Microfluidic blood plasma separation for medical diagnostics: is it worth it?
This review weights the advantages and limits of miniaturised blood plasma separation and highlights interesting advances in direct biomarker capture.
Flexible sensors for biomedical technology
We provide a selected overview of three types of flexible sensors that have been recently applied to biomedical and healthcare purposes through direct application on the human skin.
A review of digital microfluidics as portable platforms for lab-on a-chip applications
This review evaluates the possibility of developing portable digital microfluidic platforms for lab-on-a-chip applications.
Droplet microfluidics for microbiology: techniques, applications and challenges
Droplet microfluidics has rapidly emerged as one of the key technologies opening up new experimental possibilities in microbiology.
3D-printed fluidic networks as vasculature for engineered tissue
Fabrication of vascular networks within engineered tissue remains one of the greatest challenges facing the fields of biomaterials and tissue engineering.
3D printed microfluidic devices: enablers and barriers
3D printing has the potential to significantly change the field of microfluidics.
The upcoming 3D-printing revolution in microfluidics
A comprehensive exploration of the state-of-the-art and a critical outlook on the advantages, barriers and potential of 3D-printing in microfluidics.
Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics
This review focuses on developments in the field of droplet microfluidics in the context of drug discovery, genomics and transcriptomics.
Distance-based microfluidic quantitative detection methods for point-of-care testing
Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings.
Novel developments in mobile sensing based on the integration of microfluidic devices and smartphones
We review novel mobile sensing applications based on the integration of microfluidic devices and smartphones (MS2).
Microfluidics and microbial engineering
This review highlights the recent development and future opportunities in the interdisciplinary field, integrating microfluidic technology and microbial engineering.
Single cells in confined volumes: microchambers and microdroplets
Microfluidic devices capable of manipulating and guiding small fluid volumes open new methodical approaches in the fields of biology, pharmacy, and medicine.
Soil-on-a-Chip: microfluidic platforms for environmental organismal studies
A review of the most recent developments in so-called “Soil-on-a-Chip” microfluidic technology for environmental organismal studies, including bacteria, nematodes, fungi and plants, as well as inter-organismal interactions.
Fundamentals and applications of inertial microfluidics: a review
We provide a comprehensive review describing the fundamental mechanisms of inertial microfluidics, structure design and applications in biology, medicine and industry.
Active droplet generation in microfluidics
This review presents the state of the art of active microfluidic droplet generation concepts.
A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)
A 3D printed chip for the production of neuron-containing alginate capsules.
A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples
We present a low-cost, disposable, and fully-integrated paperfluidic molecular diagnostic chip for sample-to-result functionality at the point-of-care.
3D printed microfluidic circuitry via multijet-based additive manufacturing
We present a fundamental class of 3D printed microfluidic circuit components and integrated systems constructed using multijet modelling-based approaches.
An integrated paper-based sample-to-answer biosensor for nucleic acid testing at the point of care
An integrated paper-based sample-to-answer biosensor is proposed, which enables simple paper-based nucleic acid extraction, amplification and detection for point-of-care testing.
Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
The beating heart-on-a-chip (i) generates 3D cardiac constructs with well-defined geometries from cell-laden hydrogel prepolymers, (ii) provides uniaxial cyclic mechanical stimulation, (iii) allows efficient delivery of drugs and chemicals.
Handheld real-time PCR device
World's smallest, fully autonomous, handheld real-time PCR was shown in this contribution. The device can quickly process up to four samples at a time with detection capability of a single DNA copy. The fully integrated system includes all required electronics for fluorescence measurement, data viewing (LCD display) and processing, and is ideal for use in small clinics and point-of-care applications.
A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis
Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as a promising biomarker source for cancer diagnosis via a less invasive procedure.
Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays
3D printing enables the rapid and cost-efficient manufacturing of bespoke, complex prototypes. We show that biocompatibility needs to be considered carefully and provide a specific assay to that effect.
LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Sample supply remains the only manual handling step for pathogen detection at the point-of-care.
Digital droplet PCR on disk
An integrated digital droplet PCR system is presented that enables droplet generation, PCR amplification, and readout within a single reaction chamber on a centrifugal microfluidic LabDisk.
About this collection
This web collection features the top 25 most downloaded articles published in Lab on a Chip in 2016. Congratulations to all of the authors whose articles have been featured!