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Issue 1, 2014
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Disease-on-a-chip: mimicry of tumor growth in mammary ducts

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Abstract

We present a disease-on-a-chip model in which cancer grows within phenotypically normal breast luminal epithelium on semicircular acrylic support mimicking portions of mammary ducts. The cells from tumor nodules developing within these hemichannels are morphologically distinct from their counterparts cultured on flat surfaces. Moreover, tumor nodules cocultured with the luminal epithelium in hemichannels display a different anticancer drug sensitivity compared to nodules cocultured with the luminal epithelium on a flat surface and to monocultures of tumor nodules. The mimicry of tumor development within the epithelial environment of mammary ducts provides a framework for the design and test of anticancer therapies.

Graphical abstract: Disease-on-a-chip: mimicry of tumor growth in mammary ducts

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Publication details

The article was received on 10 Jul 2013, accepted on 28 Oct 2013 and first published on 29 Oct 2013


Article type: Communication
DOI: 10.1039/C3LC50819F
Lab Chip, 2014,14, 172-177

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    Disease-on-a-chip: mimicry of tumor growth in mammary ducts

    P. Vidi, T. Maleki, M. Ochoa, L. Wang, S. M. Clark, J. F. Leary and S. A. Lelièvre, Lab Chip, 2014, 14, 172
    DOI: 10.1039/C3LC50819F

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