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Themed collection Novel Antibiotics and Antimicrobial Resistance

12 items
Editorial

Editorial: Are natural products the solution to antimicrobial resistance?

Graphical abstract: Editorial: Are natural products the solution to antimicrobial resistance?
Viewpoint

Opportunities for natural products in 21st century antibiotic discovery

Natural product research is poised to regain prominence in delivering new drugs to solve the antibiotic crisis.

Graphical abstract: Opportunities for natural products in 21st century antibiotic discovery
Viewpoint

Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

Antibiotics are a therapeutic class that, once deployed, select for resistant bacterial pathogens and so shorten their useful life cycles.

Graphical abstract: Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?
Highlight

Proline-rich antimicrobial peptides targeting protein synthesis

Proline-rich antimicrobial peptides (PrAMPs) bind within the exit tunnel of the ribosome and inhibit translation elongation. Structures of ribosome-bound PrAMPs reveal the interactions with ribosomal components and could pave the way for the development of novel peptide-based antimicrobial agents.

Graphical abstract: Proline-rich antimicrobial peptides targeting protein synthesis
Review Article

Antibiotics and specialized metabolites from the human microbiota

Human microbiota associated with each body site produce specialized molecules to kill human pathogens. Advanced bioinformatics tools will help to discover unique microbiome chemistry.

Graphical abstract: Antibiotics and specialized metabolites from the human microbiota
Review Article

Actinomycetes: still a source of novel antibiotics

An update on last ten years of actinomycetes antibiotic discovery, including recent key molecules in clinical development and overlooked compounds discovered using novel strategies.

Graphical abstract: Actinomycetes: still a source of novel antibiotics
Review Article

Targeting a cell wall biosynthesis hot spot

History points to the bacterial cell wall biosynthetic network as a very effective target for antibiotic intervention, and numerous natural product inhibitors have been discovered.

Graphical abstract: Targeting a cell wall biosynthesis hot spot
Review Article

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

Gram-negative bacteria are a rich and underexplored source of antibiotics that are assembled via remarkably diverse biosynthetic pathways.

Graphical abstract: Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
Review Article

Recent advances and perspectives in the design and development of polymyxins

Polymyxins: background and future perspectives. Introducing metabolism and detoxification considerations into the design of new polymyxins to reduce nephrotoxicity.

Graphical abstract: Recent advances and perspectives in the design and development of polymyxins
Review Article

Symbiosis-inspired approaches to antibiotic discovery

Advances in our understanding of symbioses, enabled by newly developed “omics” and co-culturing technologies, inspire new approaches to antibiotic discovery.

Graphical abstract: Symbiosis-inspired approaches to antibiotic discovery
Review Article

Bifunctional antimicrobial conjugates and hybrid antimicrobials

Novel antimicrobial drugs are continuously needed to counteract bacterial resistance development.

Graphical abstract: Bifunctional antimicrobial conjugates and hybrid antimicrobials
Open Access Review Article

Conformational control of the bacterial Clp protease by natural product antibiotics

Natural products targeting the bacterial Clp protease unravel key interfaces for protein–protein–interaction and long-distance conformational control.

Graphical abstract: Conformational control of the bacterial Clp protease by natural product antibiotics
12 items

About this collection

Natural Product Reports is delighted to publish a collection of reviews focussing on novel antibiotics and antimicrobial resistance. Guest Edited by Bradley S. Moore, Guy T. Carter and Mark Brönstrup, this collection brings insight into the role of natural products play in alleviating the increasing issue of antimicrobial resistance.

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