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Themed collection 2012 Lab on a Chip Emerging Investigators

25 items
Editorial

Mission impossible to mission control

This Lab on a Chip themed issue – an issue dedicated to the work of Emerging Investigators – sees miniaturisation bringing unprecedented control to chemistry, physics, biology and bioengineering.

Graphical abstract: Mission impossible to mission control
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Profile

Emerging investigators contributors 2012

Contributors to the 2012 Emerging Investigators issue of Lab on a Chip.

Graphical abstract: Emerging investigators contributors 2012
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Communication

A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils

Here, we present a novel method for establishing in vivo-like inflammatory models in a microfluidic device and quantitatively measuring the three-dimensional transmigration of neutrophils during the inflammatory process.

Graphical abstract: A versatile assay for monitoring in vivo-like transendothelial migration of neutrophils
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Communication

Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells

We developed a simple and novel one-step approach to produce G/O/W emulsions with high gas volume fractions in a capillary microfluidic device. The thickness of the oil layer can be controlled easily by tuning the flow rates. We successfully used the G/O/W emulsions to prepared hollow microspheres with thin polymer shells.

Graphical abstract: Controllable microfluidic production of gas-in-oil-in-water emulsions for hollow microspheres with thin polymer shells
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells

We developed a microbioreactor providing time sequences of space-resolved gradients of multiple molecular factors in 3D cell culture settings, along with a versatile, high-throughput operation and imaging compatibility.

Graphical abstract: Microfluidic bioreactor for dynamic regulation of early mesodermal commitment in human pluripotent stem cells
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Microfluidic filtration system to isolate extracellular vesicles from blood

We introduce a microfluidic filtration approach to purify extracellular vesicles directly from whole blood rapidly and without using a centrifuge.

Graphical abstract: Microfluidic filtration system to isolate extracellular vesicles from blood
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Semi-autonomous liquid handling via on-chip pneumatic digital logic

Digital logic circuits implemented by microfluidic valves and channels are used to control liquid metering, mixing, incubation, and wash procedures with minimal external controls.

Graphical abstract: Semi-autonomous liquid handling via on-chip pneumatic digital logic
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Automated generation of libraries of nL droplets

We demonstrate an integrated system for rapid and automated generation of multiple, chemically distinct populations of ∼103–104 sub-nanoliter droplets.

Graphical abstract: Automated generation of libraries of nL droplets
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Concentration gradient generation of multiple chemicals using spatially controlled self-assembly of particles in microchannels

We present a robust microfluidic platform for the stable generation of multiple chemical gradients simultaneously using in situ self-assembly of particles in microchannels.

Graphical abstract: Concentration gradient generation of multiple chemicals using spatially controlled self-assembly of particles in microchannels
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

A study of the production and reversible stability of EGaIn liquid metal microspheres using flow focusing

Production of recoverable liquid metal (EGaIn) microspheres through microfluidic flow focusing is demonstrated and compared to a model water-in-oil system.

Graphical abstract: A study of the production and reversible stability of EGaIn liquid metal microspheres using flow focusing
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Microfluidic photoelectrocatalytic reactors for water purification with an integrated visible-light source

A photoelectrocatalytic microreactor inhibits electron/hole recombination, selectively controls the reaction pathways and brings out the synergistic effect of photocatalysis and electrocatalysis.

Graphical abstract: Microfluidic photoelectrocatalytic reactors for water purification with an integrated visible-light source
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

A mini-microscope for in situ monitoring of cells

A mini-microscope was developed for in situ monitoring of cells by modifying off-the-shelf components of a commercial webcam.

Graphical abstract: A mini-microscope for in situ monitoring of cells
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Double spiral microchannel for label-free tumor cell separation and enrichment

A double spiral microfluidic platform allows for passive, label-free tumor cell enrichment from whole blood with improved throughput and efficiency.

Graphical abstract: Double spiral microchannel for label-free tumor cell separation and enrichment
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Integrated electrofluidic circuits: pressure sensing with analog and digital operation functionalities for microfluidics

We report the concept of electrofluidic circuits – electrical circuits that are constructed using ionic liquid-filled fluidic channels for pressure sensing with analog and digital operation functionalities.

Graphical abstract: Integrated electrofluidic circuits: pressure sensing with analog and digital operation functionalities for microfluidics
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Real-time full-spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance

We demonstrate a nanohole-based surface plasmon resonance imaging spectroscopy instrument capable of simultaneously extracting receptor–ligand binding kinetics and affinities from 50 parallel microfluidic channels in real time.

Graphical abstract: Real-time full-spectral imaging and affinity measurements from 50 microfluidic channels using nanohole surface plasmon resonance
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip

A sensor that was specific for RS-melagatran was fabricated, and the presence of 10 000-fold amounts of SR-melagatran did not interfere with the detection.

Graphical abstract: Enantioselective analysis of melagatran via an LSPR biosensor integrated with a microfluidic chip
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level

An agarose droplet-based microfluidic single-cell ePCR method has been developed for highly sensitive, specific and quantitative detection of single E. coli O157:H7 cells in the high background of 100 000 excess normal K12 cells.

Graphical abstract: Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic emulsion PCR at the single-cell level
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device

Water disinfection byproducts (DBPs) are a class of chemicals that are produced when chemical disinfectants react with organic materials in untreated water.

Graphical abstract: Cytotoxicity analysis of water disinfection byproducts with a micro-pillar microfluidic device
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

A rotary microsystem for simple, rapid and automatic RNA purification

In this paper, we demonstrate a novel rotary microsystem capable of highly simple, rapid and automatic influenza viral RNA purification.

Graphical abstract: A rotary microsystem for simple, rapid and automatic RNA purification
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Fusion and sorting of two parallel trains of droplets using a railroad-like channel network and guiding tracks

We propose a robust droplet fusion and sorting method for two parallel trains of droplets that is relatively insensitive to frequency and phase mismatch.

Graphical abstract: Fusion and sorting of two parallel trains of droplets using a railroad-like channel network and guiding tracks
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array

Drug efflux activity in single bacterium was assessed in directly accessible femtoliter-droplet, and efflux-active single cell was collected and the harboured plasmid was analyzed.

Graphical abstract: A single-cell drug efflux assay in bacteria by using a directly accessible femtoliter droplet array
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

An automated microfluidic device for assessment of mammalian cell genetic stability

A high-throughput integrated microfluidic device is developed for rapid measurement of gene expression in individual cells for genetic stability assessment.

Graphical abstract: An automated microfluidic device for assessment of mammalian cell genetic stability
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Paper

Microfabricated ratchet structure integrated concentrator arrays for synthetic bacterial cell-to-cell communication assays

This work reports a microfluidic concentrator array device confining bacterial cells in a controllable fashion for synthetic cell-to-cell communication assays.

Graphical abstract: Microfabricated ratchet structure integrated concentrator arrays for synthetic bacterial cell-to-cell communication assays
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Technical Innovation

Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae

Optical microplates provide a temporal light stimulus in each well of a standard 96-well plate, enabling high-throughput studies of light-driven bioprocesses, such as photosynthesis.

Graphical abstract: Optical microplates for high-throughput screening of photosynthesis in lipid-producing algae
From the themed collection: 2012 Lab on a Chip Emerging Investigators
Technical Innovation

“Overpass” at the junction of a crossed microchannel: An enabler for 3D microfluidic chips

We report the design and fabrication of three-dimensional “overpass” microstructures at the junction of crossed microchannels for 3D microchips.

Graphical abstract: “Overpass” at the junction of a crossed microchannel: An enabler for 3D microfluidic chips
From the themed collection: 2012 Lab on a Chip Emerging Investigators
25 items

About this collection

Lab on a Chip is committed to supporting early career scientists, and it is because of this that we are both proud and very pleased to introduce the 2012 edition of our emerging investigators issue, which celebrates the best and brightest amongst early career miniaturisation scientists around the world. This issue was guest edited by Aaron R Wheeler and Amy E Herr who worked hard to create this issue and ensure that its content was of the highest quality. Please read the articles below to see how our emerging investigators are contributing to the world of miniaturisation.

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