RSC Advances  

An anticancer proligand, with AIEE features, demonstrates exceptional binding efficiencies with DNA and SARS-CoV-2 and offers as a promising bioprobe.

A novel phthalazine derivative exhibited potent cytotoxicity against HCT-116 cells as VEGFR2 inhibitor and apoptosis cell death.

New conjugates 1–6 containing 5-dFCR and selected hydroxycinnamic acids were synthesized and tested in vitro against pancreatic cancer (PDAC) lines. The ADME properties and molecular docking to CES2 or human albumin were discussed.

Five new homoleptic derivatives of titanium(IV) have been developed and characterized by physicochemical techniques.

The use of histone deacetylase inhibitors (HDACis) is an effective approach for cancer treatment.

Modified niosomes possessing pH-responsive properties were developed for delivery of antineoplastic agents.

A sequence of novel quinoline-8-yloxy and cinnamide hybrids has been synthesized and evaluated for in vitro cytotoxicity against HepG2 liver cancer cells.

Our study introduces novel symmetrical and asymmetrical dihydropyridines as breast cancer inhibitors, showing cytotoxicity against MCF-7 cells and EGFR kinase inhibition. Molecular docking and dynamics validate superior binding to Lapatinib.

Novel bioactive pyrido[2,3-d]pyrimidine derivatives with potent apoptotic inducers as PIM-1 kinase inhibitors.

Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.

Monoamine oxidases (MAOs) inhibitors could decrease reactive oxygen species (ROS) generation, enhance mono-aminergic neural transmission, and have major therapeutic benefits for the treatment of Alzheimer's disease (AD).

Proaporphine alkaloids—cissamaline, cissamanine, and cissamdine—show promise against AD, with in silico studies highlighting their potential as new therapeutics.

The new classification of APAP combinations (prodrugs, codrugs, and hybrids) was proposed. It makes a better understanding of the SAR studies for new pain relievers research and the design development for the analgesic APAP-based compounds.

DDAH1 inhibitors with diverse chemical structures are needed for the development of new therapeutics in NO related disorders.

The current research discusses the spectroscopic elucidation of the structure and enzymatic activity in silico and in vitro of fifteen known compounds, as well as a new unidentified avenasterol derivative called 21-methylene-24-ethylidene lophenol, from the genus Cassia.

Chromatin-targeting viral peptide–gold(I) conjugates display cancer cell selectivity and localize to the nucleosome acidic patch, forming histone site-specific protein adducts.

Combining sonochemistry with phytochemistry is a modern trend in the biosynthesis of metallic nanoparticles (NPs), which contributes to the sustainability of chemical processes and minimizes hazardous effects.

Two QSAR models which correlates the interaction energy and structural features of agonists and antagonists of M1-AChR.

The heterocyclic (pyrazine)carboxamide Ru(II) complexes interact with CT-DNA through minor groove binding and partial intercalation modes and exhibit significant cytotoxicity and selectivity against A549, PC-3, and Caco-2 cell lines.

Fifteen new iodoquinazoline derivatives, 5a,b to 18, are reported in this study and their anticancer evaluation as dual inhibitors of EGFR^WT and EGFR^T790M.

New phenylisoxazole quinoxalin-2-amine hybrids 5a–i were successfully synthesised with yields of 53–85% and characterised with various spectroscopy methods.

A series of new sulfonamide derivatives connected through an imine linker to five or seven membered heterocycles were designed and synthesized.

Tyrosinase is a widely distributed copper-containing enzyme found in various organisms, playing a crucial role in the process of melanin production.

New pyrazolylindolin-2-one linked coumarin derivatives were designed as dual BRAF^V600E/VEGFR-2 inhibitors targeting melanoma cells A375. Docking simulation showed various interactions with the binding residues in BRAF^V600E and VEGFR-2 active sites.

Some thiophene-based heterocycles were constructed, examined for their antiproliferative activity, and supported by in silico studies.