Mission impossible to mission control
This Lab on a Chip themed issue – an issue dedicated to the work of Emerging Investigators – sees miniaturisation bringing unprecedented control to chemistry, physics, biology and bioengineering.
Emerging investigators contributors 2012
Contributors to the 2012 Emerging Investigators issue of Lab on a Chip.
A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils
Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process.
Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin
We developed a simple and novel one-step approach to produce G/O/W emulsions with high gas volume fractions in a capillary microfluidic device. The thickness of the oil layer can be controlled easily by tuning the flow rates. We successfully used the G/O/W emulsions to prepared hollow microspheres with thin polymer shells.
Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells
We developed a microbioreactor providing time sequences of space-resolved gradients of multiple molecular factors in 3D cell culture settings, along with a versatile, high-throughput operation and imaging compatibility.
Microfluidic filtration system to isolate extracellular vesicles from blood
We introduce a microfluidic filtration approach to purify extracellular vesicles directly from whole blood rapidly and without using a centrifuge.
Semi-autonomous liquid handling via on-chip pneumatic digital logic
Digital logic circuits implemented by microfluidic valves and channels are used to control liquid metering, mixing, incubation, and wash procedures with minimal external controls.
Automated generation of libraries of nL droplets
We demonstrate an integrated system for rapid and automated generation of multiple, chemically distinct populations of ∼103–104 sub-nanoliter droplets.
Concentration gradient generation of multiple chemicals using spatially controlled
self-assembly of particles in microchannels
We present a robust microfluidic platform for the stable generation of multiple chemical gradients simultaneously using in situ self-assembly of particles in microchannels.
A study of the production and reversible stability of EGaIn liquid metal microspheres using flow focusing
Production of recoverable liquid metal (EGaIn) microspheres through microfluidic flow focusing is demonstrated and compared to a model water-in-oil system.
Microfluidic photoelectrocatalytic reactors for water
purification with an integrated visible-light source
A photoelectrocatalytic microreactor inhibits electron/hole recombination, selectively controls the reaction pathways and brings out the synergistic effect of photocatalysis and electrocatalysis.
microscope for in situ monitoring of cells
A mini-microscope was developed for in situ monitoring of cells by modifying off-the-shelf components of a commercial webcam.
Double spiral microchannel for label-free tumor cell separation and enrichment
A double spiral microfluidic platform allows for passive, label-free tumor cell enrichment from whole blood with improved throughput and efficiency.
Integrated electrofluidic circuits: pressure sensing with analog and digital operation functionalities for microfluidics
We report the concept of electrofluidic circuits – electrical circuits that are constructed using ionic liquid-filled fluidic channels for pressure sensing with analog and digital operation functionalities.
spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance
We demonstrate a nanohole-based surface plasmon resonance imaging spectroscopy instrument capable of simultaneously extracting receptor–ligand binding kinetics and affinities from 50 parallel microfluidic channels in real time.
Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip
A sensor that was specific for RS-melagatran was fabricated, and the presence of 10 000-fold amounts of SR-melagatran did not interfere with the detection.
Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level
An agarose droplet-based microfluidic single-cell ePCR method has been developed for highly sensitive, specific and quantitative detection of single E. coli O157:H7 cells in the high background of 100 000 excess normal K12 cells.
Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device
Water disinfection byproducts (DBPs) are a class of chemicals that are produced when chemical disinfectants react with organic materials in untreated water.
A rotary microsystem for simple, rapid and automatic RNA purification
In this paper, we demonstrate a novel rotary microsystem capable of highly simple, rapid and automatic influenza viral RNA purification.
Fusion and sorting of two parallel trains of droplets using a railroad-like channel network and guiding tracks
We propose a robust droplet fusion and sorting method for two parallel trains of droplets that is relatively insensitive to frequency and phase mismatch.
drug efflux assay in bacteria by using a directly accessible femtoliter droplet array
Drug efflux activity in single bacterium was assessed in directly accessible femtoliter-droplet, and efflux-active single cell was collected and the harboured plasmid was analyzed.
An automated microfluidic device for assessment of mammalian cell genetic stability
A high-throughput integrated microfluidic device is developed for rapid measurement of gene expression in individual cells for genetic stability assessment.
Microfabricated ratchet structure integrated concentrator arrays for synthetic bacterial cell-to-cell communication assays
This work reports a microfluidic concentrator array device confining bacterial cells in a controllable fashion for synthetic cell-to-cell communication assays.
Optical microplates for high-throughput screening of photosynthesis in
Optical microplates provide a temporal light stimulus in each well of a standard 96-well plate, enabling high-throughput studies of light-driven bioprocesses, such as photosynthesis.
“Overpass” at the junction of a crossed microchannel: An enabler for 3D microfluidic chips
We report the design and fabrication of three-dimensional “overpass” microstructures at the junction of crossed microchannels for 3D microchips.
About this collection
Lab on a Chip is committed to supporting early career scientists, and it is because of this that we are both proud and very pleased to introduce the 2012 edition of our emerging investigators issue, which celebrates the best and brightest amongst early career miniaturisation scientists around the world. This issue was guest edited by Aaron R Wheeler and Amy E Herr who worked hard to create this issue and ensure that its content was of the highest quality. Please read the articles below to see how our emerging investigators are contributing to the world of miniaturisation.