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Themed collection Engineering of cell factories for the production of natural products

12 items
Cover

Front cover

Graphical abstract: Front cover
Cover

Inside front cover

Graphical abstract: Inside front cover
Editorial

Engineering of cell factories for the production of natural products

The Natural Product Reports themed issue on Engineering of cell factories for the production of natural products is introduced by the Guest Editor, Tilmann Weber.

Graphical abstract: Engineering of cell factories for the production of natural products
Open Access Viewpoint

Cell factory engineering for improved production of natural products

Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors.

Graphical abstract: Cell factory engineering for improved production of natural products
Open Access Highlight

Editing streptomycete genomes in the CRISPR/Cas9 age

This article reviews CRISPR/Cas9-based toolkits available to investigate natural product biosynthesis and regulation in streptomycete bacteria.

Graphical abstract: Editing streptomycete genomes in the CRISPR/Cas9 age
Review Article

Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites

Challenges and advances in genetic manipulation of actinomycetes.

Graphical abstract: Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites
Review Article

Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies

This review covers the recent advances in molecular tools and strategies for studies and use of natural products from marine Proteobacteria.

Graphical abstract: Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies
Review Article

Applied evolution: phylogeny-based approaches in natural products research

Here we highlight how phylogenetic analyses can be used to facilitate natural product discovery and structure elucidation.

Graphical abstract: Applied evolution: phylogeny-based approaches in natural products research
Review Article

Heterologous production of small molecules in the optimized Streptomyces hosts

The genome mining of streptomycetes has revealed their great biosynthetic potential to produce novel natural products.

Graphical abstract: Heterologous production of small molecules in the optimized Streptomyces hosts
Open Access Review Article

Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines

This review highlights recent advancements in engineering biosynthetic assembly lines and new computational tools that aid in parts search, assembly line engineering, and refinement.

Graphical abstract: Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines
Review Article

Genetic platforms for heterologous expression of microbial natural products

This review covers current genetic technologies for accessing and manipulating natural product biosynthetic gene clusters through heterologous expression.

Graphical abstract: Genetic platforms for heterologous expression of microbial natural products
Review Article

CRISPR/Cas-based genome engineering in natural product discovery

This review summarizes the current state of the art of CRISPR/Cas-based genome editing technologies for natural product producers.

Graphical abstract: CRISPR/Cas-based genome engineering in natural product discovery
12 items

About this collection

This themed issue is Guest Edited by Professor Tilmann Weber

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