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Themed collection 2015 Journal of Materials Chemistry B Hot Papers

134 items - Showing page 1 of 2
Highlight

High-density lipoproteins for therapeutic delivery systems

High-density lipoproteins are a class of natural nanostructures with multiple desirable properties to model in a drug delivery vehicle. Here we review the structure and function of high-density lipoproteins, and their use as therapeutic delivery systems.

Graphical abstract: High-density lipoproteins for therapeutic delivery systems
Highlight

The evolution of fibrin-specific targeting strategies

A variety of antibodies, antibody fragments, and small peptides have been engineered to specifically target fibrin over its precursor fibrinogen.

Graphical abstract: The evolution of fibrin-specific targeting strategies
Review Article

Biomolecular strategies to modulate the macrophage response to implanted materials

Materials engineered to display immunomodulatory molecules including adhesion ligands, cytokines, and self-proteins, target receptors on immune cells to modulate their response to biomaterial implants.

Graphical abstract: Biomolecular strategies to modulate the macrophage response to implanted materials
Review Article

Cellular modulation by the elasticity of biomaterials

The elasticity of the extracellular matrix has been increasingly recognized as a dominating factor of cell fate and activities. This review provides an overview of the general principles and recent advances in the field of matrix elasticity-dependent regulation of a variety of cellular activities and functions, the underlying biomechanical and molecular mechanisms, as well as the pathophysiological implications.

Graphical abstract: Cellular modulation by the elasticity of biomaterials
Review Article

Biomaterials for in situ tissue regeneration: development and perspectives

Biomaterials are of fundamental importance to in situ tissue regeneration, which has emerged as a powerful method to treat tissue defects. The development and perspectives of biomaterials for in situ tissue regeneration were summarized.

Graphical abstract: Biomaterials for in situ tissue regeneration: development and perspectives
Review Article

Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells

Differentiation methods of hPSCs into specific cell lineages. Differentiation of hPSCs via EB formation (types AB, A–D) or without EB formation (types E–H).

Graphical abstract: Physical cues of cell culture materials lead the direction of differentiation lineages of pluripotent stem cells
Review Article

Hyaluronic acid and neural stem cells: implications for biomaterial design

While in the past hyaluronic acid (HA) was considered a passive structural component, research over the past few decades has revealed its diverse and complex biological functions resulting in a major ideological shift. This review describes recent advances in biological interactions of HA with neural stem cells, with a focus on leveraging these interactions to develop advanced biomaterials that aid regeneration of the central nervous system.

Graphical abstract: Hyaluronic acid and neural stem cells: implications for biomaterial design
Review Article

The influence of polymer architecture on in vitro pDNA transfection

In the field of polymer-based gene delivery, the tuning potential of polymers by using different architectures like graft- and star-shaped polymers as well as self-assembled block copolymers is immense. In the last years numerous new polymer designs showed enhanced transfections properties in combination with a good biocompatibility.

Graphical abstract: The influence of polymer architecture on in vitro pDNA transfection
Review Article

Understanding cell homing-based tissue regeneration from the perspective of materials

The triad of cell homing-based tissue engineering.

Graphical abstract: Understanding cell homing-based tissue regeneration from the perspective of materials
Review Article

The role of tissue engineering in cellular therapies for myocardial infarction: a review

Current medical treatments of myocardial infarction (MI) face a serious shortcoming in that they cannot reverse the detrimental effects of ischemia induced necrosis.

Graphical abstract: The role of tissue engineering in cellular therapies for myocardial infarction: a review
Review Article

Design of hybrid nanovehicles for remotely triggered drug release: an overview

This review addresses the advantages of remote triggers, e.g. ultrasounds, near infrared light and alternating magnetic fields, the fabrication of the hybrid nanovehicles, the release mechanisms and the next challenges.

Graphical abstract: Design of hybrid nanovehicles for remotely triggered drug release: an overview
Open Access Review Article

The potential of nanoparticles for the immunization against viral infections

Vaccination has a great impact on the prevention and control of infectious diseases. Nanoparticles can deliver immunoactive biomolecules to induce a virus-specific immune response.

Graphical abstract: The potential of nanoparticles for the immunization against viral infections
Review Article

An overview of the suitability of hydrogel-forming polymers for extrusion-based 3D-printing

In this review hydrogel-forming polymers that are suitable for extrusion-based 3D printing are evaluated.

Graphical abstract: An overview of the suitability of hydrogel-forming polymers for extrusion-based 3D-printing
Review Article

Fundamentals of double network hydrogels

Double network (DN) hydrogels as promising soft-and-tough materials intrinsically possess extraordinary mechanical strength and toughness due to their unique contrasting network structures, strong interpenetrating network entanglement, and efficient energy dissipation.

Graphical abstract: Fundamentals of double network hydrogels
Review Article

Amelogenin and enamel biomimetics

Mature tooth enamel is acellular and does not regenerate itself.

Graphical abstract: Amelogenin and enamel biomimetics
Review Article

Rational design and applications of conducting polymer hydrogels as electrochemical biosensors

Conducting polymer hydrogels (CPHs) are conducting polymer-based materials that contain high water content and have physical properties, resembling the extracellular environment.

Graphical abstract: Rational design and applications of conducting polymer hydrogels as electrochemical biosensors
Review Article

Engineering and functionalization of biomaterials via surface modification

Recent progress pertaining to the surface treatment of implantable macro-scale biomaterials and using micro- and nano-biomaterials for disease diagnosis and drug/gene delivery is reviewed.

Graphical abstract: Engineering and functionalization of biomaterials via surface modification
Review Article

Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures

We discuss covalently cross-linked poly(2-oxazoline)s including gels, nanogels and capsules on the basis of their synthetic origin in a biomedical context.

Graphical abstract: Covalently cross-linked poly(2-oxazoline) materials for biomedical applications – from hydrogels to self-assembled and templated structures
Communication

Conversion of titania (TiO2) into conductive titanium (Ti) nanotube arrays for combined drug-delivery and electrical stimulation therapy

The conversion of titania (TiO2) nanotubes into titanium (Ti), while preserving their nanotubular structures is demonstrated for proposed application as bone implants and electrodes for combined local drug delivery and electrical stimulation therapy.

Graphical abstract: Conversion of titania (TiO2) into conductive titanium (Ti) nanotube arrays for combined drug-delivery and electrical stimulation therapy
Communication

Aggregation induced emission amphiphile with an ultra low critical micelle concentration: fabrication, self assembling, and cell imaging

An AIE-active amphiphile containing a tetraphenylethene moiety and a quarternary ammonium salt group, with an ultra low CMC, desirable optical properties, good water dispersibility and excellent biocompatibility, was prepared and investigated, and the as-prepared amphiphile was successfully applied in cell imaging.

Graphical abstract: Aggregation induced emission amphiphile with an ultra low critical micelle concentration: fabrication, self assembling, and cell imaging
Communication

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Patterning of encapsulated MSCs for the spatio-temporal guidance of angiogenesis for modelling and design of therapeutic biomaterials.

Graphical abstract: Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis
Communication

Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery

With inspirations from natural viruses, arginine-containing dendritic lipopeptides were designed for bioinspired fabrication.

Graphical abstract: Virus-inspired mimics: self-assembly of dendritic lipopeptides into arginine-rich nanovectors for improving gene delivery
Open Access Communication

A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells

A target-specific switchable fluorescent probe for cellular Mdm2 protein detection (off–on) and drug discovery applications (on–off) targeting the p53 pathway.

Graphical abstract: A highly sensitive fluorescent light-up probe for real-time detection of the endogenous protein target and its antagonism in live cells
Communication

Revealing the direct effect of individual intercalations on DNA conductance toward single-molecule electrical biodetection

The effect of individual intercalations on DNA conductance is revealed electrically at the single-molecule level by using DNA-functionalized molecular junctions.

Graphical abstract: Revealing the direct effect of individual intercalations on DNA conductance toward single-molecule electrical biodetection
Communication

Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation

Two azide-functionalized AIE fluorogens are synthesized and used for detecting S-phase DNA synthesis and cell proliferation based on EdU assay.

Graphical abstract: Photostable AIE fluorogens for accurate and sensitive detection of S-phase DNA synthesis and cell proliferation
Communication

Rapid microwave-assisted synthesis of ultra-bright fluorescent carbon dots for live cell staining, cell-specific targeting and in vivo imaging

Ultra-bright fluorescent carbon dots were rapidly synthesized for multifunctional bio-imaging including live cell staining, cell-specific targeting and in vivo imaging.

Graphical abstract: Rapid microwave-assisted synthesis of ultra-bright fluorescent carbon dots for live cell staining, cell-specific targeting and in vivo imaging
Communication

Modified chitosan emulsifiers: small compositional changes produce vastly different high internal phase emulsion types

By varying the oligolysine units of chitosan-graft-oligoNIPAM-graft-oligolysine, high internal phase emulsions of different droplet sizes can be stabilized which can subsequently serve as template for macroporous polymers.

Graphical abstract: Modified chitosan emulsifiers: small compositional changes produce vastly different high internal phase emulsion types
Communication

Highly stretchable and super tough nanocomposite physical hydrogels facilitated by the coupling of intermolecular hydrogen bonds and analogous chemical crosslinking of nanoparticles

Nanocomposite physical hydrogels fabricated by a one-step polymerization show ultra-extensibility and toughness due to an effective strengthening mechanism.

Graphical abstract: Highly stretchable and super tough nanocomposite physical hydrogels facilitated by the coupling of intermolecular hydrogen bonds and analogous chemical crosslinking of nanoparticles
Communication

Functional silsesquioxane-based hierarchical assemblies for antibacterial/antifungal coatings

This paper reports the first study on functional silsesquioxane-based hierarchical assemblies containing an ordered distribution of silver nanoparticles with a large number of {111} facets, obtained through sol–gel reaction, intended for antibacterial/antifungal coatings.

Graphical abstract: Functional silsesquioxane-based hierarchical assemblies for antibacterial/antifungal coatings
Open Access Communication

Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests

Two core–shell nanoparticles with a polyglycerol shell and sp3 carbon core but different core flexibilities were synthesized and compared for their encapsulation capacities.

Graphical abstract: Carbon-based cores with polyglycerol shells – the importance of core flexibility for encapsulation of hydrophobic guests
Communication

Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture

Compartmentalized hydrogel microparticles with high production rate, uniform size and shape, and tunable ECM support were developed for various scalable 3D cell culture applications.

Graphical abstract: Designing compartmentalized hydrogel microparticles for cell encapsulation and scalable 3D cell culture
Paper

The effect of PEGylation on the stimulation of IL-1β by gold (Au) nanoshell/silica core nanoparticles

PEGylation of Au nanoshell/silica core (GNS) particles reduces the aggregation in cell culture and the generation of IL-1β and the influx of neutrophils in the mouse peritoneal cavity.

Graphical abstract: The effect of PEGylation on the stimulation of IL-1β by gold (Au) nanoshell/silica core nanoparticles
Paper

Surface micropatterning with zirconia and calcium phosphate ceramics by micromoulding in capillaries

Micropatterning of silicon surface with bioinert yttria-stabilised zirconia or bioactive calcium phosphate ceramic by micromoulding in capillaries.

Graphical abstract: Surface micropatterning with zirconia and calcium phosphate ceramics by micromoulding in capillaries
Paper

Electrospun fibers of chitosan-grafted polycaprolactone/poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) blends

CS-g-PCL/PHBHHx fiber blends show an optimal combination of strength, ductility, antibacterial activity and non-cytotoxicity, and thus are suitable as scaffolds for tissue engineering.

Graphical abstract: Electrospun fibers of chitosan-grafted polycaprolactone/poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) blends
Paper

Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI/photoacoustic imaging and photodynamic/photothermal dual-modal therapeutic agents for liver cancer

Semiconducting polymer dot micelles for MRI/photoacoustic imaging and single-laser-induced PDT/PTT therapy.

Graphical abstract: Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI/photoacoustic imaging and photodynamic/photothermal dual-modal therapeutic agents for liver cancer
Paper

Investigating the potential of human placenta-derived extracellular matrix sponges coupled with amniotic membrane-derived stem cells for osteochondral tissue engineering

Placental extracellular matrix for osteochondral defects.

Graphical abstract: Investigating the potential of human placenta-derived extracellular matrix sponges coupled with amniotic membrane-derived stem cells for osteochondral tissue engineering
Paper

In vitro degradation and angiogenesis of the porous calcium silicate–gelatin composite scaffold

Calcium silicate-gelatin scaffolds stimulated the release of angiogenesis factors such as von Willebrand factor and angiopoietin-1 more than the calcium silicate scaffold.

Graphical abstract: In vitro degradation and angiogenesis of the porous calcium silicate–gelatin composite scaffold
Paper

Different chemical strategies to aminate oxidised multi-walled carbon nanotubes for siRNA complexation and delivery

The carboxylic groups of oxidised multi-walled carbon nanotubes were directly converted into amino functions without extending the lateral chain. These nanotubes have been investigated as carriers for siRNA delivery.

Graphical abstract: Different chemical strategies to aminate oxidised multi-walled carbon nanotubes for siRNA complexation and delivery
Paper

Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer

Cross-linked polymeric nanoassemblies are potential carrier systems for cytotoxic ruthenium complexes, and exhibit a combination of electrostatic and hydrophobic interactions with the metal complexes that impact release rates, release percentages, and biological activity.

Graphical abstract: Light-sensitive ruthenium complex-loaded cross-linked polymeric nanoassemblies for the treatment of cancer
Open Access Paper

High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite

Metastable amorphous calcium carbonate (ACC), formed as a precursor of crystalline carbonated apatite/hydroxyapatite in human bone, can be stabilized by inorganic polyphosphate. The resulting CaCO3/polyP, containing small amounts of vaterite, has osteogenic potential and potential application as a scaffold material for bone implants.

Graphical abstract: High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite
Paper

Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery

The contribution of the surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery, including adsorption, sustained release, cellular uptake and endo/lysosomal escape.

Graphical abstract: Understanding the contribution of surface roughness and hydrophobic modification of silica nanoparticles to enhanced therapeutic protein delivery
Paper

Regulating the stemness of mesenchymal stem cells by tuning micropattern features

The stemness of MSCs was significantly influenced by cell morphogenesis regulated by micropatterns, and was always accompanied with change of nuclear activity and cytoskeleton mediated nanomechanics.

Graphical abstract: Regulating the stemness of mesenchymal stem cells by tuning micropattern features
Paper

Synthesis and characterization of waterborne polyurethane containing poly(3-hydroxybutyrate) as new biodegradable elastomers

Poly(3-hydroxybutyrate) (PHB) is a biodegradable polymer with good biocompatibility.

Graphical abstract: Synthesis and characterization of waterborne polyurethane containing poly(3-hydroxybutyrate) as new biodegradable elastomers
Paper

An acid-free microwave approach to prepare highly luminescent boron-doped graphene quantum dots for cell imaging

Highly luminescent graphene quantum dots (GQDs) are obtained by restoring the defects of GQDs via incorporation of B atoms into the graphene framework, which exhibits great potential in bio-imaging.

Graphical abstract: An acid-free microwave approach to prepare highly luminescent boron-doped graphene quantum dots for cell imaging
Paper

A versatile pH-responsive platform for intracellular protein delivery using calcium phosphate nanoparticles

A highly biocompatible nanoplatform for the intracellular delivery of different proteins, exhibiting pH-responsive release and efficient endosomal escape.

Graphical abstract: A versatile pH-responsive platform for intracellular protein delivery using calcium phosphate nanoparticles
Paper

Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors

Hyaluronic acid-modified Fe3O4/Au composite nanoparticles can be synthesized for targeted dual mode MR/CT imaging of tumors.

Graphical abstract: Facile synthesis of hyaluronic acid-modified Fe3O4/Au composite nanoparticles for targeted dual mode MR/CT imaging of tumors
Open Access Paper

Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells

Herein, we report the synthesis and characterization of nanospheres of a biodegradable zinc-imidazolate polymers (ZIPs) as a proof-of-concept delivery vehicle into human brain endothelial cells, the main component of the blood-brain barrier (BBB).

Graphical abstract: Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells
Paper

Good hydration and cell-biological performances of superparamagnetic calcium phosphate cement with concentration-dependent osteogenesis and angiogenesis induced by ferric iron

Superparamagnetic Fe3+-doped calcium phosphate cement (Fe-CPC) has prospective applications in bone remodeling due to its good hydration properties and significant effect on osteogenesis and angiogenesis.

Graphical abstract: Good hydration and cell-biological performances of superparamagnetic calcium phosphate cement with concentration-dependent osteogenesis and angiogenesis induced by ferric iron
Paper

Heparin-based temperature-sensitive injectable hydrogels for protein delivery

Polysaccharide-based biodegradable, biocompatible and temperature-sensitive injectable hydrogels have been developed for the sustained delivery of proteins.

Graphical abstract: Heparin-based temperature-sensitive injectable hydrogels for protein delivery
Paper

Novel protein-loaded chondroitin sulfate-N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan nanoparticles with reverse zeta potential: preparation, characterization, and ex vivo assessment

Positively and negatively surface charged nanoparticles were prepared by a facile PEC method composed of chondroitin sulfate and N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan.

Graphical abstract: Novel protein-loaded chondroitin sulfate-N-[(2-hydroxy-3-trimethylammonium)propyl]chitosan nanoparticles with reverse zeta potential: preparation, characterization, and ex vivo assessment
Paper

Effect of direct loading of phytoestrogens into the calcium phosphate scaffold on osteoporotic bone tissue regeneration

3D porous calcium deficient hydroxyapatite scaffolds with phytoestrogens were fabricated for osteoporotic bone tissue regeneration through a combination of 3D printing techniques and cement chemistry as a room temperature process.

Graphical abstract: Effect of direct loading of phytoestrogens into the calcium phosphate scaffold on osteoporotic bone tissue regeneration
Paper

Prevention of surface-induced thrombogenesis on poly(vinyl chloride)

PVC is derivatized with an ultrathin MEG coating with remarkable antithrombogenicity. Assessed upon exposure to fluorescently-labelled human blood, at various shear rates and contact periods, platelet aggregation/clotting coverage is reduced by >95–99% for coated vs. bare PVC surfaces.

Graphical abstract: Prevention of surface-induced thrombogenesis on poly(vinyl chloride)
Paper

Surface coatings with covalently attached caspofungin are effective in eliminating fungal pathogens

In this work we have prepared surface coatings formulated with the antifungal drug caspofungin, an approved pharmaceutical lipopeptide compound of the echinocandin drug class.

Graphical abstract: Surface coatings with covalently attached caspofungin are effective in eliminating fungal pathogens
Paper

Single component thermo-gelling electroactive hydrogels from poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone)-graft-aniline tetramer amphiphilic copolymers

Single component injectable degradable conductive hydrogels with excellent biocompatibility based on poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone) and aniline tetramer were prepared via a thermo-gelling approach.

Graphical abstract: Single component thermo-gelling electroactive hydrogels from poly(caprolactone)–poly(ethylene glycol)–poly(caprolactone)-graft-aniline tetramer amphiphilic copolymers
Paper

Design of a versatile nanocomposite for ‘seeing’ drug release and action behavior

To design a new method for ‘seeing’ drug release and action behavior, we combined a rare-earth complex with a magnetic-core-coated phenyl mesoporous silica nanoparticles matrix, taking advantage of the drug coordination for real-time monitoring.

Graphical abstract: Design of a versatile nanocomposite for ‘seeing’ drug release and action behavior
Paper

In vitro biocompatibility of mesoporous metal (III; Fe, Al, Cr) trimesate MOF nanocarriers

The high porosity and versatile composition of the benchmarked mesoporous metal (Fe, Al, Cr) trimesate metal–organic frameworks (MIL-100(Fe, Al, Cr)) make them very promising solids in different strategic industrial and societal domains (separation, catalysis, biomedicine, etc.).

Graphical abstract: In vitro biocompatibility of mesoporous metal (III; Fe, Al, Cr) trimesate MOF nanocarriers
Paper

Plasmon-induced hyperthermia: hybrid upconversion NaYF4:Yb/Er and gold nanomaterials for oral cancer photothermal therapy

Bi-functional nanocomposites consisting of upconversion nanoparticles and gold nanoparticles or gold nanorods are fabricated for oral cancer cell photothermal therapy.

Graphical abstract: Plasmon-induced hyperthermia: hybrid upconversion NaYF4:Yb/Er and gold nanomaterials for oral cancer photothermal therapy
Paper

Facile synthesis of yolk–shell silica nanoparticles for targeted tumor therapy

Redox-responsive yolk–shell silica nanoparticles end-capped with rotaxane nanovalves were fabricated for targeted tumor therapy with high efficiency.

Graphical abstract: Facile synthesis of yolk–shell silica nanoparticles for targeted tumor therapy
Paper

Bioengineered mussel glue incorporated with a cell recognition motif as an osteostimulating bone adhesive for titanium implants

An engineered mussel glue MAP-RGD can be successfully used as a novel functional osteostimulating bone adhesive for titanium implants through improved osteoblastic cell behaviors, blood responses, and eventually enhanced bone regeneration.

Graphical abstract: Bioengineered mussel glue incorporated with a cell recognition motif as an osteostimulating bone adhesive for titanium implants
Paper

Multifunctional REDV-conjugated zwitterionic polycarboxybetaine–polycaprolactone hybrid surfaces for enhanced antibacterial activity, anti-thrombogenicity and endothelial cell proliferation

Multifunctional PCL hybrid surfaces are developed by grafting of REDV–zwitterionic polycarboxybetaine conjugates via surface-initiated ATRP.

Graphical abstract: Multifunctional REDV-conjugated zwitterionic polycarboxybetaine–polycaprolactone hybrid surfaces for enhanced antibacterial activity, anti-thrombogenicity and endothelial cell proliferation
Paper

pH-Sensitive pullulan–DOX conjugate nanoparticles for co-loading PDTC to suppress growth and chemoresistance of hepatocellular carcinoma

Co-delivery of DOX and PDTC using pH-sensitive pullulan–DOX conjugate nanoparticles helped to suppress growth and chemoresistance of hepatocellular carcinoma.

Graphical abstract: pH-Sensitive pullulan–DOX conjugate nanoparticles for co-loading PDTC to suppress growth and chemoresistance of hepatocellular carcinoma
Paper

Swim bladder collagen forms hydrogel with macroscopic superstructure by diffusion induced fast gelation

Type I collagen extracted from the swim bladder of Bester sturgeon forms an oriented hydrogel with mechanical and thermal stability by diffusion induced fast gelation.

Graphical abstract: Swim bladder collagen forms hydrogel with macroscopic superstructure by diffusion induced fast gelation
Paper

Vesicle-like nanospheres of amorphous calcium phosphate: sonochemical synthesis using the adenosine 5′-triphosphate disodium salt and their application in pH-responsive drug delivery

Amorphous calcium phosphate vesicle-like nanospheres synthesized sonochemically using ATP can be used as pH-responsive drug nanocarriers.

Graphical abstract: Vesicle-like nanospheres of amorphous calcium phosphate: sonochemical synthesis using the adenosine 5′-triphosphate disodium salt and their application in pH-responsive drug delivery
Paper

Multiple noncovalent interactions mediated one-pot therapeutic assemblies for the effective treatment of atherosclerosis

Therapeutic microspheres are engineered by multiple noncovalent interactions mediated one-pot assembly, which may serve as effective and safe therapeutics for atherosclerosis.

Graphical abstract: Multiple noncovalent interactions mediated one-pot therapeutic assemblies for the effective treatment of atherosclerosis
Paper

Narrow band gap conjugated polyelectrolytes for photothermal killing of bacteria

We report the demonstration of antimicrobial conjugated polyelectrolytes (CPEs) with high NIR absorbance for selective and efficient photothermal killing of bacteria over mammalian cells.

Graphical abstract: Narrow band gap conjugated polyelectrolytes for photothermal killing of bacteria
Open Access Paper

Gene silencing of the pro-inflammatory cytokine TNF-α with siRNA delivered by calcium phosphate nanoparticles, quantified by different methods

The expression of the proinflammatory cytokine TNF-α was efficiently downregulated with nanoparticles, opening a way to combat inflammatory reactions.

Graphical abstract: Gene silencing of the pro-inflammatory cytokine TNF-α with siRNA delivered by calcium phosphate nanoparticles, quantified by different methods
Paper

New imaging reagents for lipid dense regions in live cells and the nucleus in fixed MCF-7 cells

Specific imaging of lipid dense regions of live MCF-7 cells is achieved with two new Ru(II)-polypyridyl complexes 1 and 2. These visible light excitable reagents are stable towards photo-bleaching and large Stokes shifts are observed. Interestingly, these reagents were localized in the cell nucleus in PFA fixed MCF-7 cells.

Graphical abstract: New imaging reagents for lipid dense regions in live cells and the nucleus in fixed MCF-7 cells
Paper

A zinc complex of a neutral pyridine-based amphiphile: a highly efficient and potentially therapeutic bactericidal material

The complexation of Zn(II) with a neutral pyridine-based amphiphile generates a potent bactericidal material for potential antibacterial and antibiofilm therapy.

Graphical abstract: A zinc complex of a neutral pyridine-based amphiphile: a highly efficient and potentially therapeutic bactericidal material
Paper

Boron ketoiminate-based conjugated polymers with tunable AIE behaviours and their applications for cell imaging

A series of AIE-active D–A type conjugated polymers incorporating boron ketoiminate units were synthesized and applied for cell imaging.

Graphical abstract: Boron ketoiminate-based conjugated polymers with tunable AIE behaviours and their applications for cell imaging
Paper

Ultra-bright near-infrared-emitting HgS/ZnS core/shell nanocrystals for in vitro and in vivo imaging

Novel ultra-bright, stable NIR-emitting HgS/ZnS core/shell NCs with good biocompatibility for in vitro and in vivo imaging.

Graphical abstract: Ultra-bright near-infrared-emitting HgS/ZnS core/shell nanocrystals for in vitro and in vivo imaging
134 items - Showing page 1 of 2

About this collection

This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2015 marked as HOT, as recommended by referees. Congratulations to all the authors whose articles are featured!

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