Front cover
Inside front cover
Engineering of cell factories for the production of natural products
The Natural Product Reports themed issue on Engineering of cell factories for the production of natural products is introduced by the Guest Editor, Tilmann Weber.
Viewpoint
Cell factory engineering for improved production of natural products
Natural product biosynthesis is inherently linked with the primary metabolism in terms of providing precursors and co-factors.
Highlight
Editing streptomycete genomes in the CRISPR/Cas9 age
This article reviews CRISPR/Cas9-based toolkits available to investigate natural product biosynthesis and regulation in streptomycete bacteria.
Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites
Challenges and advances in genetic manipulation of actinomycetes.
Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies
This review covers the recent advances in molecular tools and strategies for studies and use of natural products from marine Proteobacteria.
Applied evolution: phylogeny-based approaches in natural products research
Here we highlight how phylogenetic analyses can be used to facilitate natural product discovery and structure elucidation.
Heterologous production of small molecules in the optimized Streptomyces hosts
The genome mining of streptomycetes has revealed their great biosynthetic potential to produce novel natural products.
Review Article
Computer-aided re-engineering of nonribosomal peptide and polyketide biosynthetic assembly lines
This review highlights recent advancements in engineering biosynthetic assembly lines and new computational tools that aid in parts search, assembly line engineering, and refinement.
Genetic platforms for heterologous expression of microbial natural products
This review covers current genetic technologies for accessing and manipulating natural product biosynthetic gene clusters through heterologous expression.
CRISPR/Cas-based genome engineering in natural product discovery
This review summarizes the current state of the art of CRISPR/Cas-based genome editing technologies for natural product producers.
About this collection
This themed issue is Guest Edited by Professor Tilmann Weber