Themed collection Celebrating 10 years of Chemical Science
![](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/Ajax-GA-Loader.gif)
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Celebrating 10 years of Chemical Science
Welcome to the first of our special anniversary issues planned for this year, marking 10 years since Chemical Science published its first issue, back in July 2010.
Chem. Sci., 2020,11, 6351-6351
https://doi.org/10.1039/D0SC90127J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Confined space design by nanoparticle self-assembly
This perspective gives an outlook on the design of interparticle confined nanocavities in self-assembled NP systems and their functional relevance.
Chem. Sci., 2021,12, 1632-1646
https://doi.org/10.1039/D0SC05697A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Defunctionalisation catalysed by boron Lewis acids
The combination of boron Lewis acid catalysts and hydride sources enables the cleavage of various carbon–heteroatom bonds.
Chem. Sci., 2020,11, 12604-12615
https://doi.org/10.1039/D0SC03712E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
From CO2 activation to catalytic reduction: a metal-free approach
This review article documents the key developments in the metal-free catalytic reduction of CO2 into various energy intensive chemicals and fuels, and reductive functionalization of CO2 for the formation of new C–N bonds.
Chem. Sci., 2020,11, 10571-10593
https://doi.org/10.1039/D0SC03528A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Grafted semiconducting polymer amphiphiles for multimodal optical imaging and combination phototherapy
This review summarizes the applications of grafted semiconducting polymer amphiphiles (SPAs) as multimodal optical nanoagents for cancer imaging and combination phototherapy.
Chem. Sci., 2020,11, 10553-10570
https://doi.org/10.1039/D0SC01721C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
The evolution of molecular machines through interfacial nanoarchitectonics: from toys to tools
Molecular machines can be made more useful with interfacial nanoarchitectonics.
Chem. Sci., 2020,11, 10594-10604
https://doi.org/10.1039/D0SC03164J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
The endeavor of vibration-induced emission (VIE) for dynamic emissions
The emission response for vibration-induced emission luminogens is highly sensitive to the encountered steric hindrance during the planarization process such that a tiny structural variation could induce an obvious change in fluorescence.
Chem. Sci., 2020,11, 7525-7537
https://doi.org/10.1039/D0SC01591A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Current advances in tin cluster chemistry
Clusters containing tin atoms show a huge variety of molecular structures, chemical as well as physical properties.
Chem. Sci., 2020,11, 16-26
https://doi.org/10.1039/C9SC04363B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Development and application of ubiquitin-based chemical probes
This article reviews the design, synthesis, and application of different classes of Ub-based chemical probes.
Chem. Sci., 2020,11, 12633-12646
https://doi.org/10.1039/D0SC03295F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy
This minireview introduces Pd-catalyzed direct asymmetric C–H functionalization reactions using a directing group strategy.
Chem. Sci., 2020,11, 12616-12632
https://doi.org/10.1039/D0SC03052J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Light opens a new window for N-heterocyclic carbene catalysis
This minireview summarized the recent advances on the photoinduced, NHC-catalyzed organic reactions according to the function of visible light.
Chem. Sci., 2020,11, 10605-10613
https://doi.org/10.1039/D0SC03595E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Electrodeposition of (hydro)oxides for an oxygen evolution electrode
This minireview looks at recent electrodeposition strategies for metal (hydro)oxide design and water oxidation applications, unveiling the unique properties and underlying principles of electrodeposited metal (hydro)oxides in the OER.
Chem. Sci., 2020,11, 10614-10625
https://doi.org/10.1039/D0SC01532F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Synthesis of azetidines by aza Paternò–Büchi reactions
This review discusses the current scope and limitations of the [2 + 2] photocycloaddition reaction between an imine and an alkene component, the aza Paternò–Büchi reaction, and highlights recent improvements within this area of research.
Chem. Sci., 2020,11, 7553-7561
https://doi.org/10.1039/D0SC01017K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Retrosynthetic strategies and their impact on synthesis of arcutane natural products
Decisions, decisions, decisions: the interplay between different retrosynthetic strategies in the synthesis of the highly bridged, polycyclic arcutane natural products.
Chem. Sci., 2020,11, 7538-7552
https://doi.org/10.1039/D0SC01441A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Microfluidic systems for rapid antibiotic susceptibility tests (ASTs) at the single-cell level
Recent developments of microfluidics-based antibiotic susceptibility tests (ASTs) at the single-cell or single-molecule level are summarized for guiding antibiotic treatment.
Chem. Sci., 2020,11, 6352-6361
https://doi.org/10.1039/D0SC01353F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
From reactive carbenes to chiral polyether macrocycles in two steps – synthesis and applications made easy?
Chiral polyether macrocycles are versatile molecules.
Chem. Sci., 2020,11, 6362-6369
https://doi.org/10.1039/D0SC01011A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Mechanochemical generation of acid-degradable poly(enol ether)s
A mechanically responsive polymer system that is hydrolytically stable without stress, but unmasks enol ether backbone linkages under force to allow facile hydrolytic degradation.
Chem. Sci., 2021,12, 4389-4394
https://doi.org/10.1039/D1SC00001B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Light-control of cap methylation and mRNA translation via genetic code expansion of Ecm1
A tyrosine in the active site of the 5′ cap methyltransferase Ecm1 was photocaged. Translation of mRNA could be triggered by light in eukaryotic cell lysate.
Chem. Sci., 2021,12, 4383-4388
https://doi.org/10.1039/D1SC00159K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Soluble, crystalline, and thermally stable alkali CO2− and carbonite (CO22−) clusters supported by cyclic(alkyl)(amino) carbenes
The direct chemical reduction of CAACCO2 adducts by alkali metals to yield multinuclear clusters is reported. The mono- and dianions of CO2 have been studied for decades and are fundamentally important oxycarbanions and critical species in CO2 fixation chemistry.
Chem. Sci., 2021,12, 3544-3550
https://doi.org/10.1039/D0SC06851A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Shifting the scaling relations of single-atom catalysts for facile methane activation by tuning the coordination number
The scaling relationship of methane activation via a radical-like transition state shifts toward a more reactive region with decreasing coordination number of the active sites.
Chem. Sci., 2021,12, 3551-3557
https://doi.org/10.1039/D0SC05632D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Multicolor polymeric carbon dots: synthesis, separation and polyamide-supported molecular fluorescence
Understanding the origin and sensitivity of carbon dot emission will improve their utility in various applications.
Chem. Sci., 2021,12, 2441-2455
https://doi.org/10.1039/D0SC05743F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Impact of sphingosine and acetylsphingosines on the aggregation and toxicity of metal-free and metal-treated amyloid-β
The reactivity of sphingosine and acetylsphingosines towards both metal-free and metal-treated amyloid-β is demonstrated showing a correlation of their micellization properties.
Chem. Sci., 2021,12, 2456-2466
https://doi.org/10.1039/D0SC04366D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A dual-fluorophore sensor approach for ratiometric fluorescence imaging of potassium in living cells
We report a dual-fluorophore approach for ratiometric fluorescent imaging of K+ levels in live cells. Intracellular esterases cleave RPS-1 to detach the K+-responsive fluorophore (PS525) from its internal standard (Coumarin 343).
Chem. Sci., 2021,12, 1720-1729
https://doi.org/10.1039/D0SC03844J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Dynamic spatial and structural organization in artificial cells regulates signal processing by protein scaffolding
Engineered artificial cells respond to environmental cues through a pre-programmed enzymatic machinery that induces spatio-structural organization and activation of effector proteins at the lipid membrane.
Chem. Sci., 2020,11, 12829-12834
https://doi.org/10.1039/D0SC03933K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Sustainable and rapid preparation of nanosized Fe/Ni-pentlandite particles by mechanochemistry
A sustainable and rapid mechanochemical method for the preparation of bimetallic nanosized pentlandite particles as cathode material is developed and tested within zero-gap PEM cells.
Chem. Sci., 2020,11, 12835-12842
https://doi.org/10.1039/D0SC04525J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Highly conducting Wurster-type twisted covalent organic frameworks
Covalent organic frameworks define a versatile structural paradigm combining various attractive properties. The impact of different dopants on the conductivity of imine-linked 2D COFs featuring a redox-active Wurster-type motif was studied.
Chem. Sci., 2020,11, 12843-12853
https://doi.org/10.1039/D0SC03909H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A click-flipped enzyme substrate boosts the performance of the diagnostic screening for Hunter syndrome
Click-triggered flip of the conformation of a sulfated iduronyl azide afforded a superior enzyme substrate to screen for Hunter syndrome.
Chem. Sci., 2020,11, 12671-12676
https://doi.org/10.1039/D0SC04696E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Hexa-peri-benzocoronene with two extra K-regions in an ortho-configuration
We reported the synthesis of hexa-peri-benzocoronene (HBC) with two extra K-regions adopting an ortho-configuration. The systematical study provides deep insights about the effect of zigzag edge on the π-conjugated pathway and molecular design.
Chem. Sci., 2020,11, 12816-12821
https://doi.org/10.1039/D0SC04649C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Fucosylated ubiquitin and orthogonally glycosylated mutant A28C: conceptually new ligands for Burkholderia ambifaria lectin (BambL)
Metal free click reactions used to glycosylate ubiquitin and its mutant A28C afforded two protein scaffolds with high affinity for Burkholderia ambifaria lectin (BambL).
Chem. Sci., 2020,11, 12662-12670
https://doi.org/10.1039/D0SC03741A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry
Aminoalkyl radicals can be used as both initiators and chain-carriers for the conversion of aryl halides into the corresponding radicals. This approach by-passes the requirement for strongly reducing photocatalysts.
Chem. Sci., 2020,11, 12822-12828
https://doi.org/10.1039/D0SC04387G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
H2/CO2 separations in multicomponent metal-adeninate MOFs with multiple chemically distinct pore environments
Tailorable multicomponent MOFs and MOF membranes for efficient H2/CO2 separation.
Chem. Sci., 2020,11, 12807-12815
https://doi.org/10.1039/D0SC04979D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo
A near-infrared fluorescence probe for detecting pantetheinase activity has been used for imaging pantetheinase in mice with inflammatory bowel disease.
Chem. Sci., 2020,11, 12802-12806
https://doi.org/10.1039/D0SC04537C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A diketopyrrolopyrrole dye-based dyad on a porous TiO2 photoanode for solar-driven water oxidation
Construction of a water oxidising photoanode with an organic chromophore-catalyst dyad.
Chem. Sci., 2020,11, 12769-12776
https://doi.org/10.1039/D0SC04509H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Prediction of drug metabolites using neural machine translation
The structure of the drug, represented with a SMILES sequence, is being translated into the structures of possible metabolites that can be formed in the human body.
Chem. Sci., 2020,11, 12777-12788
https://doi.org/10.1039/D0SC02639E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Characterization of a putative sensory [FeFe]-hydrogenase provides new insight into the role of the active site architecture
Characterization of a group D putative sensory [FeFe]-hydrogenase reveals how the active site can be tuned to decrease CO inhibition and increase stability of a reduced H-cluster while retaining the ability to catalyze H+/H2 interconversion.
Chem. Sci., 2020,11, 12789-12801
https://doi.org/10.1039/D0SC03319G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
trans-Hydroboration–oxidation products in Δ5-steroids via a hydroboration-retro-hydroboration mechanism
A trans-product is isolated and characterized under traditional hydroboration–oxidation conditions using Δ5-steroids as substrates. Experimental and theoretical studies indicate that the trans-species occurs via a retro-hydroboration mechanism.
Chem. Sci., 2020,11, 12764-12768
https://doi.org/10.1039/D0SC01701A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening
Ultra-high throughput in silico screening identified molecules that bind to α-synuclein fibrils, which were analyzed by photo-crosslinking, structure-activity studies, and radioligand binding to validate this approach for finding imaging probes.
Chem. Sci., 2020,11, 12746-12754
https://doi.org/10.1039/D0SC02159H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Combining free energy calculations with tailored enzyme activity assays to elucidate substrate binding of a phospho-lysine phosphatase
Combining phosphatase activity assays with molecular docking and free energy calculations reveals low promiscuity and substrate binding of intrinsically labile phospho-lysine peptides to the enzyme LHPP.
Chem. Sci., 2020,11, 12655-12661
https://doi.org/10.1039/D0SC03930F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
AIE-based nanoaggregate tracker: high-fidelity visualization of lysosomal movement and drug-escaping processes
Well-formed AIE nanoaggregates with good stability can achieve high-fidelity visualization of lysosomal movement and drug-escaping processes.
Chem. Sci., 2020,11, 12755-12763
https://doi.org/10.1039/D0SC04156D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter
A new mitochondrial uncoupler that forms membrane permeable dimers through interactions of remote acidic and anion receptor groups.
Chem. Sci., 2020,11, 12677-12685
https://doi.org/10.1039/D0SC02777D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
On the electronic structure and hydrogen evolution reaction activity of platinum group metal-based high-entropy-alloy nanoparticles
RuRhPdIrPt high-entropy-alloy nanoparticles with a broad and featureless valence band spectrum show high hydrogen evolution reaction activity.
Chem. Sci., 2020,11, 12731-12736
https://doi.org/10.1039/D0SC02351E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Extraordinary electrochemical stability and extended polaron delocalization of ladder-type polyaniline-analogous polymers
Electrochemical stability and state delocalization critically impact the functions and practical applications of electronically active polymers.
Chem. Sci., 2020,11, 12737-12745
https://doi.org/10.1039/D0SC03348K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
The influences of carbon donor ligands on biomimetic multi-iron complexes for N2 reduction
High-spin diiron alkylidenes give insight into the electronic structure and functional relevance of carbon in the FeMoco active site of nitrogenase.
Chem. Sci., 2020,11, 12710-12720
https://doi.org/10.1039/D0SC03447A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment
Phenol-like group functionalized graphene quantum dots that structurally mimic natural antioxidants are constructed as high-efficacy reactive oxygen species scavengers for acute kidney injury antioxidative therapy.
Chem. Sci., 2020,11, 12721-12730
https://doi.org/10.1039/D0SC03246H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Controlled synthesis of organic two-dimensional nanostructures via reaction-driven, cooperative supramolecular polymerization
We report the kinetically controlled supramolecular polymerization of organic two-dimensional charge-transfer nanostructures via a chemical reaction (imine)-driven approach.
Chem. Sci., 2020,11, 12701-12709
https://doi.org/10.1039/D0SC02670K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A new pentacyclic pyrylium fluorescent probe that responds to pH imbalance during apoptosis
A modified Vilsmeier–Haack reaction resulted in the synthesis of a pyrylium based turn-on fluorescent pH probe. The probe can monitor minute acidification and dynamic pH variation in cells during apoptosis with therapeutic chemo drugs.
Chem. Sci., 2020,11, 12695-12700
https://doi.org/10.1039/D0SC02623A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Accelerated microdroplet synthesis of benzimidazoles by nucleophilic addition to protonated carboxylic acids
We report a metal-free novel route for the accelerated synthesis of benzimidazole and its derivatives in the ambient atmosphere.
Chem. Sci., 2020,11, 12686-12694
https://doi.org/10.1039/D0SC02467H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Total scattering reveals the hidden stacking disorder in a 2D covalent organic framework
With total scattering methods and stacking fault simulations, we observe previously predicted random local layer offsets in a COF, which are typically disguised by the apparent crystallographic symmetry but strongly influence properties.
Chem. Sci., 2020,11, 12647-12654
https://doi.org/10.1039/D0SC03048A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways
To understand factors that determine ring pattern and stereochemistry of thioether cyclization of lanthipeptide natural products, the structures of five prochlorosins (blue) and two enterococcal cytolysins (red) were determined by NMR spectroscopy.
Chem. Sci., 2020,11, 12854-12870
https://doi.org/10.1039/D0SC01651A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Activation chemistry drives the emergence of functionalised protocells
The complexity of the simplest conceivable cell suggests that the chemistry of prebiotic mixtures needs to be explored to understand the intricate network of prebiotic reactions that led to the emergence of life.
Chem. Sci., 2020,11, 10688-10697
https://doi.org/10.1039/D0SC04506C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Triboluminescence of a new family of CuI–NHC complexes in crystalline solid and in amorphous polymer films
Triboluminescent compounds that generate emission of light in response to mechanical stimulus are promising targets in the development of “smart materials” and damage sensors.
Chem. Sci., 2020,11, 10814-10820
https://doi.org/10.1039/D0SC04442C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Redox chemistry and H-atom abstraction reactivity of a terminal zirconium(IV) oxo compound mediated by an appended cobalt(I) center
Bimetallic cooperativity is demonstrated with a Co/Zr complex featuring both nucleophilic Zr(IV) oxo and redox active Co sites.
Chem. Sci., 2020,11, 10729-10736
https://doi.org/10.1039/D0SC04229C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Triple the fun: tris(ferrocenyl)arene-based gold(I) complexes for redox-switchable catalysis
Trinuclear gold(I) complexes of C3-symmetric tris(ferrocenyl)arene-based tris-phosphanes with four accessible oxidation states catalyse the ring-closing isomerisation of N-(2-propyn-1-yl)benzamide with different rates depending on their redox state.
Chem. Sci., 2020,11, 10657-10668
https://doi.org/10.1039/D0SC03604H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Hierarchical nanosheets built from superatomic clusters: properties, exfoliation and single-crystal-to-single-crystal intercalation
Designer inorganic nanoblocks encrypt 2D superatomic crystals with in-plane anisotropy, quasi-chiral domains and rich physicochemical properties.
Chem. Sci., 2020,11, 10744-10751
https://doi.org/10.1039/D0SC03506H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Total synthesis of biseokeaniamides A–C and late-stage electrochemically-enabled peptide analogue synthesis
A late-stage electrochemical decarboxylation enables rapid access to structural analogues of biseokeaniamides A–C, cytotoxic lipopeptide natural products.
Chem. Sci., 2020,11, 10752-10758
https://doi.org/10.1039/D0SC03701J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Rules for the design of aza-glycine stabilized triple-helical collagen peptides
Guidelines for incorporating aza-glycine residues in collagen peptides are presented, detailing their effects on triple-helical thermal stability.
Chem. Sci., 2020,11, 10638-10646
https://doi.org/10.1039/D0SC03003A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Modulation of metal-azolate frameworks for the tunable release of encapsulated glycosaminoglycans
Clinical and pre-clinical GAG-based biotherapeutics were encapsulated within three metal-azolate frameworks (ZIF-8, ZIF-90, and MAF-7). The resulting MOF biocomposites show different loading capacity, biopreservation properties and release profiles.
Chem. Sci., 2020,11, 10835-10843
https://doi.org/10.1039/D0SC01204A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Enthalpic incompatibility between two steric stabilizer blocks provides control over the vesicle size distribution during polymerization-induced self-assembly in aqueous media
SAXS studies confirm that a judicious binary mixture of enthalpically incompatible steric stabilizer blocks enables the synthesis of relatively small, well-defined vesicles via polymerization-induced self-assembly in aqueous media.
Chem. Sci., 2020,11, 10821-10834
https://doi.org/10.1039/D0SC01320J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Chem. Sci., 2020,11, 10626-10630
https://doi.org/10.1039/D0SC02823A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Nanostructured liquid-crystalline Li-ion conductors with high oxidation resistance: molecular design strategy towards safe and high-voltage-operation Li-ion batteries
Ion-conductive liquid-crystalline molecules with high-oxidation resistance, which were designed with density functional theory calculation, improved charge–discharge reactions in Li-ion batteries.
Chem. Sci., 2020,11, 10631-10637
https://doi.org/10.1039/D0SC01646B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Deciphering the origin of million-fold reactivity observed for the open core diiron [HO–FeIII–O–FeIV
O]2+ species towards C–H bond activation: role of spin-states, spin-coupling, and spin-cooperation
Our results unequivocally reveal the importance of spin states, spin coupling and spin cooperation in controlling the reactivity in dinuclear Fe-oxo species.
Chem. Sci., 2020,11, 10669-10687
https://doi.org/10.1039/D0SC02624G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
H/D exchange under mild conditions in arenes and unactivated alkanes with C6D6 and D2O using rigid, electron-rich iridium PCP pincer complexes
The synthesis and characterization of an iridium polyhydride complex (Ir-H4) supported by an electron-rich PCP framework and capable of mild hydrogen/deuterium exchange catalysis is described.
Chem. Sci., 2020,11, 10705-10717
https://doi.org/10.1039/D0SC02694H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Insights into the behavior of nonanoic acid and its conjugate base at the air/water interface through a combined experimental and theoretical approach
The surface partitioning of a medium chain fatty acid and its conjugate base has been investigated through a combined experimental and theoretical approach of the multi-equilibria involved in the bulk phase and at the air/water interface.
Chem. Sci., 2020,11, 10647-10656
https://doi.org/10.1039/D0SC02354J
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Annulative π-extension of BODIPYs made easy via gold(I)-catalyzed cycloisomerization
Here we report gold(I)-catalyzed cycloisomerization as a new powerful synthetic tool for the preparation of π-extended BODIPY derivatives.
Chem. Sci., 2020,11, 10778-10785
https://doi.org/10.1039/D0SC01054E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Carbonization of single polyacrylonitrile chains in coordination nanospaces
Accommodation of polyacrylonitrile in MOFs facilitated and regulated the transformation to ladder polymer in the carbonization process.
Chem. Sci., 2020,11, 10844-10849
https://doi.org/10.1039/D0SC02048F
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Amination of the Gd@C82 endohedral fullerene: tunable substitution effect on quantum coherence behaviors
Amination of the endohedral fullerene Gd@C82 exhibits enhanced quantum phase memory time and tunable substitution effect for quantum information processing.
Chem. Sci., 2020,11, 10737-10743
https://doi.org/10.1039/D0SC02182B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Double annulation of ortho- and peri-C–H bonds of fused (hetero)arenes to unusual oxepino-pyridines
Direct difunctionalization of chemically distinct ortho- and peri-C–H bonds of fused hetero(arenes) is illustrated through an unusual one-pot domino {[4 + 2] & [5 + 2]} double annulation with alkynes for the first time.
Chem. Sci., 2020,11, 10770-10777
https://doi.org/10.1039/D0SC01373K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
Exploiting clock transitions for the chemical design of resilient molecular spin qubits
We employ a python computational tool to compare 3 relevant case studies with increasingly complex ground states: vanadyl complexes, Ho(III) square antiprisms and Ho(III) cubic structures.
Chem. Sci., 2020,11, 10718-10728
https://doi.org/10.1039/D0SC01187H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
A reconstructed porous copper surface promotes selectivity and efficiency toward C2 products by electrocatalytic CO2 reduction
The Cu electrode surface is reconstructed by a halide anion assisted method for promoting CO2 reduction.
Chem. Sci., 2020,11, 10698-10704
https://doi.org/10.1039/D0SC01202E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.139/content/NewImages/open-access-icon-orange.png)
How to polarise an interface with ions: the discrete Helmholtz model
The discrete nature of the charge carriers at polarised soft interfaces yields sharp potential profiles as well as concentration and potential independent capacitances.
Chem. Sci., 2020,11, 10807-10813
https://doi.org/10.1039/D0SC00685H
About this collection
2020 marks the 10th anniversary of Chemical Science and to celebrate we are publishing a number of special birthday issues, to recognise and thank members of our community who have been supporting the journal and publishing in Chemical Science since we launched ten years ago. Many of these individuals feature as authors in this collection and, looking to the future, we have combined this with inviting a selection of researchers who are closer to the beginning of their careers, and who are new to publishing in Chemical Science. We hope that you enjoy reading this selection of articles, and that we can continue to provide an open and inclusive venue for both groups of researchers for many years to come.