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Themed collection Lab on a Chip 2016 Most Downloaded Articles

25 articles
Open Access Frontier

Microfluidic blood plasma separation for medical diagnostics: is it worth it?

This review weights the advantages and limits of miniaturised blood plasma separation and highlights interesting advances in direct biomarker capture.

Graphical abstract: Microfluidic blood plasma separation for medical diagnostics: is it worth it?
Focus

Flexible sensors for biomedical technology

We provide a selected overview of three types of flexible sensors that have been recently applied to biomedical and healthcare purposes through direct application on the human skin.

Graphical abstract: Flexible sensors for biomedical technology
From the themed collection: Lab on a Chip Recent Focus Articles
Critical Review

A review of digital microfluidics as portable platforms for lab-on a-chip applications

This review evaluates the possibility of developing portable digital microfluidic platforms for lab-on-a-chip applications.

Graphical abstract: A review of digital microfluidics as portable platforms for lab-on a-chip applications
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Droplet microfluidics for microbiology: techniques, applications and challenges

Droplet microfluidics has rapidly emerged as one of the key technologies opening up new experimental possibilities in microbiology.

Graphical abstract: Droplet microfluidics for microbiology: techniques, applications and challenges
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

3D-printed fluidic networks as vasculature for engineered tissue

Fabrication of vascular networks within engineered tissue remains one of the greatest challenges facing the fields of biomaterials and tissue engineering.

Graphical abstract: 3D-printed fluidic networks as vasculature for engineered tissue
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

3D printed microfluidic devices: enablers and barriers

3D printing has the potential to significantly change the field of microfluidics.

Graphical abstract: 3D printed microfluidic devices: enablers and barriers
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

The upcoming 3D-printing revolution in microfluidics

A comprehensive exploration of the state-of-the-art and a critical outlook on the advantages, barriers and potential of 3D-printing in microfluidics.

Graphical abstract: The upcoming 3D-printing revolution in microfluidics
From the themed collection: Lab on a Chip Recent Review Articles
Open Access Critical Review

Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics

This review focuses on developments in the field of droplet microfluidics in the context of drug discovery, genomics and transcriptomics.

Graphical abstract: Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Distance-based microfluidic quantitative detection methods for point-of-care testing

Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings.

Graphical abstract: Distance-based microfluidic quantitative detection methods for point-of-care testing
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Novel developments in mobile sensing based on the integration of microfluidic devices and smartphones

We review novel mobile sensing applications based on the integration of microfluidic devices and smartphones (MS2).

Graphical abstract: Novel developments in mobile sensing based on the integration of microfluidic devices and smartphones
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Microfluidics and microbial engineering

This review highlights the recent development and future opportunities in the interdisciplinary field, integrating microfluidic technology and microbial engineering.

Graphical abstract: Microfluidics and microbial engineering
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Single cells in confined volumes: microchambers and microdroplets

Microfluidic devices capable of manipulating and guiding small fluid volumes open new methodical approaches in the fields of biology, pharmacy, and medicine.

Graphical abstract: Single cells in confined volumes: microchambers and microdroplets
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Soil-on-a-Chip: microfluidic platforms for environmental organismal studies

A review of the most recent developments in so-called “Soil-on-a-Chip” microfluidic technology for environmental organismal studies, including bacteria, nematodes, fungi and plants, as well as inter-organismal interactions.

Graphical abstract: Soil-on-a-Chip: microfluidic platforms for environmental organismal studies
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Fundamentals and applications of inertial microfluidics: a review

We provide a comprehensive review describing the fundamental mechanisms of inertial microfluidics, structure design and applications in biology, medicine and industry.

Graphical abstract: Fundamentals and applications of inertial microfluidics: a review
From the themed collection: Lab on a Chip Recent Review Articles
Critical Review

Active droplet generation in microfluidics

This review presents the state of the art of active microfluidic droplet generation concepts.

Graphical abstract: Active droplet generation in microfluidics
Paper

A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)

A 3D printed chip for the production of neuron-containing alginate capsules.

Graphical abstract: A 3D printed microfluidic device for production of functionalized hydrogel microcapsules for culture and differentiation of human Neuronal Stem Cells (hNSC)
Paper

A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples

We present a low-cost, disposable, and fully-integrated paperfluidic molecular diagnostic chip for sample-to-result functionality at the point-of-care.

Graphical abstract: A fully integrated paperfluidic molecular diagnostic chip for the extraction, amplification, and detection of nucleic acids from clinical samples
Paper

3D printed microfluidic circuitry via multijet-based additive manufacturing

We present a fundamental class of 3D printed microfluidic circuit components and integrated systems constructed using multijet modelling-based approaches.

Graphical abstract: 3D printed microfluidic circuitry via multijet-based additive manufacturing
Paper

An integrated paper-based sample-to-answer biosensor for nucleic acid testing at the point of care

An integrated paper-based sample-to-answer biosensor is proposed, which enables simple paper-based nucleic acid extraction, amplification and detection for point-of-care testing.

Graphical abstract: An integrated paper-based sample-to-answer biosensor for nucleic acid testing at the point of care
Paper

Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues

The beating heart-on-a-chip (i) generates 3D cardiac constructs with well-defined geometries from cell-laden hydrogel prepolymers, (ii) provides uniaxial cyclic mechanical stimulation, (iii) allows efficient delivery of drugs and chemicals.

Graphical abstract: Beating heart on a chip: a novel microfluidic platform to generate functional 3D cardiac microtissues
Open Access Paper

Handheld real-time PCR device

World's smallest, fully autonomous, handheld real-time PCR was shown in this contribution. The device can quickly process up to four samples at a time with detection capability of a single DNA copy. The fully integrated system includes all required electronics for fluorescence measurement, data viewing (LCD display) and processing, and is ideal for use in small clinics and point-of-care applications.

Graphical abstract: Handheld real-time PCR device
Open Access Paper

A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis

Tumor-derived circulating exosomes, enriched with a group of tumor antigens, have been recognized as a promising biomarker source for cancer diagnosis via a less invasive procedure.

Graphical abstract: A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis
Open Access Paper

Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays

3D printing enables the rapid and cost-efficient manufacturing of bespoke, complex prototypes. We show that biocompatibility needs to be considered carefully and provide a specific assay to that effect.

Graphical abstract: Assessment of biocompatibility of 3D printed photopolymers using zebrafish embryo toxicity assays
Open Access Paper

LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus

Sample supply remains the only manual handling step for pathogen detection at the point-of-care.

Graphical abstract: LabDisk with complete reagent prestorage for sample-to-answer nucleic acid based detection of respiratory pathogens verified with influenza A H3N2 virus
Open Access Paper

Digital droplet PCR on disk

An integrated digital droplet PCR system is presented that enables droplet generation, PCR amplification, and readout within a single reaction chamber on a centrifugal microfluidic LabDisk.

Graphical abstract: Digital droplet PCR on disk
25 articles

About this collection

This web collection features the top 25 most downloaded articles published in Lab on a Chip in 2016. Congratulations to all of the authors whose articles have been featured!

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