Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Engineering biosynthetic enzymes for industrial natural product synthesis

Author affiliations

Abstract

Covering: 2000 to 2020

Natural products and their derivatives are commercially important medicines, agrochemicals, flavors, fragrances, and food ingredients. Industrial strategies to produce these structurally complex molecules encompass varied combinations of chemical synthesis, biocatalysis, and extraction from natural sources. Interest in engineering natural product biosynthesis began with the advent of genetic tools for pathway discovery. Genes and strains can now readily be synthesized, mutated, recombined, and sequenced. Enzyme engineering has succeeded commercially due to the development of genetic methods, analytical technologies, and machine learning algorithms. Today, engineered biosynthetic enzymes from organisms spanning the tree of life are used industrially to produce diverse molecules. These biocatalytic processes include single enzymatic steps, multienzyme cascades, and engineered native and heterologous microbial strains. This review will describe how biosynthetic enzymes have been engineered to enable commercial and near-commercial syntheses of natural products and their analogs.

Graphical abstract: Engineering biosynthetic enzymes for industrial natural product synthesis

Back to tab navigation

Article information


First published
04 May 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Review Article

Engineering biosynthetic enzymes for industrial natural product synthesis

S. Galanie, D. Entwistle and J. Lalonde, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/C9NP00071B

Social activity

Search articles by author

Spotlight

Advertisements