4-Chloro-2H-chromene-3-carbaldehyde: a valid scaffold in organic synthesis and future molecules for healthcare and energy
Over the past decade, versatile 4-chloro-2H-chromene-3-carbaldehyde scaffolds (CCCS) have gained significant attention. Advances in synthetic methods have facilitated their application in medicinal as well as in materials science.
Review Article
C(sp3)–H halogenation using first-row transition metal catalysts under homogeneous conditions
The direct functionalization of unactivated C–H bonds has emerged as a promising strategy to achieve step-economical, atom-efficient, and environmentally benign chemical processes.
Review Article
Diazo compounds: synthesis, carbene generation and reactivity
Diazo compounds are among the most popular intermediates in organic synthesis owing to the ease and versatility of generation of metal–carbenes.
A gold(III)-catalyzed Conia-ene reaction for the direct synthesis of substituted pyrroles from β-ketopropargyl amines
We disclose a gold-catalyzed conversion of unactivated β-ketopropargyl amines to polysubstituted pyrroles under mild, operationally simple conditions. This protocol was further extended to synthesize indolizine skeleton via a one-pot process.
Beyond structure and activity: targeting class A carbapenemases with monocyclic and bicyclic boronic acids to counter antimicrobial resistance
Bicyclic boronic acids inhibit SME-1 carbapenemase via a unique π–π stacking with His105 and covalent interaction with Ser70.
Three-component tandem benzyl-C(sp3)–H functionalization via thermally generated arynes with phenazine
For the first time, we developed a strategy for three-component tandem benzyl-C(sp3)–H activation via thermally-generated arynes with phenazine without a catalyst.
Communication
Efficient and specific DNA-targeting using single-stranded LNA/MOE mixmers and chimeric Invader:XenoRNA probes
Single-stranded LNA/MOE mixmers and duplexes between intercalator-functionalized oligonucleotides and Xeno RNAs efficiently recognize double-stranded DNA with exceptional binding affinity.
Synthetic approach toward the indole alkaloid TMC-205, 6,7-secoagroclavine, aurantioclavine, clavicipitic acid, and caulindoles A–D
A concise and practical one-pot total synthesis of TMC-205 together with the formal synthesis of a series of novel meroterpenoid natural products was achieved via a super-ideal strategy.
Design and assessment of dimeric trehalose glycolipids as a strategy to enhance Mincle-mediated vaccine adjuvanticity
Dimeric ligands for the macrophage inducible C-type lectin have been synthesised and evaluated in vitro and in vivo. The data provide proof of concept that dimeric Mincle ligands are a new class of potential Mincle-mediated vaccine adjuvants.
Synthesis and evaluation of analogs of tetracyclic Ganoderma alkaloids as inhibitors of the enzyme α-glucosidase
Highly active α-glucosidase inhibitors (up to 41 times more potent than acarbose) were synthesised, mimicking ganocochlearines, tetracyclic Ganoderma alkaloids.
Paper
Chemoselective reduction of α-keto aldehydes by rongalite in water: a metal- and hydride-free approach
A mild, metal- and hydride-free protocol employing inexpensive rongalite in water enables efficient and scalable synthesis of α-hydroxymethyl ketones with excellent chemoselectivity and broad functional group tolerance.
Paper
Heterocyclic scaffold-fused dimethoxy-dibenzocyclooctynes for photoactivatable click chemistry
Heterocyclic scaffold-fusion of dimethoxy-DIBO yields photoactivatable pyrrolidine derivatives with efficient SPAAC reactivity, whereas triazole fusions produce nonreactive fluorophores.
About this collection
This collection brings together all of the research and review articles behind our 2026 journal covers, showcasing the wide range of research found in the journal. If your article has been accepted for publication, and you are interested in highlighting your research on one of our covers, please do contact the Editorial Team for further information.