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Themed collection 2016 Lab on a Chip Emerging Investigators

21 articles
Editorial

Emerging Investigators 2016: discovery science meets technology

Guest editors Charles M. Schroeder, Sarah Köster and Yanyi Huang introduce the 2016 Emerging Investigators themed issue of Lab on a Chip.

Graphical abstract: Emerging Investigators 2016: discovery science meets technology
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Profile

Contributors to Emerging Investigators 2016

Contributors to the Lab on a Chip Emerging Investigators 2016 themed issue.

Graphical abstract: Contributors to Emerging Investigators 2016
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Communication

AC electric field induced droplet deformation in a microfluidic T-junction

We present a novel method for the deformation of droplets in a microfluidic T-junction using an AC electric field.

Graphical abstract: AC electric field induced droplet deformation in a microfluidic T-junction
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

High efficiency hydrodynamic bacterial electrotransformation

Synthetic biology holds great potential for addressing pressing challenges for mankind and our planet.

Graphical abstract: High efficiency hydrodynamic bacterial electrotransformation
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

One-step immunoassay of C-reactive protein using droplet microfluidics

A wash-free droplet microfluidic platform for C-reactive-protein-based diagnosis with reduced assay time and enhanced sensitivity.

Graphical abstract: One-step immunoassay of C-reactive protein using droplet microfluidics
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

The impact of probe size on measurements of diffusion in active microrheology

A framework to study the influence of polydispersity on flow-induced diffusion in active microrheology is presented. It is found that diffusive behavior is set entirely and dually by the proximity with which two particles can approach one another, and by the extent to which this minimum approach distance is occupied by the hydrodynamic size of the forced particle.

Graphical abstract: The impact of probe size on measurements of diffusion in active microrheology
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Cell-on-hydrogel platform made of agar and alginate for rapid, low-cost, multidimensional test of antimicrobial susceptibility

Incorporating microfluidics into plate culture, this inexpensive platform generates stable 2D gradients of drugs for testing their synergistic effects. Culturing sample on top of the device eliminates the concern of shear flow, enables convenient collection of cells, and allows quick test based on single-cell image analysis.

Graphical abstract: Cell-on-hydrogel platform made of agar and alginate for rapid, low-cost, multidimensional test of antimicrobial susceptibility
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Open Access Paper

Delivery of minimally dispersed liquid interfaces for sequential surface chemistry

Rapid liquid switching on a microfluidic probe enables localized multi-step surface reactions.

Graphical abstract: Delivery of minimally dispersed liquid interfaces for sequential surface chemistry
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

A microfluidic device integrating dual CMOS polysilicon nanowire sensors for on-chip whole blood processing and simultaneous detection of multiple analytes

We report a microfluidic device integrating dual CMOS polysilicon nanowire sensors (MINS) for on-chip whole blood processing and simultaneous detection of Hb and HbA1c.

Graphical abstract: A microfluidic device integrating dual CMOS polysilicon nanowire sensors for on-chip whole blood processing and simultaneous detection of multiple analytes
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Portable visual quantitative detection of aflatoxin B1 using a target-responsive hydrogel and a distance-readout microfluidic chip

A distance-readout microfluidic chip was combined with an AFB1-responsive hydrogel for rapid, portable, selective, and quantitative detection of AFB1 in real samples.

Graphical abstract: Portable visual quantitative detection of aflatoxin B1 using a target-responsive hydrogel and a distance-readout microfluidic chip
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

A microfluidic flow focusing platform to screen the evolution of crude oil–brine interfacial elasticity

Multiphase fluid flow dynamics dominate processes used to recover the majority of hydrocarbon resources produced by global energy industries.

Graphical abstract: A microfluidic flow focusing platform to screen the evolution of crude oil–brine interfacial elasticity
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Open Access Paper

Graphene-based microfluidics for serial crystallography

A robust strategy for the incorporation of graphene films as a diffusion barrier in ultra-thin X-ray compatible microfluidic devices.

Graphical abstract: Graphene-based microfluidics for serial crystallography
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

A microphysiological model of the human placental barrier

We present a microengineered cell culture device designed to mimic the maternal–fetal interface in the human placenta.

Graphical abstract: A microphysiological model of the human placental barrier
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Confinement and viscosity ratio effect on droplet break-up in a concentrated emulsion flowing through a narrow constriction

This paper describes the dimensionless groups that determine the break-up probability of droplets in a concentrated emulsion during its flow in a tapered microchannel consisting of a narrow constriction.

Graphical abstract: Confinement and viscosity ratio effect on droplet break-up in a concentrated emulsion flowing through a narrow constriction
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Magnetic Nickel iron Electroformed Trap (MagNET): a master/replica fabrication strategy for ultra-high throughput (>100 mL h−1) immunomagnetic sorting

We present a new approach to microfabricate micromagnetic sorting devices that can achieve highly specific cell separation at a throughput (ϕ > 150 mL h−1) 100× greater than conventional microfluidics.

Graphical abstract: Magnetic Nickel iron Electroformed Trap (MagNET): a master/replica fabrication strategy for ultra-high throughput (>100 mL h−1) immunomagnetic sorting
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

High-throughput superhydrophobic microwell arrays for investigating multifactorial stem cell niches

A superhydrophobic microwell array chip (SMARchip) was developed for high-throughput screening.

Graphical abstract: High-throughput superhydrophobic microwell arrays for investigating multifactorial stem cell niches
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Non-spherical particle generation from 4D optofluidic fabrication

We present a novel method for creating asymmetric three-dimensional particles termed 4D optofluidic fabrication utilizing inertial and gravity-induced flow shaping and UV polymerization.

Graphical abstract: Non-spherical particle generation from 4D optofluidic fabrication
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Open Access Paper

Arrayed water-in-oil droplet bilayers for membrane transport analysis

We developed an arrayed water-in-oil droplet bilayer system for highly sensitive and quantitative membrane transport analysis.

Graphical abstract: Arrayed water-in-oil droplet bilayers for membrane transport analysis
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Open Access Paper

Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating

A GO-induced 3D nanoporous PDA surface coating was developed to substantially improve the sensitivity of immuno-detection of circulating exosomes directly in clinical samples.

Graphical abstract: Ultrasensitive microfluidic analysis of circulating exosomes using a nanostructured graphene oxide/polydopamine coating
Paper

Optofluidic restricted imaging, spectroscopy and counting of nanoparticles by evanescent wave using immiscible liquids

An integrated optofluidic chip for restricted imaging, spectroscopy and counting of nanoparticles using the evanescent wave of total internal reflection at the interface of immiscible flows.

Graphical abstract: Optofluidic restricted imaging, spectroscopy and counting of nanoparticles by evanescent wave using immiscible liquids
From the themed collection: 2016 Lab on a Chip Emerging Investigators
Paper

Onset of particle trapping and release via acoustic bubbles

We quantitatively analyze the secondary radiation force of an acoustic bubble for particle trapping and release in a flow.

Graphical abstract: Onset of particle trapping and release via acoustic bubbles
From the themed collection: 2016 Lab on a Chip Emerging Investigators
21 articles

About this collection

Lab on a Chip is committed to supporting early career scientists, and it is because of this that we are both proud and very pleased to introduce the 2016 edition of our Emerging Investigators issue, which celebrates the most promising and brightest amongst early career miniaturisation scientists around the world. The fourth Emerging Instigators issue was guest edited by Yanyi Huang, Sarah Köster and Charles Schroeder who worked hard to create this issue and ensure that its content was of the highest quality. Please read the articles below to see how our Emerging Investigators are contributing to the world of miniaturisation.

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