The ambruticins and jerangolids – chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates
The title compounds stand out for their remarkable biosynthetic pathways and an attractive antifungal activity profile. Their chemistry and biology is summarised along with an outlook on chemoenzymatic synthesis as an approach to derivative libraries.
Engineering biosynthetic enzymes for industrial natural product synthesis
This review describes examples of the broadening industrial relevance of engineered secondary metabolism enzymes, natural products and analogs being made with these enzymes, and technology improvements that have enabled their development since 1999.
Total synthesis of alkaloids using both chemical and biochemical methods
A chemoenzymatic approach to synthesize structurally complex natural alkaloids (tetrahydroisoquinoline antibiotics, indole diterpenes, and monoterpene indole alkaloids) has been reviewed.
Nature-driven approaches to non-natural terpene analogues
The reactions catalysed by terpene synthases belong to the most complex and fascinating cascade-type transformations in Nature.
Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis
This review highlights recent chemoenzymatic syntheses of natural products that feature strategic applications of oxidative transformations with Fe/αKG enzymes.
About this collection
This themed issue is Guest Edited by Professor Tobias Gulder and Professor Bradley Moore