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Themed collection Organs on a Chip 2013

23 items
Editorial

Organs on Chips 2013

Professors Beebe, Ingber and den Toonder introduce the Lab on a Chip and Integrative Biology cross journal themed collection on ‘Organs-on-a-Chip’.

Graphical abstract: Organs on Chips 2013
From the themed collection: Organs on a Chip 2013
Frontier

Building risk-on-a-chip models to improve breast cancer risk assessment and prevention

Modifiable (green) and nonmodifiable (red) factors cooperatively define breast cancer risk and need to be studied into biosensors-equipped physiologically relevant ‘risk-on-a-chip’ models for cancer prevention studies.

Graphical abstract: Building risk-on-a-chip models to improve breast cancer risk assessment and prevention
From the themed collection: Organs on a Chip 2013
Focus

Workshop meeting report Organs-on-Chips: human disease models

“Organs-on-Chips”: unprecedented opportunities to develop human organ and disease models, envisioned to revolutionize cell culture, cell biology and drug development.

Graphical abstract: Workshop meeting report Organs-on-Chips: human disease models
From the themed collection: Organs on a Chip 2013
Review Article

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment

This critical review examines the advancement of microfluidic technologies developed to tackle the outstanding challenges related to the tumor microenvironment.

Graphical abstract: Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment
From the themed collection: Organs on a Chip 2013
Open Access Critical Review

Scaling and systems biology for integrating multiple organs-on-a-chip

The implementation of milliHuman (mHu) or microHuman (μHu) coupled systems of human organ constructs or organs-on-chips must address the relative scaling of each organ, using either allometric or functional guidelines.

Graphical abstract: Scaling and systems biology for integrating multiple organs-on-a-chip
From the themed collection: Organs on a Chip 2013
Open Access Critical Review

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine

The needs of regenerative medicine research and the tools microfluidics offers to meet these needs.

Graphical abstract: Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine
From the themed collection: Organs on a Chip 2013
Critical Review

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

In this review, we focus on advanced microfluidic microscale liver equivalents, appraising them against the level of architectural and, consequently, functional identity with their human counterpart in vivo.

Graphical abstract: Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput
From the themed collection: Organs on a Chip 2013
Critical Review

The future of the patient-specific Body-on-a-chip

As significant advancements in technology focused on Organ-on-a-chip continue, it is feasible to consider the future of Body-on-a-chip technology.

Graphical abstract: The future of the patient-specific Body-on-a-chip
From the themed collection: Organs on a Chip 2013
Communication

Disease-on-a-chip: mimicry of tumor growth in mammary ducts

Tumors (red) within a circular luminal breast epithelium mimicking cancer growth in a mammary duct. Inset: orthogonal view of a tumor.

Graphical abstract: Disease-on-a-chip: mimicry of tumor growth in mammary ducts
From the themed collection: Organs on a Chip 2013
Paper

Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury

The use of nanoparticles in medical applications is highly anticipated, and at the same time little is known about how these nanoparticles affect human tissues.

Graphical abstract: Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
From the themed collection: Organs on a Chip 2013
Paper

On being the right size: scaling effects in designing a human-on-a-chip

We have investigated approaches to appropriately scale the components of a ‘human-on-a-chip’ to design a generalized model for drug efficacy and toxicity screening.

Graphical abstract: On being the right size: scaling effects in designing a human-on-a-chip
From the themed collection: Organs on a Chip 2013
Paper

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

Human intestinal epithelial Caco-2 cells cultured in a microengineered Gut-on-a-Chip are reprogrammed to spontaneously undergo villus morphogenesis and cytodifferentiation that closely mimics human small intestinal villi.

Graphical abstract: Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
From the themed collection: Organs on a Chip 2013
Paper

A multiphase fluidic platform for studying ventilator-induced injury of the pulmonary epithelial barrier

Mechanical ventilation has been a critical part of basic life support for many years, with almost one-third of all patients in the intensive care unit requiring the aid.

Graphical abstract: A multiphase fluidic platform for studying ventilator-induced injury of the pulmonary epithelial barrier
From the themed collection: Organs on a Chip 2013
Paper

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

Human kidney proximal tubule-on-a-chip lined by living cells exposed to fluidic flow mimics proximal tubular morphology, function and drug toxicity responses.

Graphical abstract: Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment
From the themed collection: Organs on a Chip 2013
Paper

Microfluidic titer plate for stratified 3D cell culture

A microfluidic titer plate for 3D cell culture is reported. The phaseguide-stratified setup enables passive perfusion and co-culture in high-throughput.

Graphical abstract: Microfluidic titer plate for stratified 3D cell culture
From the themed collection: Organs on a Chip 2013
Paper

Microfluidic heart on a chip for higher throughput pharmacological studies

Heart on a chip incorporated into fluidic microdevices amenable to higher throughput in vitro studies of structural and contractile properties.

Graphical abstract: Microfluidic heart on a chip for higher throughput pharmacological studies
From the themed collection: Organs on a Chip 2013
Paper

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

We describe a microfluidic, three-dimensional model of a blood vessel. We analyze the structural organization and the three-dimensional interaction between human primary endothelial cells and human pluripotent stem cell-derived pericytes.

Graphical abstract: Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device
From the themed collection: Organs on a Chip 2013
Open Access Paper

Hydrogel-coated microfluidic channels for cardiomyocyte culture

A method to coat microfluidic channels with a hydrogel to promote cell adhesion for organ-on-a-chip applications is presented.

Graphical abstract: Hydrogel-coated microfluidic channels for cardiomyocyte culture
From the themed collection: Organs on a Chip 2013
Paper

Integrating biological vasculature into a multi-organ-chip microsystem

A chip-based platform mimicking the transport function of the cardiovascular system, a crucial part of future human-on-a-chip culture, was developed.

Graphical abstract: Integrating biological vasculature into a multi-organ-chip microsystem
From the themed collection: Organs on a Chip 2013
Paper

A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture

For the first time, a co-culture of human liver and skin equivalents on dynamic micro-chips has been performed.

Graphical abstract: A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
From the themed collection: Organs on a Chip 2013
Paper

Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

In vitro skin model, ex vivo skin and hair follicular units were cultured in a dynamically perfused chip-based bioreactor.

Graphical abstract: Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion
From the themed collection: Organs on a Chip 2013
Paper

Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue

A liver-lobule-mimetic reconstruction for centimeter-scale liver tissue of heterogeneous hepatic and endothelial cells is demonstrated. This could be promisingly applied to the fields of tissue engineering, drug development and liver physiology studies.

Graphical abstract: Liver-cell patterning Lab Chip: mimicking the morphology of liver lobule tissue
From the themed collection: Organs on a Chip 2013
Paper

Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects

The osmotic pump can generate the main driving power of the system in the spheroid-based three-dimensional liver-on-a-chip.

Graphical abstract: Spheroid-based three-dimensional liver-on-a-chip to investigate hepatocyte–hepatic stellate cell interactions and flow effects
From the themed collection: Organs on a Chip 2013
23 items

About this collection

A cross journal themed collection across Lab on a Chip and Integrative Biology, guest edited by Professors David J. Beebe, Donald E. Ingber and Jaap den Toonder focussing on "Organs-on-a-Chip".

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