RSC Advances  

The simple-structured Fabry–Perot interferometric biosensor is capable of rapid and quantitative detection of DNA hybridization.

We have designed and screened seven fully 2′-O-methyl phosphorothioate-modified steric-blocking ASOs for specific inhibition of BIRC5 expression. As a result, ASO-7 was identified as the lead sequence.

Disulfiram (DSF) can target and kill cancer cells by disrupting cellular degradation of extruded proteins and has therefore received particular attention for its tumor chemotherapeutic potential.

Predict SLC6 mutation clinical pathogenicity by calculating the amino acid descriptors in different ranges with rationalization analysis of the prediction.

HA-coated redox sensitive visualized nano-prodrug HA/TPE-CS-SS-PTX were exploited in order to highly efficient treatment of cancer and real-time monitoring of drug localization.

Analytical technique for monitoring skin-emitted metabolites to diagnose diseases.

A versatile probe with mitochondria targeting, PN, for detection of viscosity alteration in HIRI mouse model was fabricated. PN had high sensitivity and selectivity, and with a large Stokes shift (∼190 nm) for viscosity. PN is expected to be used for early diagnosis and treatment assessment of HIRI disease, and also provides diagnostic basis for other related diseases.

Alzheimer has many crucial factors that should be considered in order to get better results from clinical trials. Benzimidazole and its isosteres represent significant scaffolds for designing potential multi-target anti-alzheimer molecules.

The cWIWLYA peptide shows high labeling efficiency with I-131 (>90%). Its ¹³¹I₂-complex has high stability at room temperature as well as in plasma.

This review summarizes the application of various photothermal materials in the detection of circulating tumor cells (CTCs), and describes the significance of CTCs detection for early tumor diagnosis and tumor prognosis.

This review summarized the function of cancer cell membranes and comprehensively discussed the preparation of cancer cell membrane-coated nanoparticles (CCM-NPs) and their application in anti-tumor therapy. The graphical abstract figure was drawn by Figdraw (https://www.figdraw.com).

Messenger RNA (mRNA) is an essential component of cell development and growth.

We constructed a targeted drug platform, ACSN/Fe₃O₄@MSNs-iRGD, that integrates excellent PDT and MRI.

Proaporphine alkaloids—cissamaline, cissamanine, and cissamdine—show promise against AD, with in silico studies highlighting their potential as new therapeutics.

Polymer–DNA assembled nanoflower for targeted delivery of dolastatin-derived microtubule inhibitors was developed, and it exhibited increased cellular uptake and enhanced inhibitory effect, especially in multidrug-resistant tumor cell.

Applications of chemosensors of phase I metabolizing enzymes.

Chromatin-targeting viral peptide–gold(I) conjugates display cancer cell selectivity and localize to the nucleosome acidic patch, forming histone site-specific protein adducts.

By employing a million-level virtual screening to obtain potential PSA compounds and effectively guiding the synthesis using machine learning methods, we obtained lead compounds that exhibited significantly improved binding affinity for PSA.

Recently, new pharmaceutical discoveries have become very important for addressing diverse health problems and protecting humanity.

The rapid emergence of MDR Klebsiella pneumoniae demands alternative therapy. 6-Gingerol is a natural phytocompound that has synergistic and bactericidal effects against MDR-KP isolates. It exhibited promising EPI activity to stop colistin efflux.

This study devised a novel 3D sponge implant containing cisplatin-loaded chitosan–calcium alginate MPs capable of exerting combined chemotherapy and hemostasis effects.

Schematic representation of synthesis process of Folic Acid (FA) conjugated Bovine Serum Albumin (BSA) nanoparticles for the delivery of Fisetin (FST) and its application for cancer treatment.

S. tangutica extract was obtained by medium-pressure liquid chromatography and its activity studied using HPLC-DPPH screening.

Glycyrrhetinic acid, a triterpenoid compound primarily sourced from licorice root, as well as its derivatives produced through structural modification, exhibit noteworthy biological attributes, including anti-inflammatory, anti-tumor, antibacterial, antiviral, and antioxidant effects.

As a novel class of VLP vaccine carrier, the bacteriophage MX1 virus-like particle (VLP) is used for the first time to construct MX1-NHAcGD2 and MX1-NHAcGD3 conjugates. These conjugates can be exciting leads for anticancer vaccines.