Issue 13, 2019

Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF3-substituted ketones

Abstract

Electrochemical oxidative radical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols were developed in this study. This approach is environmentally benign and uses the shelf-stable Langlois reagent as a trifluoromethyl radical precursor and electrons as the oxidizing reagents. The present protocol offers a facile route to prepare β-trifluoromethylated ketone derivatives.

Graphical abstract: Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF3-substituted ketones

Supplementary files

Article information

Article type
Communication
Submitted
15 Feb 2019
Accepted
07 Mas 2019
First published
07 Mas 2019

Org. Biomol. Chem., 2019,17, 3319-3323

Electrochemical trifluoromethylation/semipinacol rearrangement sequences of alkenyl alcohols: synthesis of β-CF3-substituted ketones

H. I. Jung, Y. Kim and D. Y. Kim, Org. Biomol. Chem., 2019, 17, 3319 DOI: 10.1039/C9OB00373H

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