Issue 5, 2020

Natural products as modulators of eukaryotic protein secretion


Covering: up to the end of 2019

Diverse natural product small molecules have allowed critical insights into processes that govern eukaryotic cells' ability to secrete cytosolically synthesized secretory proteins into their surroundings or to insert newly synthesized integral membrane proteins into the lipid bilayer of the endoplasmic reticulum. In addition, many components of the endoplasmic reticulum, required for protein homeostasis or other processes such as lipid metabolism or maintenance of calcium homeostasis, are being investigated for their potential in modulating human disease conditions such as cancer, neurodegenerative conditions and diabetes. In this review, we cover recent findings up to the end of 2019 on natural products that influence protein secretion or impact ER protein homeostasis, and serve as powerful chemical tools to understand protein flux through the mammalian secretory pathway and as leads for the discovery of new therapeutics.

Graphical abstract: Natural products as modulators of eukaryotic protein secretion

Article information

Article type
Review Article
06 Nov 2019
First published
18 Feb 2020
This article is Open Access
Creative Commons BY license

Nat. Prod. Rep., 2020,37, 717-736

Natural products as modulators of eukaryotic protein secretion

H. Luesch and V. O. Paavilainen, Nat. Prod. Rep., 2020, 37, 717 DOI: 10.1039/C9NP00066F

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