Issue 13, 2019

A visible-light-induced cascade reaction of etherification/C–C cyclization: efficient synthesis of dibenzo[b,d]oxepin-7(6H)-ones

Abstract

A visible-light-induced palladium-catalyzed cascade reaction was developed by etherification/C–C coupling cyclization of α-bromoacetophenones with phenols. A series of dibenzo[b,d]oxepin-7(6H)-one derivatives were efficiently synthesized by using this method in good yields. Furthermore, this method was applied to the synthesis of protosappanin A. The protocol has advantages such as simple reaction conditions, wide range of substrates and high reaction efficiency.

Graphical abstract: A visible-light-induced cascade reaction of etherification/C–C cyclization: efficient synthesis of dibenzo[b,d]oxepin-7(6H)-ones

Supplementary files

Article information

Article type
Communication
Submitted
31 Jan 2019
Accepted
11 Mar 2019
First published
11 Mar 2019

Org. Biomol. Chem., 2019,17, 3324-3327

A visible-light-induced cascade reaction of etherification/C–C cyclization: efficient synthesis of dibenzo[b,d]oxepin-7(6H)-ones

W. Fu, A. Yu, H. Jiang, M. Zuo, H. Wu, Z. Yang, Q. An, Z. Sun and W. Chu, Org. Biomol. Chem., 2019, 17, 3324 DOI: 10.1039/C9OB00247B

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