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Themed collection Metallomics 2017 Most Downloaded Articles

10 items
Open Access Perspective

The workings of ferritin: a crossroad of opinions

Widely divergent views emerge on the central steps in the uptake, catalytic oxidation, and transfer of iron ions by ferritin.

Graphical abstract: The workings of ferritin: a crossroad of opinions
From the themed collection: Iron in Biology
Open Access Minireview

Iron homeostasis in plants – a brief overview

Iron plays a crucial role in biochemistry and is an essential micronutrient for plants and humans alike. Recent progress in the field has led to a better understanding of iron homeostasis in plants, and aided the production of high iron crops for improved human nutrition.

Graphical abstract: Iron homeostasis in plants – a brief overview
From the themed collection: Recent Review Articles
Minireview

Methanobactins: from genome to function

Recent advances in the biosynthesis, regulation, and transport of methanobactin, a ribosomally produced, post-translationally modified copper-binding natural product.

Graphical abstract: Methanobactins: from genome to function
From the themed collection: Recent Review Articles
Tutorial Review

Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research

Mass spectrometry imaging is being increasingly used in metal-based anticancer drug development to study elemental and/or molecular drug distributions in different biological systems.

Graphical abstract: Application of imaging mass spectrometry approaches to facilitate metal-based anticancer drug research
From the themed collection: Recent Review Articles
Critical Review

Selenium in the prevention of atherosclerosis and its underlying mechanisms

Selenium and selenoproteins may prevent atherosclerosis by blocking many key events in the development of atherosclerosis.

Graphical abstract: Selenium in the prevention of atherosclerosis and its underlying mechanisms
From the themed collection: Recent Review Articles
Paper

Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor

A new fluorescence-based assay reveals that the affinities of Staphylococcus aureus IsdG and IsdI for heme are 2–3 orders of magnitude greater than previously realized.

Graphical abstract: Tight binding of heme to Staphylococcus aureus IsdG and IsdI precludes design of a competitive inhibitor
From the themed collection: Metallomics 2017 Most Downloaded Articles
Open Access Paper

Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling

Many important carcinogenesis-related signalling pathways are activated downstream of zinc channel ZIP7-mediated zinc store release.

Graphical abstract: Phosphorylation of zinc channel ZIP7 drives MAPK, PI3K and mTOR growth and proliferation signalling
From the themed collection: Metallomics 2017 Most Downloaded Articles
Open Access Paper

Comparative studies of oxaliplatin-based platinum(IV) complexes in different in vitro and in vivo tumor models

New perspectives for the development of platinum(IV) prodrugs of the anticancer agent oxaliplatin, combining bioreductive properties and immunogenic aspects, are shown.

Graphical abstract: Comparative studies of oxaliplatin-based platinum(iv) complexes in different in vitro and in vivo tumor models
Open Access Paper

Defining the human copper proteome and analysis of its expression variation in cancers

Differential gene expression analysis of TCGA RNAseq data for the human copper proteome unravels its potential involvement in various types of cancers.

Graphical abstract: Defining the human copper proteome and analysis of its expression variation in cancers
Paper

Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans

Select metal-binding agents form strong, lipophilic complexes with copper(II) that alter the cellular metal status of the opportunistic fungal pathogen Cryptococcus neoformans and demonstrate copper-dependent antifungal activity.

Graphical abstract: Chemical and functional properties of metal chelators that mobilize copper to elicit fungal killing of Cryptococcus neoformans
10 items

About this collection

This themed collection features the top 10 most downloaded articles published in Metallomics in 2017. Congratulations to all of the authors whose articles have been featured.

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