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Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products

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Abstract

Covering: up to 2019

Pharmacological targeting of eukaryotic mRNA translation initiation is a promising approach for cancer therapy, since several signaling pathways that are commonly deregulated during tumor progression converge on this process. The DEAD-box helicase, eukaryotic initiation factor (eIF) 4A, is essential for translation initiation and facilitates the loading of the 43S pre-initiation complex onto mRNAs. Hippuristanol, rocaglates, and pateamine A are natural products that each target eIF4A by interfering with the helicase's RNA-binding activity in distinct manners. They exert a selective change in gene expression that results in potent anti-tumorigenic activity in pre-clinical studies. This review will provide an update on the molecular mechanisms of action of these natural products.

Graphical abstract: Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products

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Publication details

The article was received on 13 Sep 2019 and first published on 29 Nov 2019


Article type: Highlight
DOI: 10.1039/C9NP00052F
Nat. Prod. Rep., 2020, Advance Article

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    Selective targeting of the DEAD-box RNA helicase eukaryotic initiation factor (eIF) 4A by natural products

    L. Shen and J. Pelletier, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00052F

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