Themed collection Italian Proteomics Association, 2014
One medicine – one health – one biology and many proteins: proteomics on the verge of the One Health approach
The One Health approach recognizes the necessity for global thinking between animals, environment and humans as a new paradigm for healthcare. A mythological Chiron can represent the integrated body of evidence of proteomics investigations.
Are proteins a redundant ontology? Epistemological limitations in the analysis of multistate species
Do proteins really exist? Post-translational modification data depositions represent an insurmountable epistemological challenge. A framework to describe “proteins” as metabolic pathways or networks, in a conceptual continuum with metabolites, is proposed.
Live cell interactome of the human voltage dependent anion channel 3 (VDAC3) revealed in HeLa cells by affinity purification tag technique
In higher eukaryotes three different VDAC genes encode three homologous proteins which do not show the same activity.
The intrinsic disorder status of the human hepatitis C virus proteome
We showed that intrinsically disordered regions are common in the human hepatitis C virus proteins and possess numerous important functions.
Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis
A combination of two-dimensional electrophoresis and shotgun proteomics reveals mitochondrial proteolytic activation after dopamine overload.
Identification of potential pathways involved in the induction of cell cycle arrest and apoptosis by a new 4-arylidene curcumin analogue T63 in lung cancer cells: a comparative proteomic analysis
This study clarified the anti-tumor mechanisms of T63 and provided evidence for the development of T63 as a potential anti-tumor agent.
Analysis of the mitochondrial proteome of cybrid cells harbouring a truncative mitochondrial DNA mutation in respiratory complex I
Transmitochondrial cytoplasmic hybrids (cybrids) are well established model systems to reveal the effects of mitochondrial DNA (mtDNA) mutations on cell metabolism excluding the interferences of a different nuclear background.
Proteomics and phosphoproteomics provide insights into the mechanism of action of a novel pyrazolo[3,4-d]pyrimidine Src inhibitor in human osteosarcoma
2-DE to uncover the molecular mechanism of Src inhibitor.
Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach
This is a non-hypothesis-based proteomic study to identify potential specific disease-related biomarkers in acutely psychotic bipolar disorder.
Selenium effects on the metabolism of a Se-metabolizing Lactobacillus reuteri: analysis of envelope-enriched and extracellular proteomes
Fixation of selenium by Lactobacillus reuteri Lb2 BM DSM 16143 into secreted proteins as selenocysteine.
Protective effects of the neuropeptides PACAP, substance P and the somatostatin analogue octreotide in retinal ischemia: a metabolomic analysis
Ischemia is a primary cause of neuronal death in retinal diseases and the somatostatin subtype receptor 2 agonist octreotide (OCT) is known to decrease ischemia-induced retinal cell death.
Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma
A noninvasive marker for primary aldosteronism subtype definition was indicated by urinary proteomics.
Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells
The antiproliferative and differentiation potential of anthocyanin-rich strawberry fruit crude extracts (SE) were investigated on B16-F10 murine melanoma cells.
Differential protein profile in sexed bovine semen: shotgun proteomics investigation
Proteomic characterization of differential protein profile of X- and Y-chromosome bearing sperm cells in Bos taurus species.
Rapid in vitro protein synthesis pipeline: a promising tool for cost-effective protein array design
Simple and rapid design of in house built protein arrays.
About this collection
Molecular BioSystems is delighted to present this collection of articles from the themed issue Proteomics 2014, guest edited by Andrea Urbani, President of the Italian Proteomics Association.
We hope you enjoy this selection!
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