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Themed collection Personalised Medicine: Liquid Biopsy

6 articles
Critical Review

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Breakthroughs in adapting microfluidic systems for exosome isolation, detection, and analysis are providing new tools to revolutionize personalized medicine.

Graphical abstract: Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine
From the themed collection: Personalised Medicine: Liquid Biopsy
Critical Review

Novel nanosensing technologies for exosome detection and profiling

This article reviews recent advances of new assay platforms that are developed to facilitate molecular analyses of exosomes.

Graphical abstract: Novel nanosensing technologies for exosome detection and profiling
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Microfluidic isolation of platelet-covered circulating tumor cells

A new CTC isolation approach uncovers special populations of platelet-coated CTCs and CTC-leukocyte clusters in cancer patients.

Graphical abstract: Microfluidic isolation of platelet-covered circulating tumor cells
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis

We have developed a microchip platform that combines fast, magnetic micropore based negative selection (>10 mL h−1) with rapid on-chip in situ RNA profiling.

Graphical abstract: A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Size-tunable microvortex capture of rare cells

A wide distribution of cell sizes can be selectively captured by tuning the flow rate in a micro-vortex flow.

Graphical abstract: Size-tunable microvortex capture of rare cells
From the themed collection: Personalised Medicine: Liquid Biopsy
6 articles

About this collection

Liquid Biopsy, coined by Pantel and Alix-Panabières in 2010, originally referred to real-time analyses of CTCs in cancer. However, that term has since expanded to encompass the analyses of many other disease-related substances found in blood and other body fluids. Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of liquid biopsy technologies. These would include manuscripts related to components that can be captured or characterized from blood such as circulating tumour cells, circulating nucleic acids and circulating extracellular vesicles. This on-going collection is collated by Thought Leaders Mehmet Toner and Stefanie Jeffrey and the Lab on a Chip Editorial Office.

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