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Themed collection Bioinspired systems in supramolecular chemistry and nanotechnology

18 articles
Editorial

Bioinspired systems in supramolecular chemistry and nanotechnology – introducing the SupraBio themed issue

Welcome to this issue of New Journal of Chemistry featuring the themed issue “Bioinspired systems in supramolecular chemistry and nanotechnology”.

Graphical abstract: Bioinspired systems in supramolecular chemistry and nanotechnology – introducing the SupraBio themed issue
Perspective

Cationic liposome–nucleic acid complexes for gene delivery and gene silencing

The evolution of liposomes highlighting surface functionalization: from naked and PEGylated liposomes to PEGylated cationic liposome–nucleic acid nanoparticles for therapeutics.

Graphical abstract: Cationic liposome–nucleic acid complexes for gene delivery and gene silencing
Perspective

Bioinspired nanoarchitectonics as emerging drug delivery systems

Bioinspired nanoarchitectonics opens a new era for designing drug delivery systems.

Graphical abstract: Bioinspired nanoarchitectonics as emerging drug delivery systems
Perspective

Supramolecular immobilization of bio-entities for bioelectrochemical applications

Supramolecular systems based on host-guest, electrostatic, or metal-ligand interaction and their use in bioelectrochemical applications are reviewed.

Graphical abstract: Supramolecular immobilization of bio-entities for bioelectrochemical applications
Focus

Self-assembly of fatty acids: from foams to protocell vesicles

Stable aqueous dispersions of fatty acids can now be obtained and yield multiple applications.

Graphical abstract: Self-assembly of fatty acids: from foams to protocell vesicles
Focus

Compartmentalised chemistry: from studies on the origin of life to engineered biochemical systems

Splitting chemical reactions into microscale compartments is one of the greatest inventions of chemical evolution.

Graphical abstract: Compartmentalised chemistry: from studies on the origin of life to engineered biochemical systems
Focus

A hybrid lipid oligonucleotide: a versatile tool for supramolecular chemistry

Lipid oligonucleotides (LONs) self-assemble into supramolecular structures. This property has an impact on the biological effects of the oligonucleotide sequences.

Graphical abstract: A hybrid lipid oligonucleotide: a versatile tool for supramolecular chemistry
Focus

Guanosine and isoguanosine derivatives for supramolecular devices

Guanosine (G) and isoguanosine (isoG) derivatives can self-assemble, yielding supramolecules that have found broad applications in diverse fields.

Graphical abstract: Guanosine and isoguanosine derivatives for supramolecular devices
Letter

A reversible supramolecular assembly containing ionic interactions and disulfide linkages

A reversible ionic supramolecular assembly is described which can be disrupted and reformed by application of either a heating–cooling cycle or a mild redox reaction.

Graphical abstract: A reversible supramolecular assembly containing ionic interactions and disulfide linkages
Open Access Letter

DNA-controlled aggregation of virus like particles – mimicking a tetherin-like mechanism

Lipophilic DNA with two α-tocopherol anchors, mimicking tetherin, a cell protein reducing spreading of viruses, induces aggregation of virus-like particles.

Graphical abstract: DNA-controlled aggregation of virus like particles – mimicking a tetherin-like mechanism
Paper

Diastereoselective self-assembly of clofarabine lipids

Clofarabine lipids form superstructures via diastereoselective self-assembly.

Graphical abstract: Diastereoselective self-assembly of clofarabine lipids
Paper

EPR based distance measurement in Cu-porphyrin–DNA

Measurement of EPR spectra of Cu-porphyrin–DNA reveals intermolecular interactions between the DNA strands with average distances of 6.5–8.9 Å.

Graphical abstract: EPR based distance measurement in Cu-porphyrin–DNA
Paper

Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities

The self-assembling and gene transfer capabilities of monodisperse amphiphilic aminoglucoside–cyclodextrin conjugates depend on the amino disposition at the glycationic head.

Graphical abstract: Cyclodextrin-scaffolded amphiphilic aminoglucoside clusters: self-assembling and gene delivery capabilities
Paper

A releasable disulfide carbonate linker for polyethyleneimine (PEI)-based gene vectors

In the present research study, we used a releasable disulfide carbonate linker to construct polyethyleneimine-based gene vectors with regulated DNA release.

Graphical abstract: A releasable disulfide carbonate linker for polyethyleneimine (PEI)-based gene vectors
Open Access Paper

Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles

Small-sized dendritic phosphonic acids are ideal coatings for iron oxide nanoparticles to be used in vivo.

Graphical abstract: Efficient synthesis of small-sized phosphonated dendrons: potential organic coatings of iron oxide nanoparticles
Paper

Nucleolipids as building blocks for the synthesis of 99mTc-labeled nanoparticles functionalized with folic acid

Nucleoside-lipids are efficient bio-inspired amphiphiles for the construction of nanoparticles for image-guided therapy applications.

Graphical abstract: Nucleolipids as building blocks for the synthesis of 99mTc-labeled nanoparticles functionalized with folic acid
Paper

The impact of two –GlyProGly– motifs on formation of di-copper complexes by His4-cyclopeptides

The interactions of copper(II) ions with the macrocyclic peptide, c(HKHGPG)2, were investigated in aqueous solution as a function of pH by potentiometric titration, spectroscopic (UV-Vis, CD, and EPR) and mass spectrometry (ESI-MS) measurements.

Graphical abstract: The impact of two –GlyProGly– motifs on formation of di-copper complexes by His4-cyclopeptides
Paper

Lipidic spherulites as magnetic resonance imaging contrast agents

Paramagnetic spherulites were successfully obtained following 3 grafting strategies of gadolinium chelate. Grafting onto lipid bilayers gave the best relaxivity results.

Graphical abstract: Lipidic spherulites as magnetic resonance imaging contrast agents
18 articles

About this collection

This themed collection, consisting of 7 review articles and 10 original research papers, covers various types of supramolecular systems at the biological interface: lipids, nucleic acids, peptides, DNA and also various hybrid systems and nanoparticles. Some of the contributions are oriented towards gaining deeper insights into a particular system (self-assembly properties, spectroscopy, intermolecular interactions). Other contributions are focused on applications, particularly in medicine (imaging contrast agents, gene delivery and gene silencing systems, drug delivery).

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