RSC Advances  

A versatile photoredox-catalyzed three-component sulfonylation of diaryliodonium salts with DABSO and silyl enolates involving the insertion of SO₂ for the synthesis of β-keto sulfones was developed.

Epoxides are oxygen containing three-membered heterocycles which can undergo ring opening reactions. These reactions have been significantly employed in the synthesis of alkaloids and terpenoids-based natural products.

The new classification of APAP combinations (prodrugs, codrugs, and hybrids) was proposed. It makes a better understanding of the SAR studies for new pain relievers research and the design development for the analgesic APAP-based compounds.

Engineering the substrate-binding-helix of the keto-reductase domain of TENS controls chain-length selectivity of the products.

Recently, new pharmaceutical discoveries have become very important for addressing diverse health problems and protecting humanity.

We developed a mild and environmentally friendly electrochemical method for the synthesis of quinazolines and quinazolinones via electrochemical oxidative decarboxylation of α-oxocarboxylic acids.

The fundamentals of bio-orthogonal click chemistry are investigated, while exploring mechanistic intricacies, demonstrating the adaptability and promise of this methodology.

Depression is one of the most mutilating conditions in the world today.

Inspired by the chemical reactivity of apalutamide, an efficient method for N-terminal cysteine bioconjugation with 2-cyanopyridine derivatives has been developed.

Glycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, as well as its derivatives produced through structural modification, exhibit noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial, antiviral, and antioxidant effects.

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

In contrast to previous SAR studies of aza-compounds (23 vs. 24 and 25), the present study using analogues (26a–26c, 27c, and 28a–28c) of salacinol (1) revealed an essential role of the thiosugar ring in effectively inhibiting α-glucosidase.

De novo designed aliphatic and aromatic peptides form biomimetic supramolecular nanofibrils illuminating the intricacies of the pathogenic amyloid assemblies.

This work describes novel transaminase fusions, with potential for converting fatty acids into amines and more complex natural products.

Imidazopyridazines are fused heterocycles, like purines, with a pyridazine ring replacing the pyrimidine ring in purines.

Several pyrazolidine-3-one analogs of (+)-7-iso-jasmonoyl-L-isoleucine, the main phytohormone involved in plant responses to biotic or abiotic stress, were prepared from 4 different building blocks in just a few steps.

Beta-galactosidase (β-galactosidase), a lysosomal hydrolytic enzyme, plays a critical role in the catalytic hydrolysis of glycosidic bonds, leading to the conversion of lactose into galactose.

Synthesis of N-glycosyl amides is proposed from glycosyl azides. Hexose derivatives stereoselectively formed the β anomer, while xylo derivatives produced a mixture of α (¹C₄) and β (⁴C₁) anomers. Free galactose derivatives were moderate inhibitors of E. coli β-galactosidase.

MD simulations pinpointed temperature-sensitive glycine residues in LrInu. Substituting these glycines with proline significantly improved stability and levan yield.

Fused pyrrolo[2,1-a]isoquinolines have emerged as compelling molecules with remarkably potent cytotoxic activity and topoisomerase inhibitors.

Thiazolines and their derivatives hold significant importance in the field of medicinal chemistry due to their promising potential as pharmaceutical agents.

A photocatalytic strategy has been developed for the selective synthesis of (E)-β-aminovinyl sulfones and (E)-β-amidovinyl sulfones through the utilization of allenamides and sodium sulfinates.

α-Lipoic acid (ALA) is a naturally occurring sulfur-containing fatty acid with high antioxidant activity.

The 4-MHA, a key node in the biosynthetic flow of actinomycins under NRPS catalysis, is also converted into actinrhaters A and B.

In this review, we have discussed some features of protein aggregation during production, formulation and storage as well as stabilization strategies in protein engineering and computational methods to prevent aggregation.