Themed collection Analytical Methods HOT Articles 2021
Recent advances in selective formaldehyde detection in biological and environmental samples by fluorometric and colorimetric chemodosimeters
In this minireview, we have comprehensively discussed recent advances in the design principles and sensing mechanisms of developed probes and their biological/environmental applications in selective formaldehyde detection.
The emerging role of 3D-printing in ion mobility spectrometry and mass spectrometry
3D-printing enables the rapid prototyping of ion mobility (IMS) and mass spectrometry (MS) gadgets. The RepRap components are suitable for building cost-efficient robots and MS imaging systems. In this review, we present current trends.
Beyond principal components: a critical comparison of factor analysis methods for subspace modelling in chemistry
Principal components analysis (PCA) is widely used in analytical chemistry, but is only one type of broader range of factor analysis tools that are described in this article.
Taylor dispersion analysis in fused silica capillaries: a tutorial review
Observations of band broadening under well-controlled laminar flow enable absolute, calibration-free determinations of diffusion coefficient.
Molecular diagnostics in the era of COVID-19
As the COVID-19 pandemic continues to escalate globally and acquires new mutations, accurate diagnostic technologies continue to play a vital role in controlling and understanding the epidemiology of this disease.
Analytical applications of single particle inductively coupled plasma mass spectrometry: a comprehensive and critical review
Real-world applications of single-particle ICP-MS are comprehensively and critically reviewed.
Regulating metal–organic frameworks as stationary phases and absorbents for analytical separations
Metal–organic frameworks (MOFs) are highly ordered framework systems composed of metal centers and organic linkers formed through coordination bonds.
Open port sampling interface mass spectrometry of wipe-based explosives, oxidizers, and narcotics for trace contraband detection
The solid–liquid extraction capabilities of open port sampling interface mass spectrometry enabled rapid and sensitive detection of military-grade explosives, homemade explosive oxidizers, and narcotics, critical to screening applications.
A dual-channel Hill-type small-molecule pH probe
A Hill-type FRET-based ratiometric pH probe (PHHF) was designed and synthesized for sensitively detecting minor pH variations of lysosomes.
Analysis of antioxidants in Chrysanthemum indici flos by online gradient extraction and HPLC-FRAP
Analysis of antioxidants in Chrysanthemum indici flos by online gradient extraction and HPLC-FRAP.
Simple mercury determination using an enclosed quartz cell with cold vapour-atomic absorption spectrometry
A simple method for determining total inorganic mercury (Hg) in solution using an enclosed quartz cell applying cold vapour-atomic absorption spectrometry (CV-AAS) can reduce sample volume, reductant, and cost compared with those of official methods.
Sensitive osteosarcoma diagnosis through five-base telomerase product-triggered CRISPR-Cas12a enhanced rolling circle amplification
CRISPR-Cas12a assisted rolling circle amplification for sensitive osteosarcoma diagnosis.
Application of new N- and S-doped amorphous carbon in D-μSPE and its combination with deep eutectic solvent-based DLLME for the extraction of some mycotoxins from soymilk
A new amorphous carbon-based dispersive micro solid-phase extraction method was developed for the extraction and preconcentration of several mycotoxins from soymilk samples.
Affiblot: a dot blot-based screening device for selection of reliable antibodies
A report on a palm-sized dot blot-based device that allows simultaneous semi-quantitative comparison of up to five antibodies from different suppliers regarding their affinity/avidity, cross-reactivity, and batch-to-batch reliability.
A novel approach to detect barium in gunshot residue using a handheld device: a forensic application
The aim of the study is to develop a handheld device based on the colorimetric detection of Ba2+ metal in gunshot residue using gold nanoparticles capped with sodium malonate with great sensitivity and selectivity.
Thiol-mediated etching of gold nanorods as a neoteric strategy for room-temperature and multicolor detection of nitrite and nitrate
Thiourea as a sulfur-containing compound accelerates the etching rate of gold nanorods (AuNRs) leading to a wide color change from brown to light brown, green, blue, purple, pink, and colorless.
Smartphone-based colorimetric detection system for portable health tracking
The use of colorimetric sensors is encouraged by their simple operation, but limited by the lack of standardization. This article reports on a smartphone application to precisely readout urine strips via color mapping and RGB-to-HSV transposition.
Detection of Glyphosate with a Copper(II)-Pyrocatechol Violet Based GlyPKit
A Full Spectral Analysis Method for the Gamma Spectrum: Weighted Library Least Squares
Detection of hydrogen peroxide and glucose with a novel fluorescent probe by the enzymatic reaction of amino functionalized MOF nanosheets
The mechanism for detecting H2O2 and glucose in the system of the NH2-MIL-53(Al)-HRP enzymatic reaction.
A novel fluorescent probe based on a triphenylamine derivative for the detection of HSO3− with high sensitivity and selectivity
The probe has excellent sensitivity, fast response and low limit of detection to HSO3−. The mechanism was verified by density functional theory (DFT) and time-dependent DFT. The sensor has been successfully imaged in RAW264.7 cells.
Simulation and machine learning modelling based comparative study of InAlGaN and AlGaN high electron mobility transistors for the detection of HER-2
For the first time, a InAlGaN based HEMT has been used for biosensing applications. Also, machine learning techniques are introduced in the modelling of the physics of a semiconductor device.
Quantitative and specific detection of viable pathogens on a portable microfluidic chip system by combining improved propidium monoazide (PMAxx) and loop-mediated isothermal amplification (LAMP)
Improved propidium monoazide (PMAxx) and loop-mediated isothermal amplification (LAMP) were used to distinguish between viable and dead C. albicans. A portable microfluidic chip system was developed to detect multiple viable pathogens in parallel.
Lysosome targeting, Cr(VI) and L-AA sensing, and cell imaging based on N-doped blue-fluorescence carbon dots
N-doped blue-fluorescence carbon dots (N-CDs) were fabricated via a one-pot hydrothermal method using folic acid and p-phenylenediamine.
The evaluation of the chemical quality and UV overall components dissolution consistency of Flos Chrysanthemi Indici preparation
Integrating capillary electrophoresis fingerprints and UV overall components dissolution consistency to give the overall quality control of Flos Chrysanthemi Indici preparation.
Rapid quantitative analysis of trace elements in plutonium alloys using a handheld laser-induced breakdown spectroscopy (LIBS) device coupled with chemometrics and machine learning
We present the first reported quantification of trace elements in plutonium via a portable laser-induced breakdown spectroscopy (LIBS) device and demonstrate the use of chemometric analysis to enhance the handheld device's sensitivity and precision.
An ultrasensitive homogeneous electrochemical biosensor based on CRISPR-Cas12a
A simple and immobilization-free homogeneous electrochemical biosensor for the detection of human papillomavirus (HPV-16) has been fabricated by combining with methylene blue (MB)-labeled probes toward the negatively-charged indium tin oxide (ITO) electrode.
Thermo-sensitivity of hybrid nanogels for specific endogenous hydrogen sulfide detection and efficient flash chill treatment
Thermo-responsive nanogels, poly(NIPAM–AAM) were prepared by a facile method of free radical one-pot precipitation based on monomeric N-isopropylacrylamide (NIPAM).
An integrating strategy for serum metabolomics and microarray analysis to expand the understanding of diet-induced obesity
Obesity is a key component of metabolic syndrome and is precipitated by complex interactions between multiple environmental and genetic factors.
Detection of organic and inorganic gunshot residues from hands using complexing agents and LC-MS/MS
LC-MS/MS and guest-host chemistry is a viable approach for the dual detection of organic and inorganic gunshot residue.
Ultrasensitive immunochromatographic strip for the detection of cyhalothrin in foods
A quantitative immunochromatographic strip assay has been developed for rapid screening of lambda-cyhalothrin in foods.
Three asymmetric BODIPY derivatives as fluorescent probes for highly selective and sensitive detection of cysteine in living cells
Three new asymmetric BODIPY-based fluorescent probes were designed and synthesized for highly selective and sensitive detection of cysteine. These probes were able to image exogenous and endogenous Cys through green or red channels in living cells.
Rapid and sensitive detection of Staphylococcus aureus and Klebsiella pneumonia based on bacitracin-modified Fe3O4@PDA magnetic beads combined with matrix-assisted laser desorption ionization-time of flight mass spectrometry
Bacitracin was immobilized on the surface of Fe3O4@PDA magnetic nanoparticles for the rapid enrichment and sensitive detection of Staphylococcus aureus (G+) and Klebsiella pneumoniae (G−) in biological samples combined with MALDI-TOF MS.
A new method for cartap detection with high sensitivity and selectivity based on the inner filter effect between GSH-Cu NCs and Au NPs
A schematic diagram of sensing cartap using the IFE between GSH-Cu NCs and Au NPs.
A multi-residue chiral liquid chromatography coupled with tandem mass spectrometry method for analysis of antifungal agents and their metabolites in aqueous environmental matrices
A new analytical method for combined separation of chiral and chiral antifungal agents in the environment has been developed.
Nanobiosensing based on optically selected antibodies and superparamagnetic labels for rapid and highly sensitive quantification of polyvalent hepatitis B surface antigen
Magnetic LF assay for rapid quantification of HBsAg in serum.
Fluorometric discrimination of tyrosine isomers based on the inner filter effect of chiral Au nanoparticles on MoS2 quantum dots
A sensitive fluorescent chiral sensor is developed based on the inner filter effect of chiral Au nanoparticles on MoS2 quantum dots, which can be used for the discrimination of tyrosine isomers.
The development of an endoplasmic reticulum-targeting fluorescent probe for the imaging of 1,4-dithiothreitol (DTT) in living cells
An effective turn-on ER-targeting fluorescent probe ER-DTT was designed to image DTT of endoplasmic reticulum for the first time.
Highly selective and rapid detection of silver ions by using a “turn on” non-fluorescent cysteine stabilized gold nanocluster probe
Highly selective and rapid detection of silver ions by using a “turn on” non-fluorescent gold nanocluster probe.
A substantial increase of analytical throughput in capillary electrophoresis throughput by separation-interrupted sequential injections
We proposed an idea of separation-interrupted sequential injections (Sisi) to substantially increase the throughput of CE together with theory and experimental demonstration. The separation time of Sisi-CE-C4D/C4D is only 21% of that of normal CE.
A novel ratiometric fluorescent probe from a hemicyanine derivative for detecting NAD(P)H in a cell microenvironment
In this paper, a ratiometric fluorescent probe for NAD(P)H derived from coumarin and hemicyanine was synthesized. The ratiometric fluorescent probe provided an important theoretical basis for sensing NAD(P)H.
Simultaneous immunodetection of ionophore antibiotics, salinomycin and narasin, in poultry products and milk
Immunoassay of ionophore antibiotics, salinomycin and narasin, was first developed for milk analysis. Good recovery was promoted by the absence of Na+–K+ ions in tested samples.
Simple chemical detection based on a surface-modified electroosmotic pump via interval immobilization
Environmental water quality monitoring plays an important role in human health risk assessments for pharmaceuticals in water and pollutant source control.
Developing in vitro models to assess fish gill excretion of emerging contaminants
In vitro fish gill model to study the branchial efflux of emerging contaminants at ever lower concentrations in freshwater.
Homo-FRET enhanced ratiometric fluorescence strategy for exonuclease III activity detection
A homo-FRET enhanced ratiometric fluorescence method has been developed successfully for the detection of Exo III activity.
A novel all-3D-printed thread-based microfluidic device with an embedded electrochemical detector: first application in environmental analysis of nitrite
A fully 3D-printed microfluidic thread-based device containing an embedded electrochemical detector is first reported. A green method based on microflow injection analysis for sensing of nitrite ions in environmental samples is also first presented.
Theoretical and experimental verification of imaging resolution factors in scanning electrochemical microscopy
The mathematical expression for the real-time current of the SECM tip and the imaging resolution has been derived, which revealed the effects of tip electrode size and tip–substrate distance on imaging resolution.
The extraction of phenolic acids and polysaccharides from Lilium lancifolium Thunb. using a deep eutectic solvent
This study provided a new application of deep eutectic solvents (DESs) in the simultaneous extraction of phenolic acids and polysaccharides from the bulbs of Lilium lancifolium Thunb.
Preparative separation of seven polyphenols from Perillae Folium via pH-zone-refining counter-current chromatography combined with high-speed counter-current chromatography
A separation method using pH-ZRCCC combined with HSCCC was proposed to separate the crude sample of Perillae Folium with different constituents and polarity, and three phenolic acids and four flavonoid glycosides were isolated successfully.
Construction of fluorescent rotors with multiple intramolecular rotation sites for visualization of cellular viscous compartments with elevated fidelity
The chemical structure and response to viscosity of SP-6, TAPI-6 and TAPI-16.
Carbon dots derived from Fusobacterium nucleatum for intracellular determination of Fe3+ and bioimaging both in vitro and in vivo
Fusobacterium nucleatum has been employed for the first time to synthesize fluorescent carbon dots which could be applied for the determination of Fe3+ ions in living cells and bioimaging in vitro and in vivo with excellent biocompatibility.
Rapid analysis of anionic and cationic surfactants in water by paper spray mass spectrometry
We present the development of PS-MS into an analytical tool for the study of surfactants in water samples. The method has a short analysis time, low solvent consumption, no need for sample pretreatment and simultaneous multi-surfactant detection.
Surfactant-functionalised magnetic ferum oxide coupled with high performance liquid chromatography for the extraction of phenol
Figure shows the schematic extraction procedure of the developed magnetic adsorbent for simple and fast extraction of phenol from environmental water samples.
Analysis of pyrethroids in cereals by HPLC with a deep eutectic solvent-based dispersive liquid–liquid microextraction with solidification of floating organic droplets
A hydrophobic deep eutectic solvent is used as a green extractant.
A molecularly imprinted polymer-based potentiometric sensor based on covalent recognition for the determination of dopamine
For the first time, an MIP potentiometric sensor based covalent recognition for the determination of protonated dopamine is described.
A strategy based on isocratic and linear-gradient high-speed counter-current chromatography for the comprehensive separation of platycosides from Platycodi radix
Eight platycosides and three tautomers of acetylated platycosides were isolated from Platycodi radix by an efficient method combined MCI resin column chromatography with isocratic and linear-gradient high-speed counter-current chromatography.
A spot test for direct quantification of acid green 16 adsorbed on a molecularly imprinted polymer through diffuse reflectance measurements
This work describes a novel technique for the direct quantification of Acid Green 16 (AG16) adsorbed on a molecularly imprinted polymer (MIP) through the application of diffuse reflectance spectrophotometry (DRS) directly in a slid material.
Flexible electrochemical aptasensor for cortisol detection in human sweat
An inexpensive flexible PDMS@CNC/CNT@aptamer sensor for facile detection of cortisol in human sweat with capacity for use as wearable device.
Iron oxide xerogels for improved water quality monitoring of arsenic(III) in resource-limited environments via solid-phase extraction, preservation, storage, transportation, and analysis of trace contaminants (SEPSTAT)
We show that iron oxide xerogels can quantitatively adsorb, store, and release aqueous arsenic(III), enabling a new arsenic monitoring paradigm where sample contamination is adsorbed onto solid sorbents for transportation to laboratories for analysis.
About this collection
This themed collection features articles published in Analytical Methods marked as HOT by the handling editor or as recommended by referees. Congratulations to all the authors whose articles are featured.