Targeting and extending the eukaryotic druggable genome with natural products
The Natural Product Reports themed collection on targeting and extending the eukaryotic druggable genome with natural products is introduced by the Guest Editors, Hendrik Luesch and John B. MacMillan.
Natural products targeting the elongation phase of eukaryotic protein biosynthesis
This review highlights different mechanisms how natural products interfere with the elongation phase of eukaryotic protein biosynthesis, and it discusses therapeutic applications thereof.
Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
This highlight reviews natural products targeting of the eIF4A RNA helicase by interfering with RNA-binding or acting as interfacial inhibitors to increase RNA resident time.
Targeting eukaryotic proteases for natural products-based drug development
This review describes the role of natural products as starting points for the development of selective protease inhibitors, examples of approved agents, the clinical and preclinical pipeline, and emerging opportunities beyond classical applications.
The role of natural products in revealing NRF2 function
NRF2 is a transcription factor that is activated by many natural products for chemoprevention, but aberrant NRF2 activation can lead to disease and natural products have been used to inhibit the NRF2 pathway.
Natural products as modulators of eukaryotic protein secretion
This highlight reviews functions and therapeutic potential of diverse natural products that target different components of the mammalian protein secretory pathway.
Contributions of natural products to ion channel pharmacology
Natural products harnessed from the diverse universe of compounds within the bioenvironment are being used to modulate ion channels, a vast super-family of membrane proteins that play critical physiological roles in excitable and non-excitable cells.
Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane
This review article focuses on natural products that bind to eukaryotic membrane lipids, and includes clinically important molecules and key research tools. How their mechanism was unveiled, and how they are used in research are also mentioned.
Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
Chronic, low-grade inflammation is linked to aging and has been termed “inflammaging”.
Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products
This review describes natural products that target the cytoskeleton, including microtubules, actin, intermediate filaments, and septins, highlighting their utility for the treatment of human disease.
Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach
This review presents examples that illustrate the effectiveness of using a chemical genetics approach for the discovery of biologically active marine natural products and their molecular targets.
About this collection
This themed issue is Guest Edited by Professor Hendrik Luesch and Professor John MacMillan