SCHEDULED MAINTENANCE
Nanomedicines for targeted pulmonary delivery: receptor-mediated strategy and alternatives
In this review, we provide a comprehensive overview and analysis of the current advancements in nanomedicines for targeted pulmonary delivery.
Cell membrane coated nanoparticles as a biomimetic drug delivery platform for enhancing cancer immunotherapy
Graphical abstract of CMNPs delivering different therapeutic agents for enhancing cancer immunotherapy.
Nanomedicine as a multimodal therapeutic paradigm against cancer: on the way forward in advancing precision therapy
Graphical representation of recent advancements in combinatorial anticancer treatment modalities.
Spherical nucleic acids: emerging amplifiers for therapeutic nanoplatforms
This review summarizes the amplification effect of SNAs in various combined therapy treatment strategies and highlights the recent advances of SNAs in clinical translation.
In situ peptide assemblies for bacterial infection imaging and treatment
In situ peptide assemblies have attracted considerable attention as promising alternatives in bacterial infection imaging and treatment.
Review Article
Recent advances in biomaterial designs for assisting CAR-T cell therapy towards potential solid tumor treatment
Advances in functional biomaterial designs for assisting CAR-T therapy against solid tumors.
Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer
Nanoniosome-based drug codelivery systems have become popular therapeutic instruments, demonstrating tremendous promise in cancer therapy, infection treatment, and other therapeutic domains.
A comprehensive exploration of the latest innovations for advancements in enhancing selectivity of nanozymes for theranostic nanoplatforms
This work explores cutting-edge strategies to enhance nanozyme selectivity, vital for improving diagnostics and treatments, unlocking their full theranostic potential.
Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer
Pancreatic cancer is a devastating disease with a low survival rate and limited treatment options and in this context, multifunctional graphene quantum dot-based receptor targeting, drug delivery, and bioimaging possess immense potential to cure pancreatic cancer.
Communication
Microfluidic-assisted formulation of cell membrane-camouflaged anisotropic nanostructures
This work reports the development of a high-throughput microfluidic-based platform for the formulation of cell membrane-camouflaged anisotropic gold nanostructures with minimized phagocytic uptake and enhanced cancer cell targeting.
Chitosan-coated PCL/nano-hydroxyapatite aerogel integrated with nanofiber membrane for potential use in antibacterial and guiding bone regeneration
Novel PLGA-based nanoformulation decreases doxorubicin-induced cardiotoxicity
Nanoformulations decrease systemic toxicity effects of antitumor agents.
Coaxial dual-path electrochemical biosensing and logic strategy-based detection of lung cancer-derived exosomal PD-L1
Schematic illustration of the construction of coaxial dual-path electrochemical biosensor for highly accurate recognition and detection of lung cancer-derived exosomal PD-L1.
A metal–organic cage-derived cascade antioxidant nanozyme to mitigate renal ischemia-reperfusion injury
An MOC-based cascade nanozyme with relatively definite structures was developed and it scavenged ROS to alleviate renal I/R injury.
A photo-responsive self-healing hydrogel loaded with immunoadjuvants and MoS2 nanosheets for combating post-resection breast cancer recurrence
A photo-responsive self-healing hydrogel-mediated photothermal therapy combined with immune checkpoint blockade effectively inhibited the recurrence of resected tumors, offering insights against post-resection breast cancer recurrence.
Paper
Sphingomyelinase-responsive nanomicelles for targeting atherosclerosis
Sphingomyelinase enzymatic activity destabilises iron oxide nanomicelles and promotes its accumulation in atherosclerosis in vivo.
Enhanced theranostic efficacy of epirubicin-loaded SPION@MSN through co-delivery of an anti-miR-21-expressing plasmid and ZIF-8 hybridization to target colon adenocarcinoma
The SPION@MSN-EPI/pDNA-ZIF-8-PEG-Apt nanocarrier showcases exceptional plasmid stability, drug loading, and controlled release. Its outstanding anti-tumor efficacy through targeted chemo–gene therapy is supported by its imaging traceability.
Paper
SERS nanostructures with engineered active peptides against an immune checkpoint protein
Engineered peptides on plasmonic nanostructures show a good targeting activity against the immune checkpoint programmed death ligand 1 protein (PD-L1) expressed by tumor cells. SERS signals allow quantitative evaluation of the targeting activity.
Paper
Mechanism of RGD-conjugated nanodevice binding to its target protein integrin αVβ3 by atomistic molecular dynamics and machine learning
Based on atomistic molecular dynamics simulations and machine learning approaches we unveil the binding mechanism of a cyclic-RGD-ligand activated NP (PEGylated-TiO2) to its receptor protein (integrin-αVβ3) overexpressed in many tumor cells.
Multiparametric modulation of magnetic transduction for biomolecular sensing in liquids
The transducing capacity of magnetic nanoparticles for biomarker detection in AC magnetometry lies in a number of modulating parameters. This is assessed through the variations of AC magnetic hysteresis area in absence (black colour, A0) and presence (violet colour, A) of analytes.
Oxygen self-supplying small size magnetic nanoenzymes for synergistic photodynamic and catalytic therapy of breast cancer
In this study, we developed oxygen-supplying magnetic bead nanozymes that integrate hemoglobin and encapsulate the photosensitizer curcumin, demonstrating reactive oxygen species (ROS)-induced synergistic breast cancer therapy.
A study of complexation and biological fate of polyethyleneimine-siRNA polyplexes in vitro and in vivo by fluorescence correlation spectroscopy and positron emission tomography imaging
Fluorescence correlation spectroscopy and positron emission tomography are used to study the formation of PEI siRNA polyplex nanoparticles and to trace their biological fate at cell level and in vivo.
Paper
Magnetic coagulometry: towards a new nanotechnological tool for ex vivo monitoring coagulation in human whole blood
Blood clotting disorders are among the main causes of death worldwide. Magnetic coagulometry provides a new method to test coagulation in human whole blood ex vivo, offering grounds for the improvement of current methods in research and clinic.
Paper
Functional magnetic nanoparticles for protein delivery applications: understanding protein–nanoparticle interactions
Magnetic iron oxide nanoparticles coated with PNIPMAM polymer can encapsulate protein guests and release them upon (magnetic) heating above 45 °C in the presence of competitor proteins.
Nitric oxide releasing novel amino acid-derived polymeric nanotherapeutic with anti-inflammatory properties for rapid wound tissue regeneration
The prepared PNAG NPs loaded with SNPs induce cell migration, proliferation, and angiogenesis, thus reducing inflammation and accelerating in vivo wound healing.
Paper
Poly(glycerol monomethacrylate)-encapsulated upconverting nanoparticles prepared by miniemulsion polymerization: morphology, chemical stability, antifouling properties and toxicity evaluation
Highly colloidally stable upconverting nanoparticles encapsulated in poly(glycerol monomethacrylate) by RAFT miniemulsion polymerization were non-toxic and exhibited antifouling properties.
Nanobubble-mediated cancer cell sonoporation using low-frequency ultrasound
We developed an improved sonoporation method using nanobubbles, offering potential for noninvasive uses. Our results confirmed that low frequency insonation yields sonoporation outcomes comparable to those achieved with targeted microbubbles.
Carbonized polymer dots derived from metformin and L-arginine for tumor cell membrane- and mitochondria-dual targeting therapy
We first prepared carbonized polymer dots (MA-dots) from metformin and L-arginine to target the tumor cell membrane and mitochondria for antitumor therapy.
A cascade nanoplatform for the regulation of the tumor microenvironment and combined cancer therapy
MCDGF can regulate the tumor immune microenvironment and suppress tumor growth by combined therapy, promoting the clinical application of disulfiram.
Paper
Functionalized manganese iron oxide nanoparticles: a dual potential magneto-chemotherapeutic cargo in a 3D breast cancer model
Dual magneto-chemotherapeutic effects on a 3D breast cancer model after 10, 20 and 30 min of treatment.
Anatase TiO2−x and zwitterionic porphyrin polymer-based nanocomposite for enhanced cancer photodynamic therapy
To improve the photodynamic therapy (PDT) outcomes and the ability to specifically target cancer cells of TiO2, anatase TiO2-x and zwitterionic porphyrin polymer-based nanocomposite TiO2-x@TFPC is used as the enhanced PDT agent for treating cancer.
About this collection
Guest Edited by Professor Nguyen T. K. Thanh (University College London, UK), Professor Sophie Laurent (University of Mons, Belgium), Professor Sylvie Begin-Colin (University of Strasbourg, France) and Professor Teresa Pellegrino (Italian Institute of Technology, Italy).
For nanomedicine to fill its promise, either direct intratumoral injection or active targeting with affinity ligands to achieve favourable specificity and biodistribution profiles is critical for accurate detection, monitoring and therapeutic efficacy. Such smart approaches, when translated to clinical uses, will have a great impact on the management of cancer and other diseases to improve patient survival and quality of life. However, for further clinical translation of nanoplatforms, a key step is their scale-up.
The collection focuses on the design of multifunctional hybrid nanomaterials for theranostics in biomedicine, with a focus on the scaling-up of these nanomaterials for translational studies. The scope of this collection loosely aligns with Symposium J – Design and scaling up of theranostic nanoplatforms for health: towards translational studies held in early 2023 at the Spring E-MRS meeting, and focuses on the design, synthesis and characterization of nanoparticles (including inorganic, polymers, liposomes, and dendrimers), targeting strategies, multimodal Imaging (e.g., MRI, MPI, SPECT, PET), multimodal therapy (e.g., hyperthermia, curie therapy), drug delivery, nanotoxicology, in vitro and in vivo validation of nanoplatforms combining multimodal imaging and therapies, scaling-up strategies of nanoplatform synthesis, and new synthesis processes taking into account good manufacturing practice (GMP) and environmental considerations.