Jump to main content
Jump to site search

Issue 7, 2016
Previous Article Next Article

Distance-based microfluidic quantitative detection methods for point-of-care testing

Author affiliations

Abstract

Equipment-free devices with quantitative readout are of great significance to point-of-care testing (POCT), which provides real-time readout to users and is especially important in low-resource settings. Among various equipment-free approaches, distance-based visual quantitative detection methods rely on reading the visual signal length for corresponding target concentrations, thus eliminating the need for sophisticated instruments. The distance-based methods are low-cost, user-friendly and can be integrated into portable analytical devices. Moreover, such methods enable quantitative detection of various targets by the naked eye. In this review, we first introduce the concept and history of distance-based visual quantitative detection methods. Then, we summarize the main methods for translation of molecular signals to distance-based readout and discuss different microfluidic platforms (glass, PDMS, paper and thread) in terms of applications in biomedical diagnostics, food safety monitoring, and environmental analysis. Finally, the potential and future perspectives are discussed.

Graphical abstract: Distance-based microfluidic quantitative detection methods for point-of-care testing

Back to tab navigation

Publication details

The article was received on 23 Dec 2015, accepted on 18 Feb 2016 and first published on 18 Feb 2016


Article type: Critical Review
DOI: 10.1039/C5LC01562F
Citation: Lab Chip, 2016,16, 1139-1151
  •   Request permissions

    Distance-based microfluidic quantitative detection methods for point-of-care testing

    T. Tian, J. Li, Y. Song, L. Zhou, Z. Zhu and C. J. Yang, Lab Chip, 2016, 16, 1139
    DOI: 10.1039/C5LC01562F

Search articles by author

Spotlight

Advertisements