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Themed collection Molecular BioSystems Emerging Investigators 2012

19 items
Profile

Emerging investigators contributors 2012

Editor Harpal Minhas introduces this themed issue and presents the profiles of the contributing authors.

Graphical abstract: Emerging investigators contributors 2012
Opinion

Towards high throughput metabolic flux analysis in plants

Metabolic flux analysis in plants is currently a low-throughput method. This opinion article suggests strategies for shifting towards high throughput.

Graphical abstract: Towards high throughput metabolic flux analysis in plants
Review Article

Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes

This review covers the key developments in the quantitative genetics and network biology of the metabolome to deliver personalized medicine.

Graphical abstract: Metabolome 2.0: quantitative genetics and network biology of metabolic phenotypes
Review Article

Robustness analysis of cellular systems using the genetic tug-of-war method

In this review we explain the current progress in robustness measurements in vivo using the gTOW method.

Graphical abstract: Robustness analysis of cellular systems using the genetic tug-of-war method
Review Article

Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders

Oxidative stress is one of the most common alterations among psychiatric disorders.

Graphical abstract: Combining redox-proteomics and epigenomics to explain the involvement of oxidative stress in psychiatric disorders
Review Article

Chemoselective hydroxyl group transformation: an elusive target

Development of chemoselective transformations of the hydroxyl moiety is essential to the study of biological processes and the synthesis of complex natural products, but remains a challenging goal.

Graphical abstract: Chemoselective hydroxyl group transformation: an elusive target
Review Article

Engineering ecosystems and synthetic ecologies

Emerging advances in systems and synthetic biology enable design, synthesis, and construction of complex consortia of cells toward programmable ecosystems.

Graphical abstract: Engineering ecosystems and synthetic ecologies
Communication

Intramolecular three-colour single pair FRET of intrinsically disordered proteins with increased dynamic range

Triple-colour labelling combined with a measurement and analysis scheme allows us to simultaneously study multiple regions within single intrinsically disordered proteins.

Graphical abstract: Intramolecular three-colour single pair FRET of intrinsically disordered proteins with increased dynamic range
Communication

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

Probe BI-BODIPY, derived from polo-like kinase inhibitor BI2536, permits imaging of its kinase targets by fluorescence microscopy.

Graphical abstract: Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy
Communication

Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements

Signal sequence coding regions can only promote nuclear mRNA export when they are present near the 5′ end of the transcript.

Graphical abstract: Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements
Paper

Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress

Reactive Oxygen Species (ROS) are a natural by-product of cellular growth and proliferation, and are required for fundamental processes such as protein-folding and signal transduction.

Graphical abstract: Differential RNAi screening provides insights into the rewiring of signalling networks during oxidative stress
Paper

The Core Diseasome

Using H. sapiens protein–protein interaction network for computational isolation of topologically and functionally homogeneous “driver topology” enriched in disease genes, drug targets and driver genes.

Graphical abstract: The Core Diseasome
Paper

LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes

LASSO regression on a tissue specific transcriptomic dataset is used to identify novel candidate genes in Arabidopsis seed mucilage biosynthesis. One candidate transcription factor has been described in detail and it shows a similar phenotype as the “bait” gene that was used.

Graphical abstract: LASSO modeling of the Arabidopsis thaliana seed/seedling transcriptome: a model case for detection of novel mucilage and pectin metabolism genes
Paper

A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae

Our work illuminates the cellular circuitry that controls a novel synergy between two clinically important molecules, cyclosporin A and micafungin, and supports the utility of chemogenomic assays for elucidating mechanisms of drug synergy.

Graphical abstract: A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae
Paper

Identifying functional links between genes by evolutionary transcriptomics

We introduce a method by which pairs of genes are identified as functionally related when their expression profiles are more similar within species than the conservation across species.

Graphical abstract: Identifying functional links between genes by evolutionary transcriptomics
Paper

Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data

We analyzed multi-omics data for wild-type and ΔarcA mutant Escherichia coli cultured under nitrate conditions.

Graphical abstract: Metabolic regulation analysis of wild-type and arcA mutant Escherichia coli under nitrate conditions using different levels of omics data
Paper

Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance

Lipoprotein fractions in human blood have distinct profiles of polar metabolites, which differentially associate with insulin resistance.

Graphical abstract: Metabolomic analysis of polar metabolites in lipoprotein fractions identifies lipoprotein-specific metabolic profiles and their association with insulin resistance
Paper

A compendium of inborn errors of metabolism mapped onto the human metabolic network

The expansion of a human metabolic network by acylcarnitine metabolic pathways enabled the assembly of a comprehensive compendium of inborn errors of metabolism (IEMs) and its use for classification, topological, and functional analysis.

Graphical abstract: A compendium of inborn errors of metabolism mapped onto the human metabolic network
Paper

The spectral networks paradigm in high throughput mass spectrometry

Spectral networks algorithms transform the paradigm for analysis of tandem mass spectra by finding and jointly interpreting spectra from related molecules, regardless of the structure or class of molecules.

Graphical abstract: The spectral networks paradigm in high throughput mass spectrometry
19 items

About this collection

Molecular BioSystems is delighted to publish our fifth themed issue dedicated to the work of new and emerging investigators whose research in chemical biology interfaces with the -omic sciences and systems biology.

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