Themed collection Biomaterials Science Most Popular 2022

In this paper, the assembly process and the material properties of MPNs are discussed, and the application scope and prospect of MPNs are clarified. This paper provides new ideas for the construction of nanoplatforms for therapeutics and diagnostics.

Porous organic polymers have received considerable attention in recent years because of their applicability as biomaterials.

Aggregation-induced emission (AIE) photosensitizers (PSs) are promising anti-tumor materials in photodynamic therapy.

Multifunctional wound dressings or smart dressings with pro-angiogenic function, antibacterial properties, anti-inflammatory/antioxidant activity and tissue adhesion for chronic wound repair.

Non-viral delivery technologies for efficient in vivo Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR/Cas9) gene editing.

The tissue engineering triad of biomaterials, cells and therapeutics as it applies to the formulation of biomimetic bioinks for cartilage repair. These bioinks can be functionalised with cells or cellular therapeutics to promote cartilage repair.

Coating and targeting strategies improve superparamagnetic iron oxide nanoparticles-induced hyperthermia, while omics can unveil molecular effects.

Delivery of the CRISPR/Cas9 system can be realized by utilizing different biomolecular formats, each featuring individual characteristics, advantages and challenges.

Intestinal epithelium models based on biomimetic scaffolds with an ECM micro-architecture and intestinal macro-elasticity are close to their counterpart intestinal tissues, serving as powerful in vitro tools to assess the immunobiotics–host interactions.

A HTP 3D bioprinted cell migration platform that has broad applications across quantitative cell and cancer biology as well as drug screening.

Colchicine-Soluplus® was loaded into dissolving microarray patches for a new minimally-invasive alternative strategy for management of acute gout.

A novel PBO hydrogel based on PVA, borax and oligomeric procyanidin was designed with adhesive, self-healing, antimicrobial, and on-demand removable capabilities for rapid hemostasis.

The schematic illustration of the effect of the brain-targeted engineered exosome-mediated BDNF on oligodendrocyte differentiation in vitro and remyelination in vivo through intranasal administration.

We have demonstrated the ability of mRNA-carrying lipid nanoparticles to activate NLRP3 inflammasomes is highly dependent on lipid composition, affecting the endo/lysosomal rupture or calcium influx/mitochondrial ROS production by the nanoparticle.

Dynamic hydrogels can allow cells to form complex multicellular aggregates. Herein, we show that the dynamics of the hydrogel environment can directly influence the speed and size of cellular aggregates formed by using a modularly tunable supramolecular hydrogel.

A new aza-BODIPY-based NIR-II luminogen enables efficient phototheranostics.

Not all ionizable lipids are the same – choosing the right one is critical to the success of lipid nanoparticles for different applications.

A novel curcumin doped zeolitic imidazolate framework nanoplatform was synthesized by a metal coordination strategy, which could effectively improve the application of curcumin in tumor therapy and improve anti-tumor immunity.

Transparent, cytocompatible and high resolution 3D-DLP-printing offers new opportunities in cell culture and organs-on-a-chip.

Accurately recognizing CTCs in peripheral blood based on the TiO₂@Ag–R6G–rBSA–FA SERS bioprobe is carefully verified by in situ immunofluorescence staining experiments, which directly supports the CTC detection accuracy of the SERS strategy.