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Themed collection Personalised Medicine: Liquid Biopsy

14 items
Perspective

Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics

This review examines scientific advancements of microfluidic technology for engineering exosomes and assesses future applications and perspectives in developing precision therapeutics, which can serve the community by identifying potential new research areas or technologies that are urgently needed in precision therapeutics.

Graphical abstract: Microfluidic engineering of exosomes: editing cellular messages for precision therapeutics
From the themed collection: Lab on a Chip Recent Review Articles
Tutorial Review

Machine learning to detect signatures of disease in liquid biopsies – a user's guide

New technologies that measure sparse molecular biomarkers from easily accessible bodily fluids (e.g. blood, urine, and saliva) are revolutionizing disease diagnostics and precision medicine.

Graphical abstract: Machine learning to detect signatures of disease in liquid biopsies – a user's guide
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

Opportunities and challenges in translational application of ctDNA along with recent developments in chip-based ctDNA detection technologies have been reviewed.

Graphical abstract: Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine

Breakthroughs in adapting microfluidic systems for exosome isolation, detection, and analysis are providing new tools to revolutionize personalized medicine.

Graphical abstract: Microfluidics for exosome isolation and analysis: enabling liquid biopsy for personalized medicine
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Novel nanosensing technologies for exosome detection and profiling

This article reviews recent advances of new assay platforms that are developed to facilitate molecular analyses of exosomes.

Graphical abstract: Novel nanosensing technologies for exosome detection and profiling
From the themed collection: Lab on a Chip Recent Review Articles
Communication

Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy

A microfluidics-enabled strategy for the controllable synthesis of immunomagnetic nanomaterials was developed, and the shape-dependent screening efficiency of CTCs was investigated.

Graphical abstract: Microfluidics-enabled rational design of immunomagnetic nanomaterials and their shape effect on liquid biopsy
From the themed collection: Lab on a Chip Recent HOT Articles
Accepted Manuscript - Paper

Frequency-Enhanced Transferrin Receptor Antibody-Labelled Microfluidic Chip (FETAL-Chip) Enables Efficient Enrichment of Circulating Nucleated Red Blood Cells for Non-invasive Prenatal Diagnosis

From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry

Magnetic ranking cytometry profiles dynamic phenotypes in CTCs that are linked to metastatic potential.

Graphical abstract: Dynamic CTC phenotypes in metastatic prostate cancer models visualized using magnetic ranking cytometry
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection

Single CTC sequencing workflow using biophysical enrichment and single cell isolation by laser capture microdissection.

Graphical abstract: Isolation and genome sequencing of individual circulating tumor cells using hydrogel encapsulation and laser capture microdissection
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring

Fully integrated lab-on-a-disc for cfDNA isolation allows real-time monitoring of tumor mutation status during targeted therapy.

Graphical abstract: Fully automated, on-site isolation of cfDNA from whole blood for cancer therapy monitoring
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Microfluidic isolation of platelet-covered circulating tumor cells

A new CTC isolation approach uncovers special populations of platelet-coated CTCs and CTC-leukocyte clusters in cancer patients.

Graphical abstract: Microfluidic isolation of platelet-covered circulating tumor cells
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis

We have developed a microchip platform that combines fast, magnetic micropore based negative selection (>10 mL h−1) with rapid on-chip in situ RNA profiling.

Graphical abstract: A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Size-tunable microvortex capture of rare cells

A wide distribution of cell sizes can be selectively captured by tuning the flow rate in a micro-vortex flow.

Graphical abstract: Size-tunable microvortex capture of rare cells
From the themed collection: Personalised Medicine: Liquid Biopsy
14 items

About this collection

Liquid Biopsy, coined by Pantel and Alix-Panabières in 2010, originally referred to real-time analyses of CTCs in cancer. However, that term has since expanded to encompass the analyses of many other disease-related substances found in blood and other body fluids. Our goal is to highlight the new advances in this growing field with an emphasis on the interface between the technological advancements and high impact applications of liquid biopsy technologies. These would include manuscripts related to components that can be captured or characterized from blood such as circulating tumour cells, circulating nucleic acids and circulating extracellular vesicles. This on-going collection is collated by Thought Leaders Mehmet Toner and Stefanie Jeffrey and the Lab on a Chip Editorial Office.

More details about the collection and how to apply can be found at rsc.li/blog-liquid-biopsy 

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