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Themed collection Organ-, body- and disease-on-a-chip systems

19 items
Editorial

Organ-, body- and disease-on-a-chip systems

Thought leader Michael Shuler introduces the Lab on a Chip organ, body and disease on a chip thematic collection.

Graphical abstract: Organ-, body- and disease-on-a-chip systems
From the themed collection: Organ-, body- and disease-on-a-chip systems
Perspective

Organ-on-a-chip devices advance to market

We reviewed the foundational technologies underlying the commercialization efforts of the current prominent organ-on-a-chip start-ups.

Graphical abstract: Organ-on-a-chip devices advance to market
From the themed collection: Organ-, body- and disease-on-a-chip systems
Critical Review

Powering Ex Vivo Tissue Models in Microfluidic Systems

From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Critical Review

Microsensor systems for cell metabolism – from 2D culture to organ-on-chip

We discuss microsensors for cell culture monitoring from 2D culture to organ-on-chip systems, including sensor principles, fabrication and culture formats.

Graphical abstract: Microsensor systems for cell metabolism – from 2D culture to organ-on-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Critical Review

Tumour-vessel-on-a-chip models for drug delivery

In this review, we present the use of tumour-vessels-on-a-chip to investigate and screen nanoparticles for cancer targeted drug delivery.

Graphical abstract: Tumour-vessel-on-a-chip models for drug delivery
From the themed collection: Organ-, body- and disease-on-a-chip systems
Communication

“Open-top” microfluidic device for in vitro three-dimensional capillary beds

We introduce a novel microfluidic device to co-culture a blood vessel network and cell tissues in an in vivo-like niche.

Graphical abstract: “Open-top” microfluidic device for in vitro three-dimensional capillary beds
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

A novel lung airway-on-a-chip system that uses a suspended hydrogel to enable epithelial–matrix–smooth muscle cell interactions.

Graphical abstract: Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Human brain organoid-on-a-chip to model prenatal nicotine exposure

We present a new strategy to generate stem cell based human brain organoids using an organ-on-a-chip system that allows us to model prenatal nicotine exposure.

Graphical abstract: Human brain organoid-on-a-chip to model prenatal nicotine exposure
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing

A PLGA nanofiber membrane supported lung-on-a-chip microdevice was developed to model the alveolar microenvironment for anti-cancer drug testing.

Graphical abstract: Nanofiber membrane supported lung-on-a-chip microdevice for anti-cancer drug testing
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier

This work presents a new microfluidic chip to facilitate multicellular interactions and cell barrier function monitoring in real time.

Graphical abstract: A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood–retinal barrier
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform

A multi-throughput multi-organ-on-a-chip system was formed on a pneumatic pressure-driven medium circulation platform as a novel type of microphysiological system.

Graphical abstract: A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening

Contractility and rate of human stem cell heart tissues.

Graphical abstract: Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.

Graphical abstract: Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

Combined integration of TEER and MEA sensors in a single endothelialized Organ-on-Chip platform.

Graphical abstract: Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Simultaneous electrical recording of cardiac electrophysiology and contraction on chip

We report a new heart-on-chip design capable of electrical stimulation, recording of growth, contraction and activating map from in vitro-cultured human cardiac tissues.

Graphical abstract: Simultaneous electrical recording of cardiac electrophysiology and contraction on chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

A biomimetic glomerulus-on-a-chip microdevice was created to recapitulate a disease model of diabetic nephropathy.

Graphical abstract: A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

In vitro nasal mucosa gland-like structure formation on a chip

The emergence of microfluidic epithelial models using diverse types of cells within a physiologically relevant microenvironment has the potential to be a powerful tool for preclinical drug screening and pathophysiological studies.

Graphical abstract: In vitro nasal mucosa gland-like structure formation on a chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications

A vascularized, perfused organ-on-a-chip platform suitable for large-scale drug efficacy/toxicity screening.

Graphical abstract: A vascularized and perfused organ-on-a-chip platform for large-scale drug screening applications
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Bioprinted thrombosis-on-a-chip

A novel bioprinted model of thrombosis was developed to study thrombosis and thrombolysis in vitro.

Graphical abstract: Bioprinted thrombosis-on-a-chip
From the themed collection: Organ-, body- and disease-on-a-chip systems
19 items

About this collection

A collection of papers and reviews on organ-, body- and disease-on-a-chip research focussing on the interface between the technological advancements and high impact applications of organ-, body- and disease-on-a-chip technologies. This on-going collection is collated by Thought leader Michael Shuler and the Lab on a Chip Editorial Board.

More details about the collection and how to apply can be found at rsc.li/blog-organonachip

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