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Themed collection Enzymes in natural product total synthesis

5 items
Review Article

The ambruticins and jerangolids – chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates

The title compounds stand out for their remarkable biosynthetic pathways and an attractive antifungal activity profile. Their chemistry and biology is summarised along with an outlook on chemoenzymatic synthesis as an approach to derivative libraries.

Graphical abstract: The ambruticins and jerangolids – chemistry, biology and chemoenzymatic synthesis of potent antifungal drug candidates
From the themed collection: Enzymes in natural product total synthesis
Review Article

Engineering biosynthetic enzymes for industrial natural product synthesis

This review describes examples of the broadening industrial relevance of engineered secondary metabolism enzymes, natural products and analogs being made with these enzymes, and technology improvements that have enabled their development since 1999.

Graphical abstract: Engineering biosynthetic enzymes for industrial natural product synthesis
From the themed collection: Enzymes in natural product total synthesis
Review Article

Total synthesis of alkaloids using both chemical and biochemical methods

A chemoenzymatic approach to synthesize structurally complex natural alkaloids (tetrahydroisoquinoline antibiotics, indole diterpenes, and monoterpene indole alkaloids) has been reviewed.

Graphical abstract: Total synthesis of alkaloids using both chemical and biochemical methods
From the themed collection: Enzymes in natural product total synthesis
Review Article

Nature-driven approaches to non-natural terpene analogues

The reactions catalysed by terpene synthases belong to the most complex and fascinating cascade-type transformations in Nature.

Graphical abstract: Nature-driven approaches to non-natural terpene analogues
From the themed collection: Enzymes in natural product total synthesis
Review Article

Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis

This review highlights recent chemoenzymatic syntheses of natural products that feature strategic applications of oxidative transformations with Fe/αKG enzymes.

Graphical abstract: Harnessing the biocatalytic potential of iron- and α-ketoglutarate-dependent dioxygenases in natural product total synthesis
From the themed collection: Enzymes in natural product total synthesis
5 items

About this collection

This themed issue is Guest Edited by Professor Tobias Gulder and Professor Bradley Moore

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