Themed collection 2026 Chinese New Year and Lunar New Year Collection: Chemistry-Biology Interface

Programmable DNA nanostructures enable stimuli-responsive drug delivery and multimodal biosensing. This review highlights their modular design, stability, and precision in disease-targeted therapy and early cancer diagnosis.

This review offers a concise overview of platinum-based anticancer complexes targeting the G-quadruplex, aiming to overcome cisplatin-resistance.

This review provides a comprehensive overview of all FDA-approved drugs containing oxazole and isoxazole nuclei, focusing on their pharmacological activities and structure–activity relationships.

Peptide-based delivery systems advance mRNA therapies for protein replacement, gene editing, and vaccine development.

Allosteric regulation is a fundamental mechanism in enzyme function, enabling dynamic modulation of activity through ligand binding at sites distal to the active site.

This review comprehensively covers recent advancements in electro-organic synthesis for alkene 1,2-difunctionalization, emphasizing various reaction mechanisms, current challenges and possible solutions.

This review highlights the recent advances in multi-component reactions for synthesizing heterocyclic compounds via green approaches including photoredox catalysis, electrochemical activation, catalyst-free methods and use of water as sole solvent.

The sydonol biosynthetic pathway was elucidated, featuring two novel enzymatic reactions: a bisabolene cyclase (Syd1) mediating 1,5-proton transfer and 1,7-hydride shift, and an unusual P450 (Syd2) catalyzing bisabolene aromatization.

A novel 1,4-difunctionalization strategy for the sequential amidation/thioetherification of N-alkyl isoquinolinium iodide salts using thiols/thiophenols as the coupling partners and TBHP as the mediator is disclosed.

SSN exhibits a large Stokes shift and strong fluorescence enhancement, showing viscosity sensitivity only in neutral to alkaline environments, making it a promising tool for studying viscosity-pH dynamics.

A simple method for preparing N-benzyl sulfoximines has been disclosed with broad substrate scope via a cross-dehydrogenative coupling strategy.

Importance of experimental configurations for in vitro mechanical evaluation of microneedle arrays as the first-line investigation of skin insertion potential.

The enzyme inhibitory effect of aloin-Fe₃O₄@rGO nanocomposites and their anti-browning effect and safety.

Site-specific glycan conjugation enables a stable and efficacious biparatopic HER2-targeting ADC.

ZBTB20 binds to the afp and foxO1 promoters, represses their transcription, and regulates hepatocarcinogenesis.

Multidimensional structural and mechanistic analyses elucidate the molecular basis of chuangxinmycin's species-selective inhibition of bacterial tryptophanyl-tRNA synthetases.

An iridium(III) 3-chloro-6-thio-1,2,4,5-tetrazine complex was modified with an RGD peptide, affording a photoactive conjugate that specifically targeted tumour cells and showed enhanced emission and singlet oxygen generation upon photoirradiation.

Centrosomal localization of DLGAP5 mRNA, revealed by MERR APEX-seq, is mediated by nascent MBD1 polypeptides in the polysome during co-translational targeting.

GTB-DAS·2H₂O and GTB-DAS CM were comparatively investigated, and GTB-DAS·2H₂O shows superior stability, tabletability, and dissolution performance, making it a more promising and reliable solid form for the development of combinational therapy.

In this study, a nanoemulsion of a BCS class II drug, fenofibrate, was cross-linked via a Michael-type addition reaction to yield micro-crystalline Fen-embedded micro-hydrogels with tunable degradation.

Therapeutic proteins have drawn increasing attention in the development of advanced drugs and biomedical devices, yet there are outstanding challenges for the delivery of multiple-protein therapies with customized release profiles.

Epigallocatechin-3-gallate (EGCG) is a key bio-active component of green tea and has demonstrated significant antidepressant activity in laboratory animals.

We developed a novel macrocyclic RGD-peptides (2-c) with high selectivity for α_vβ₃ Integrin in specific tumor imaging and therapy via one-pot Srt A-mediated on-resin in situ cyclization strategy.

Cur-CNEs/Gel combines the superior skin penetration efficiency of cell-penetrating peptide modified curcumin-loaded nanoemulsions and the prolonged skin retention ability of the oligopeptide hydrogel.