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Microfluidic Engineering of Exosomes: Editing Cellular Messages for Precision Therapeutics

Abstract

Studying extracellular vesicle (EV), particularly exosomes, is holding great promise, yet technically challenging in defining such small and molecularly diverse nanovesicles. With intrinsic molecular payload and biodegradability, molecular engineering of exosomes opens new avenues for mediating cellular responses and developing novel nano-delivery systems in precision therapeutics. Microfluidic lab-on-chip technology is taking pivotal roles in such emerging field. This review examines scientific advancements of microfluidic technology for engineering exosomes and assesses future applications and perspectives in developing precision therapeutics, which could serve the community by identifying potential new research areas or technologies that are urgently needed in precision therapeutics.

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Publication details

The article was received on 08 Mar 2018, accepted on 04 May 2018 and first published on 07 May 2018


Article type: Perspective
DOI: 10.1039/C8LC00246K
Citation: Lab Chip, 2018, Accepted Manuscript
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    Microfluidic Engineering of Exosomes: Editing Cellular Messages for Precision Therapeutics

    Q. Zhu, M. E. Heon, Z. Zhao and M. He, Lab Chip, 2018, Accepted Manuscript , DOI: 10.1039/C8LC00246K

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