as metallocarbene precursors.

Graphical abstract: Cyclopropanation of alkenes with metallocarbenes generated from monocarbonyl iodonium ylides
From the themed collection: Carbenes in Organic Synthesis
Communication

Cp*Co(III)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds

Cp*Co(III)-catalysed selective alkylation of directed C–H bonds of arenes and heteroarenes has been accomplished employing donor–acceptor carbenes, derived from α-diazocarbonyl compounds.

Graphical abstract: Cp*Co(iii)-catalysed selective alkylation of C–H bonds of arenes and heteroarenes with α-diazocarbonyl compounds
From the themed collection: Carbenes in Organic Synthesis
Communication

Iron-catalysed carbene-transfer reactions of diazo acetonitrile

Herein we report the flow synthesis of hazardous diazo acetonitrile to enable X–H insertion reactions with a readily available iron catalyst.

Graphical abstract: Iron-catalysed carbene-transfer reactions of diazo acetonitrile
From the themed collection: Carbenes in Organic Synthesis
Paper

Intramolecular trapping of ammonium ylides with N-benzoylbenzotriazoles in aqueous medium: direct access to the pseudoindoxyl scaffold

The present work documents an operationally simple, clean and practical method for accessing the 2,2-disubstituted indolin-3-one (pseudoindoxyl) scaffold.

Graphical abstract: Intramolecular trapping of ammonium ylides with N-benzoylbenzotriazoles in aqueous medium: direct access to the pseudoindoxyl scaffold
From the themed collection: Carbenes in Organic Synthesis
Paper

Silver-catalyzed regioselective hydroamination of alkenyl diazoacetates to synthesize γ-amino acid equivalents

A simple protocol to directly access γ-amino acid derivatives by intermolecular regioselective hydroamination of trichloroethyl alkenyldiazoacetates with carbamate using a silver tetrafluoroborate catalyst is described.

Graphical abstract: Silver-catalyzed regioselective hydroamination of alkenyl diazoacetates to synthesize γ-amino acid equivalents
From the themed collection: Carbenes in Organic Synthesis
Paper

In situ generation of nitrile oxides from copper carbene and tert-butyl nitrite: synthesis of fully substituted isoxazoles

Herein, a novel [3 + 2] cycloaddition reaction of β-keto esters with nitrile oxides, which were generated in situ from copper carbene and tert-butyl nitrite, was developed effectively to give fully substituted isoxazoles.

Graphical abstract: In situ generation of nitrile oxides from copper carbene and tert-butyl nitrite: synthesis of fully substituted isoxazoles
From the themed collection: Carbenes in Organic Synthesis
8 items

About this collection

This themed collection, Guest Edited by Professor Anita Maguire, Professor Michael Doyle and Professor Jianbo Wang, highlights the latest developments in the field of carbenes as reactive intermediates or catalysts in organic synthesis. The collection includes new reactions and synthetic methodologies based on carbenes, asymmetric catalysis in carbene reactions, the application of carbenes in natural product synthesis, the application of carbenes in chemical biology, and experimental and computational analyses of the reaction mechanisms of carbene transformations.

Articles in this themed collection will be added below as soon as possible after they are published.

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