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Issue 24, 2015
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The potential of nanoparticles for the immunization against viral infections

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Abstract

Vaccination has a great impact on the prevention and control of infectious diseases. However, there are still many infectious diseases for which an effective vaccine is missing. Thirty years after the discovery of the AIDS-pathogen (human immunodeficiency virus, HIV) and intensive research, there is still no protective immunity against the HIV infection. Over the past decade, nanoparticulate systems such as virus-like particles, liposomes, polymers and inorganic nanoparticles have received attention as potential delivery vehicles which can be loaded or functionalized with active biomolecules (antigens and adjuvants). Here we compare the properties of different nanoparticulate systems and assess their potential for the development of new vaccines against a range of viral infections.

Graphical abstract: The potential of nanoparticles for the immunization against viral infections

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Publication details

The article was received on 04 Apr 2015, accepted on 14 May 2015 and first published on 14 May 2015


Article type: Review Article
DOI: 10.1039/C5TB00618J
Citation: J. Mater. Chem. B, 2015,3, 4767-4779
  • Open access: Creative Commons BY-NC license
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    The potential of nanoparticles for the immunization against viral infections

    V. Sokolova, A. M. Westendorf, J. Buer, K. Überla and M. Epple, J. Mater. Chem. B, 2015, 3, 4767
    DOI: 10.1039/C5TB00618J

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