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Issue 6, 2017
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The workings of ferritin: a crossroad of opinions

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Abstract

Biochemistry of the essential element iron is complicated by radical chemistry associated with Fe(II) ions and by the extremely low solubility of the Fe(III) ion in near-neutral water. To mitigate these problems cells from all domains of life synthesize the protein ferritin to take up and oxidize Fe(II) and to form a soluble storage of Fe(III) from which iron can be made available for physiology. A long history of studies on ferritin has not yet resulted in a generally accepted mechanism of action of this enzyme. In fact strong disagreement exists between extant ideas on several key steps in the workings of ferritin. The scope of this review is to explain the experimental background of these controversies and to indicate directions towards their possible resolution.

Graphical abstract: The workings of ferritin: a crossroad of opinions

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Article information


Submitted
19 Apr 2017
Accepted
25 May 2017
First published
31 May 2017

This article is Open Access

Metallomics, 2017,9, 595-605
Article type
Perspective

The workings of ferritin: a crossroad of opinions

W. R. Hagen, P. Hagedoorn and K. Honarmand Ebrahimi, Metallomics, 2017, 9, 595
DOI: 10.1039/C7MT00124J

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