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Themed collection Targeting and extending the eukaryotic druggable genome with natural products

11 items
Editorial

Targeting and extending the eukaryotic druggable genome with natural products

The Natural Product Reports themed collection on targeting and extending the eukaryotic druggable genome with natural products is introduced by the Guest Editors, Hendrik Luesch and John B. MacMillan.

Graphical abstract: Targeting and extending the eukaryotic druggable genome with natural products
Highlight

Natural products targeting the elongation phase of eukaryotic protein biosynthesis

This review highlights different mechanisms how natural products interfere with the elongation phase of eukaryotic protein biosynthesis, and it discusses therapeutic applications thereof.

Graphical abstract: Natural products targeting the elongation phase of eukaryotic protein biosynthesis
Highlight

Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products

This highlight reviews natural products targeting of the eIF4A RNA helicase by interfering with RNA-binding or acting as interfacial inhibitors to increase RNA resident time.

Graphical abstract: Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products
Review Article

Targeting eukaryotic proteases for natural products-based drug development

This review describes the role of natural products as starting points for the development of selective protease inhibitors, examples of approved agents, the clinical and preclinical pipeline, and emerging opportunities beyond classical applications.

Graphical abstract: Targeting eukaryotic proteases for natural products-based drug development
Review Article

The role of natural products in revealing NRF2 function

NRF2 is a transcription factor that is activated by many natural products for chemoprevention, but aberrant NRF2 activation can lead to disease and natural products have been used to inhibit the NRF2 pathway.

Graphical abstract: The role of natural products in revealing NRF2 function
Open Access Review Article

Natural products as modulators of eukaryotic protein secretion

This highlight reviews functions and therapeutic potential of diverse natural products that target different components of the mammalian protein secretory pathway.

Graphical abstract: Natural products as modulators of eukaryotic protein secretion
Review Article

Contributions of natural products to ion channel pharmacology

Natural products harnessed from the diverse universe of compounds within the bioenvironment are being used to modulate ion channels, a vast super-family of membrane proteins that play critical physiological roles in excitable and non-excitable cells.

Graphical abstract: Contributions of natural products to ion channel pharmacology
Review Article

Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane

This review article focuses on natural products that bind to eukaryotic membrane lipids, and includes clinically important molecules and key research tools. How their mechanism was unveiled, and how they are used in research are also mentioned.

Graphical abstract: Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane
Review Article

Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease

Chronic, low-grade inflammation is linked to aging and has been termed “inflammaging”.

Graphical abstract: Dietary natural products as epigenetic modifiers in aging-associated inflammation and disease
Review Article

Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products

This review describes natural products that target the cytoskeleton, including microtubules, actin, intermediate filaments, and septins, highlighting their utility for the treatment of human disease.

Graphical abstract: Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products
Review Article

Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach

This review presents examples that illustrate the effectiveness of using a chemical genetics approach for the discovery of biologically active marine natural products and their molecular targets.

Graphical abstract: Biologically active marine natural products and their molecular targets discovered using a chemical genetics approach
11 items

About this collection

This themed issue is Guest Edited by Professor Hendrik Luesch and Professor John MacMillan

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