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Themed collection Mechanistic Aspects of Organic Synthesis

28 items
Review Article

A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer

There is no consensus of opinion on the origin of the large rate accelerations observed for enzyme-catalyzed hydride transfer.

Graphical abstract: A reevaluation of the origin of the rate acceleration for enzyme-catalyzed hydride transfer
From the themed collection: Mechanistic Aspects of Organic Synthesis
Communication

Photochemical generation and trapping of 3-oxacyclohexyne

The strained heterocyclic alkyne, 3-oxacyclohexyne, has been generated for the first time by a photochemical route.

Graphical abstract: Photochemical generation and trapping of 3-oxacyclohexyne
From the themed collection: Mechanistic Aspects of Organic Synthesis
Communication

Indole synthesis by palladium-catalyzed tandem allylic isomerization – furan Diels–Alder reaction

4-(Furan-2-ylamino)but-2-en-1-yl acetates are converted to substituted indoles under microwave heating in the presence of catalytic tetrakis(triphenylphosphine)palladium(0) and triisopropylphosphite.

Graphical abstract: Indole synthesis by palladium-catalyzed tandem allylic isomerization – furan Diels–Alder reaction
From the themed collection: Mechanistic Aspects of Organic Synthesis
Communication

Nucleophile dependent formation of 6- and 7-membered N-heterocycles by platinum-catalysed cyclisation of 1,5-bisallenes

Divergencies unravelled in new Pt-catalysed alkoxy- and hydroxycyclisation of N-tethered 1,5-bisallenes to give vinyl-tetrahydropyridines with alcohols and hydro-1H-azepines with water.

Graphical abstract: Nucleophile dependent formation of 6- and 7-membered N-heterocycles by platinum-catalysed cyclisation of 1,5-bisallenes
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions

Unraveling the factors affecting the regioselectivity in the ring-expansions of bicyclic aziridiniums.

Graphical abstract: Theoretical insight into the regioselective ring-expansions of bicyclic aziridinium ions
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

A computational investigation of the solvent-dependent enantioselective intramolecular Morita–Baylis–Hillman reaction of enones

A DFT study of the enantioselective organocatalytic intramolecular Morita–Baylis–Hillman (IMBH) reaction of enones under the influence of 1,1,1,3,3,3-hexafluoroisopropanol is reported. This study establishes an excellent fit between the experiment and theory.

Graphical abstract: A computational investigation of the solvent-dependent enantioselective intramolecular Morita–Baylis–Hillman reaction of enones
Open Access Paper

Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides

Bis-adducts of cyclohexa-1,4-diene with dihalocarbenes were synthesized and investigated in heterocyclization.

Graphical abstract: Substituent effects on stereoselectivity of dihalocarbene reactions with cyclohexadiene and on the reactivity of bis-dihalocyclopropanes in electrophilic nitrations en route to pyrimidine N-oxides
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

N- to C-sulfonyl photoisomerisation of dihydropyridinones: a synthetic and mechanistic study

The scope and limitations of a photoinitiated N- to C-sulfonyl migration process within a range of dihydropyridinones is assessed.

Graphical abstract: N- to C-sulfonyl photoisomerisation of dihydropyridinones: a synthetic and mechanistic study
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium

Epoxide hydrolase (EH) enzymes catalyze the hydration of racemic epoxides to yield their corresponding vicinal diols. In this work, the Bacillus megaterium epoxide hydrolase (BmEH)-mediated hydrolysis of racemic styrene oxide (rac-SO) and its para-nitro styrene oxide (rac-p-NSO) derivative are computationally investigated using density functional theory (DFT).

Graphical abstract: Exploring the origins of selectivity in soluble epoxide hydrolase from Bacillus megaterium
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Evidence of single electron transfer from the enolate anion of an N,N′-dialkyldiketopiperazine additive in BHAS coupling reactions

A designed N,N′-dialkyldiketopiperazine (DKP) provides evidence for the role of DKP additives as initiators that act by electron transfer in base-induced homolytic aromatic substitution reactions, involving coupling of haloarenes to arenes.

Graphical abstract: Evidence of single electron transfer from the enolate anion of an N,N′-dialkyldiketopiperazine additive in BHAS coupling reactions
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Computational characterization of the mechanism for the light-driven catalytic trichloromethylation of acylpyridines

DFT and DFT/MM calculations are applied to a photocatalytic enantioselective reaction and shown to be able to characterize the mechanism.

Graphical abstract: Computational characterization of the mechanism for the light-driven catalytic trichloromethylation of acylpyridines
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

The trimerization of acetylenes involves a cascade of biradical and pericyclic processes

Thorough computational studies were performed on mechanisms and energies for the thermal trimerizations of neutral or electron-rich acetylenes used as cross-linkers in organic hard-masks for lithography applications.

Graphical abstract: The trimerization of acetylenes involves a cascade of biradical and pericyclic processes
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Mechanisms for C(sp2)–Si activation of aryltrimethylsilyl groups in palladium-catalysed couplings

DFT reveals why arenes with an amide or anilide directing group react faster by C–Si than by C–H cleavage in Pd coupling reactions.

Graphical abstract: Mechanisms for C(sp2)–Si activation of aryltrimethylsilyl groups in palladium-catalysed couplings
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

The potential of pnicogen bonding for catalysis – a computational study

Computational investigations reveal that pnicogen bonding, a noncovalent interaction between the electrophilic region of a phosphorus atom and a Lewis base, can activate electrophiles in catalytic reactions.

Graphical abstract: The potential of pnicogen bonding for catalysis – a computational study
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Claisen rearrangements of benzyl vinyl ethers: theoretical investigation of mechanism, substituent effects, and regioselectivity

Theoretical calculations are reported which examine the mechanisms of Claisen rearrangements of benzyl vinyl ethers and the ways in which substituents influence reactivity and regioselectivity.

Graphical abstract: Claisen rearrangements of benzyl vinyl ethers: theoretical investigation of mechanism, substituent effects, and regioselectivity
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

The role of spin states in the catalytic mechanism of the intra- and extradiol cleavage of catechols by O2

Intradiol vs. extradiol selectivity of Fe(III)-complexes explained by spin-state consistent density functionals.

Graphical abstract: The role of spin states in the catalytic mechanism of the intra- and extradiol cleavage of catechols by O2
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

Why can a gold salt react as a base?

A new mass-spectrometry method allows monitoring the key role of the gold–gold interaction in the transformation of gold salts to bases.

Graphical abstract: Why can a gold salt react as a base?
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

Intramolecular hydrogen bonding in conformationally semi-rigid α-acylmethane derivatives: a theoretical NMR study

Experimental and computational evidence for unusual intramolecular hydrogen-bonding interactions is presented and discussed.

Graphical abstract: Intramolecular hydrogen bonding in conformationally semi-rigid α-acylmethane derivatives: a theoretical NMR study
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Laser flash photolysis of nanocrystalline α-azido-p-methoxy-acetophenone

Irradiation of nanocrystals of azide 1 results in a solid-to-solid photoreaction that forms imine 2 in high chemical yield.

Graphical abstract: Laser flash photolysis of nanocrystalline α-azido-p-methoxy-acetophenone
Paper

Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer

This work provides a comprehensive model for non-enzymatic phosphoryl transfer, as a baseline for understanding biological phosphoryl transfer reactions.

Graphical abstract: Simulating the reactions of substituted pyridinio-N-phosphonates with pyridine as a model for biological phosphoryl transfer
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Sigmatropic proton shifts: a quantum chemical study

Insights into [1,j] sigmatropic proton shifts in polyenyl anions and related conjugated systems have been revealed by quantum chemical calculations.

Graphical abstract: Sigmatropic proton shifts: a quantum chemical study
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Nitrile-assisted oxidation over oxidative-annulation: Pd-catalyzed α,β-dehydrogenation of α-cinnamyl β-keto nitriles

A palladium-catalyzed oxidation reaction is disclosed where the nitrile functionality on the substrate simply changes the course of the reaction. α-Cinnamyl β-keto nitriles provide α,β,γ,δ-diene containing β-keto nitriles with good substrate scope.

Graphical abstract: Nitrile-assisted oxidation over oxidative-annulation: Pd-catalyzed α,β-dehydrogenation of α-cinnamyl β-keto nitriles
From the themed collection: Mechanistic Aspects of Organic Synthesis
Open Access Paper

A computational study of the influence of methyl substituents on competitive ring closure to α- and β-lactones

gem-Dimethyl substitution at C3 enhances the preference for β-lactone formation from 2-chlorosuccinate but methylation at C2 almost favours α-lactone.

Graphical abstract: A computational study of the influence of methyl substituents on competitive ring closure to α- and β-lactones
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

The mechanism and regioselectivities of (NHC)nickel(II)hydride-catalyzed cycloisomerization of dienes: a computational study

Computation elucidates the mechanism and origins of regioselectivity of (NHC)Ni(II)hydride-catalyzed cycloisomerization of dienes.

Graphical abstract: The mechanism and regioselectivities of (NHC)nickel(ii)hydride-catalyzed cycloisomerization of dienes: a computational study
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

DFT studies on reactions of boroles with carbon monoxide

DFT calculations were performed to study systematically the influence of borole substituents on the reaction of boroles with carbon monoxide.

Graphical abstract: DFT studies on reactions of boroles with carbon monoxide
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

A bis(pyridyl)-N-alkylamine/Cu(I) catalyst system for aerobic alcohol oxidation

Herein a bis(pyridyl)-N-alkylamine/CuI/TEMPO/NMI catalyst system is reported for aerobic oxidation of a variety of primary alcohols to the corresponding aldehydes using readily available reagents, at room temperature and ambient air as the oxidant.

Graphical abstract: A bis(pyridyl)-N-alkylamine/Cu(i) catalyst system for aerobic alcohol oxidation
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction

The nucleophilic aromatic substitution reaction between 1-fluoro-2,4-dinitrobenzene and ethanol was examined in a series of ionic liquids across a range of mole fractions.

Graphical abstract: Rationalising the effects of ionic liquids on a nucleophilic aromatic substitution reaction
From the themed collection: Mechanistic Aspects of Organic Synthesis
Paper

A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines

A detailed computational study is presented on the reaction mechanism of ynamide-mediated condensation of carboxylic acids with amines to produce amides, which elucidates the reactivity pattern of the coupling reagent ynamide and discloses crucial bifunctional catalytic effects of the carboxylic acid substrate during aminolysis.

Graphical abstract: A computational study on the mechanism of ynamide-mediated amide bond formation from carboxylic acids and amines
From the themed collection: Mechanistic Aspects of Organic Synthesis
28 items

About this collection

This collection, guest edited by Professor Franziska Schoenebeck (RWT Aachen University) and Dr AnnMarie C O'Donoghue (Durham University) covers the mechanistic aspects of transformations in relation to organic synthesis. This includes metal-based, purely organic, theoretical and catalysis aspects as well as studies in relation to enabling technologies.

Articles in this themed collecton will be added below as soon as possible after they are published.

Please return to this page frequently to see the collection grow.

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