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Themed collection Lab on a Chip Recent HOT Articles

35 items
Communication

Cell-free extract based optimization of biomolecular circuits with droplet microfluidics

We combine cell-free protein expression systems with droplet microfluidics to enable ultrahigh-throughput parameter space exploration of synthetic biocircuits.

Graphical abstract: Cell-free extract based optimization of biomolecular circuits with droplet microfluidics
From the themed collection: Lab on a Chip Recent HOT Articles
Communication

Frequency tuning allows flow direction control in microfluidic networks with passive features

A bidirectional pump created by rectifying oscillating flow driven at engineered fluidic series and parallel resonance frequencies.

Graphical abstract: Frequency tuning allows flow direction control in microfluidic networks with passive features
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Multiparameter cell-tracking intrinsic cytometry for single-cell characterization

We introduce a multiparameter intrinsic cytometry approach for single-cell characterization that combines ≥2 label-free measurement techniques onto the same platform.

Graphical abstract: Multiparameter cell-tracking intrinsic cytometry for single-cell characterization
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering

We present an injection molded lab-on-a-disc enabling quantification of bacterial metabolites in E. coli supernatant.

Graphical abstract: Injection molded lab-on-a-disc platform for screening of genetically modified E. coli using liquid–liquid extraction and surface enhanced Raman scattering
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Engineering reaction–diffusion networks with properties of neural tissue

The application of soft lithography to create reaction–diffusion networks capable of generating spatiotemporal patterns analogous to biological central pattern generators.

Graphical abstract: Engineering reaction–diffusion networks with properties of neural tissue
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range

Fluorescence from four emission points is collimated by four lenses, split into four-color fluxes by four dichroic mirrors, and directly input into the image sensor.

Graphical abstract: An ultra-small, multi-point, and multi-color photo-detection system with high sensitivity and high dynamic range
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing

An asymmetric nanofluidic grating is shown to enable simple, robust, and fully differential measurements of refractive index or of surface-adsorbed layers of biomolecules through interferometry.

Graphical abstract: Asymmetric nanofluidic grating detector for differential refractive index measurement and biosensing
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta

Stomatal function can be used effectively to monitor plant hydraulics, photosensitivity, and gas exchange.

Graphical abstract: Persistent drought monitoring using a microfluidic-printed electro-mechanical sensor of stomata in planta
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Optofluidic marine phosphate detection with enhanced absorption using a Fabry–Pérot resonator

An optofluidic phosphate analysis chip combined with a resonator has been created with enhanced absorption and real-time monitoring. It overcomes the obstacles of traditional methods with macroscale absorption cells, and low representative and time-sensitive detection results.

Graphical abstract: Optofluidic marine phosphate detection with enhanced absorption using a Fabry–Pérot resonator
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump

A novel magnetically-driven peristaltic pump can be used to drive cyclic on-chip flow for small volume (50 μL) diafiltration.

Graphical abstract: Microfluidic diafiltration-on-chip using an integrated magnetic peristaltic micropump
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules

A chip design inspired by the “Snakes-and-Ladders” boardgame was used to deposit a bilayer of polyelectrolytes onto magnetic droplets within 30 seconds.

Graphical abstract: On-chip polyelectrolyte coating onto magnetic droplets – towards continuous flow assembly of drug delivery capsules
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Reproducible fiber optofluidic laser for disposable and array applications

This paper describes a low-cost fiber optofluidic laser for disposable and array applications using a microstructured optical fiber.

Graphical abstract: Reproducible fiber optofluidic laser for disposable and array applications
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis

We have developed a microchip platform that combines fast, magnetic micropore based negative selection (>10 mL h−1) with rapid on-chip in situ RNA profiling.

Graphical abstract: A magnetic micropore chip for rapid (<1 hour) unbiased circulating tumor cell isolation and in situ RNA analysis
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles

A microfluidic co-flow of Newtonian (water or PBS) and viscoelastic fluids (PEO) is presented for the size-dependent separation of microparticles.

Graphical abstract: Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels

We demonstrate that 3D printing can consistently fabricate truly microfluidic features (18 μm × 20 μm cross sectional area) by creating a custom 3D printer and a low-cost custom resin.

Graphical abstract: Custom 3D printer and resin for 18 μm × 20 μm microfluidic flow channels
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices

A variety of therapeutic and/or diagnostic nanoparticles (NPs), or nanomedicines, have been formulated for improved drug delivery and imaging applications.

Graphical abstract: Robust manufacturing of lipid-polymer nanoparticles through feedback control of parallelized swirling microvortices
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Studying blood clotting in stereolithography 3D-printed microfluidic chips with endothelialised vascular structures.

Graphical abstract: Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics

This work presents an on-chip valve-based microfluidic automation module, capable of performing the complex fluid handling required for photonic biosensors.

Graphical abstract: An automated optofluidic biosensor platform combining interferometric sensors and injection moulded microfluidics
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Multicomponent diffusion coefficients from microfluidics using Raman microspectroscopy

Microfluidic measurement of multicomponent diffusion coefficients using minimal number of experiments with high accuracy in short time.

Graphical abstract: Multicomponent diffusion coefficients from microfluidics using Raman microspectroscopy
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

On-chip cell sorting by high-speed local-flow control using dual membrane pumps

We achieved high-throughput on-chip sorting of large cells by using on-chip dual membrane pumps integrated with a high-rigidity microfluidic chip. In the case of Euglena gracilis sorting, the throughput was 23 kHz with 92.8% success rate, 95.8% purity, and 90.8% cell viability.

Graphical abstract: On-chip cell sorting by high-speed local-flow control using dual membrane pumps
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs

3D printed conformal microfluidics provide a novel approach for isolation and profiling of biomarkers from whole organs.

Graphical abstract: 3D printed conformal microfluidics for isolation and profiling of biomarkers from whole organs
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands

We introduce a skin-mounted microfluidic device for measuring the secretory pressure of sweat glands at the surface of the skin.

Graphical abstract: Soft, skin-mounted microfluidic systems for measuring secretory fluidic pressures generated at the surface of the skin by eccrine sweat glands
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Size-tunable microvortex capture of rare cells

A wide distribution of cell sizes can be selectively captured by tuning the flow rate in a micro-vortex flow.

Graphical abstract: Size-tunable microvortex capture of rare cells
From the themed collection: Personalised Medicine: Liquid Biopsy
Paper

Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy

Machine-learning-assisted identification of platelet aggregation in human blood with label-free images.

Graphical abstract: Label-free detection of aggregated platelets in blood by machine-learning-aided optofluidic time-stretch microscopy
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion

A new microfluidic-integrated nanoplasmonic biosensor for the study of cell signaling in a label-free and real-time manner.

Graphical abstract: Plasmonic nanohole array biosensor for label-free and real-time analysis of live cell secretion
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter

A novel microfluidic design enables repeated phase transitions in a single sample by surrounding fluid exchange and microrheological characterization.

Graphical abstract: Using μ2rheology to quantify rheological properties during repeated reversible phase transitions of soft matter
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Integrated pretreatment and desalination by electrocoagulation (EC)–ion concentration polarization (ICP) hybrid

We integrated desalination and particle removal technologies into a single electrochemical system and demonstrated its operation on a microfluidic platform.

Graphical abstract: Integrated pretreatment and desalination by electrocoagulation (EC)–ion concentration polarization (ICP) hybrid
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation

We introduce a robust microfluidic platform for production of relatively homogenous microdroplets at generation frequency of up to 3.1 MHz, about three orders of magnitude higher than the production rate of a conventional microfluidic dropmaker.

Graphical abstract: A versatile microfluidic device for high throughput production of microparticles and cell microencapsulation
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Paper

On-chip enzymatic microbiofuel cell-powered integrated circuits

A CMOS based digital circuit that is powered by an integrated on-chip enzymatic microbiofuelcell.

Graphical abstract: On-chip enzymatic microbiofuel cell-powered integrated circuits
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice

A biomimetic glomerulus-on-a-chip microdevice was created to recapitulate a disease model of diabetic nephropathy.

Graphical abstract: A disease model of diabetic nephropathy in a glomerulus-on-a-chip microdevice
From the themed collection: Organ-, body- and disease-on-a-chip systems
Open Access Paper

Device and programming abstractions for spatiotemporal control of active micro-particle swarms

We present a hardware setup and a set of executable commands for spatiotemporal programming and interactive control of a swarm of self-propelled microscopic agents (Euglena gracilis) inside a microfluidic chip.

Graphical abstract: Device and programming abstractions for spatiotemporal control of active micro-particle swarms
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Dielectrowetting manipulation for digital microfluidics: creating, transporting, splitting, and merging of droplets

Fundamental and critical unit operations (creating, transporting, splitting and merging of droplets) for digital (droplet-based) microfluidic circuits have been established using dielectrowetting.

Graphical abstract: Dielectrowetting manipulation for digital microfluidics: creating, transporting, splitting, and merging of droplets
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets

Pancreatic islets on a chip platform.

Graphical abstract: Resealable, optically accessible, PDMS-free fluidic platform for ex vivo interrogation of pancreatic islets
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus

A flow cytometry technique featuring the all-optical measurement of nuclear mechanical properties is developed by integrating Brillouin spectroscopy with microfluidics.

Graphical abstract: Brillouin flow cytometry for label-free mechanical phenotyping of the nucleus
From the themed collection: Lab on a Chip Recent HOT Articles
35 items

About this collection

Here is a collection of recent Lab on a Chip articles which have been classified as ‘HOT articles’ due to receiving particularly high scores at peer review.

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