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Microfluidics-enabled rational design of immunomagnetic nanomaterial and its shape effect in liquid biopsy

Abstract

Microfluidics brings unique opportunities for nanomaterials synthesis toward efficient liquid biopsy. Herein, we developed microreactor-enabled flow synthesis of immunomagnetic nanomaterials with controllable shapes (sphere, cube, rod, and belt) by simply tuning the flow rates. The particle shape-dependent screening efficiency of circulating tumor cells was first investigated and compared with commercial ferrofluid, providing new insights for the rational design of particulate system toward the screening and analysis of circulating tumor biomarkers.

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Publication details

The article was received on 17 Mar 2018, accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Communication
DOI: 10.1039/C8LC00273H
Citation: Lab Chip, 2018, Accepted Manuscript
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    Microfluidics-enabled rational design of immunomagnetic nanomaterial and its shape effect in liquid biopsy

    N. Hao, Y. Nie, T. Shen and J. X. J. Zhang, Lab Chip, 2018, Accepted Manuscript , DOI: 10.1039/C8LC00273H

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