Themed collection Organic chemistry collection
Intramolecular Morita–Baylis–Hillman and Rauhut–Currier reactions. A catalytic and atom economic route for carbocycles and heterocycles
Intramolecular MBH and RC reactions: glorious past and future opportunities.
RSC Adv., 2015,5, 75923-75946
https://doi.org/10.1039/C5RA13611C
Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions
This review highlights the recent advances using deep eutectic solvents (DESs), deep eutectic ionic liquids (DEILs), low-melting mixtures (LMMs) or low transition temperature mixtures (LTTMs) as green media as well as catalysts in organic reactions.
RSC Adv., 2015,5, 48675-48704
https://doi.org/10.1039/C5RA05746A
New developments in direct functionalization of C–H and N–H bonds of purine bases via metal catalyzed cross-coupling reactions
This review provides a concise overview on the cross-coupling reactions in direct functionalization of purine bases in recent years.
RSC Adv., 2015,5, 44371-44389
https://doi.org/10.1039/C5RA04406E
Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.
RSC Adv., 2015,5, 15233-15266
https://doi.org/10.1039/C4RA15710A
A new C–C bond formation model based on the quantum chemical topology of electron density
Pseudodiradical structures and GEDT involved in the C–C single bond formation in non-polar, polar and ionic organic reactions.
RSC Adv., 2014,4, 32415-32428
https://doi.org/10.1039/C4RA04280H
Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides
Nucleoside analogues have attracted much attention due to their potential biological activities.
RSC Adv., 2014,4, 18558-18594
https://doi.org/10.1039/C3RA47911K
Recent advances in 4(3H)-quinazolinone syntheses
The new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones have been summarized.
RSC Adv., 2014,4, 12065-12077
https://doi.org/10.1039/C4RA00351A
Recent developments in palladium catalysed carbonylation reactions
Carbonylation reactions with a special emphasis on catalyst–product separation techniques are reviewed and discussed.
RSC Adv., 2014,4, 10367-10389
https://doi.org/10.1039/C3RA46273K
Recent development of direct asymmetric functionalization of inert C–H bonds
This review summarized recent development (contributions after 2009) in the area of direct catalytic asymmetric functionalization reactions of inert C–H bonds.
RSC Adv., 2014,4, 6173-6214
https://doi.org/10.1039/C3RA46996D
Understanding short-side-chain perfluorinated sulfonic acid and its application for high temperature polymer electrolyte membrane fuel cells
We summarize the properties of short-side-chain perfluorinated sulfonic acid membranes and provide insight into its micro-morphologies, mass diffusion and enhanced proton transportation.
RSC Adv., 2014,4, 3944-3965
https://doi.org/10.1039/C3RA43735C
Glutaraldehyde in bio-catalysts design: a useful crosslinker and a versatile tool in enzyme immobilization
Glutaraldehyde is one of the most widely used reagents in the design of biocatalysts.
RSC Adv., 2014,4, 1583-1600
https://doi.org/10.1039/C3RA45991H
Recent advances in the Cu(I)-catalyzed azide–alkyne cycloaddition: focus on functionally substituted azides and alkynes
The review is focused on synthetic applications of functionally substituted azides and terminal alkynes in the CuAAC combined with other transformations, such as multicomponent reactions, cross-coupling reactions, different cyclizations, etc.
RSC Adv., 2013,3, 16212-16242
https://doi.org/10.1039/C3RA42482K
Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions
This review highlights the progress in transition-metal-free carbon–carbon and carbon–heteroatom bond forming reactions, focusing on base and iodonium oxidant assisted inter- and intramolecular cross-couplings.
RSC Adv., 2013,3, 11957-11986
https://doi.org/10.1039/C3RA40813B
Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts
A metal-free approach for the C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts was developed.
RSC Adv., 2015,5, 36390-36393
https://doi.org/10.1039/C5RA03819G
N-heterocyclic carbene-catalysed pentafluorophenylation of aldehydes
N-heterocyclic carbenes have been utilized as highly efficient organocatalysts to catalyse multifluorophenylation of aldehydes with fluorinated aryltrimethylsilanes to afford the corresponding adducts in 49–99% yields.
RSC Adv., 2015,5, 35513-35517
https://doi.org/10.1039/C5RA05487G
Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems
Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex γ-lactone backbone.
RSC Adv., 2015,5, 26972-26976
https://doi.org/10.1039/C5RA01254F
Selective CO2 adsorption in a porphyrin polymer with benzimidazole linkages
A new nanoporous porphyrin-based benzimidazole linked polymer, PBILP, was synthesized.
RSC Adv., 2015,5, 10960-10963
https://doi.org/10.1039/C4RA15086D
A general route to 1,5-disubstituted 1,2,3-triazoles with alkyl/alkyl, alkyl/aryl, aryl/aryl combinations: a metal-free, regioselective, one-pot three component approach
An experimentally simple one-pot reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields by combining vinyl sulfones, sodium azide and alkyl bromides, -tosylates, -mesylates or aryl amines, -iodides is reported.
RSC Adv., 2014,4, 9275-9278
https://doi.org/10.1039/C3RA47062H
L-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature
L-Proline catalyzed one-pot synthesis of gem-(β-dicarbonyl)-arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C–H activated acids on grinding them together under solvent-free conditions at room temperature.
RSC Adv., 2014,4, 7380-7388
https://doi.org/10.1039/C3RA44568B
ConMedNP: a natural product library from Central African medicinal plants for drug discovery
Lipinski violations and compound distribution in ConMedNP by plant family of origin.
RSC Adv., 2014,4, 409-419
https://doi.org/10.1039/C3RA43754J
Synthesis of γ-valerolactone using a continuous-flow reactor
This study describes the heterogeneous catalysed continuous synthesis of γ-valerolactone (GVL) using a continuous-flow reactor, H-Cube® and H-Cube Pro™, equipped with 5% Ru/C, 10% Pd/C and RANEY® Ni CatCart®.
RSC Adv., 2013,3, 16283-16287
https://doi.org/10.1039/C3RA43032D
New generation biofuels: γ-valerolactone into valeric esters in one pot
Copper supported on amorphous SiO2–ZrO2 was found to be an active catalyst for the one pot transformation of γ-valerolactone to ethyl and pentyl valerate.
RSC Adv., 2013,3, 1302-1306
https://doi.org/10.1039/C2RA23043G
Facile synthesis and photovoltaic applications of a new alkylated bismethano fullerene as electron acceptor for high open circuit voltage solar cells
In this work, a bis-adduct C60 derivative was facilely synthesized using an alkyl solubilizing group. This semiconductor offers a higher LUMO level compared to PCBM, which resulted in a significantly enhanced Voc of 0.73 V in organic solar cells.
RSC Adv., 2015,5, 64724-64730
https://doi.org/10.1039/C5RA10089E
Relevance of the acidic 1-butyl-3-methylimidazolium hydrogen sulphate ionic liquid in the selective catalysis of the biomass hemicellulose fraction
The process represents a sustainable and selective approach of biomass hemicellulose fraction transformation into pivot chemicals, such as xylose and furfural, solely mediated by the acidic [bmim][HSO4] ionic liquid.
RSC Adv., 2015,5, 47153-47164
https://doi.org/10.1039/C5RA07159C
Efficient adsorption of Europhtal onto activated carbon modified with ligands (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (M) and (1E,2E)-1,2-bis(pyridin-3-ylmethylene)hydrazine (SCH-4); response surface methodology
Porous activated carbon was modified with (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (M) and (1E,2E)-1,2-bis(pyridin-3-ylmethylene)hydrazine (SCH-4).
RSC Adv., 2015,5, 42376-42387
https://doi.org/10.1039/C5RA03622D
Speed versus stability – structure–activity effects on the assembly of two-component gels
Modifying the peripheral peptides dramatically changes the time required for gelation under ambient conditions, whilst an enthalpy–entropy balance means that as the temperature increases, the thermal stability of the gels is very similar.
RSC Adv., 2015,5, 27190-27196
https://doi.org/10.1039/C5RA01256B
Novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications
Three-dimensional polymer scaffolds with interconnected porous structures were fabricated by thermally induced phase separation of novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid).
RSC Adv., 2015,5, 21301-21309
https://doi.org/10.1039/C5RA00508F
Organocatalysis by p-sulfonic acid calix[4]arene: a convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water
An efficient and eco-friendly method is reported for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using p-sulfonic acid calix[4]arene as a recyclable organocatalyst in excellent yields in water at room temperature.
RSC Adv., 2015,5, 7755-7760
https://doi.org/10.1039/C4RA16374E
Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrroles
Deep eutectic solvent (DES) based on choline chloride and malonic acid was applied as catalyst and reaction medium for synthesis of pyrroles by one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane.
RSC Adv., 2015,5, 7720-7728
https://doi.org/10.1039/C4RA13577F
Hyperattenins A–I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy
Nine new bioactive polyprenylated acylphloroglucinols were isolated from the aerial parts of Hypericum attenuatum Choisy.
RSC Adv., 2015,5, 5277-5287
https://doi.org/10.1039/C4RA11675E
Can elongation of the π-system in triarylamine derived sensitizers with either benzothiadiazole and/or ortho-fluorophenyl moieties enrich their light harvesting efficiency? – a theoretical study
This study established that elongation of the π-system in a series of hypothetical triphenylamine dyes by the judicious placement either a fluorophenyl or benzothiadiazole group, or a combination of both groups, results in improved light harvesting efficiency in DSSCs.
RSC Adv., 2015,5, 3978-3998
https://doi.org/10.1039/C4RA09914A
Benzimidazolin-2-ylidene N-heterocyclic carbene complexes of ruthenium as a simple catalyst for the N-alkylation of amines using alcohols and diols
Simple non-chelating ruthenium benzimidazolin-2-ylidene complexes as efficient N-alkylation catalysts using alcohols and diols following a hydrogen borrowing strategy.
RSC Adv., 2015,5, 4434-4442
https://doi.org/10.1039/C4RA15398G
Magnesium complexes bearing N,N-bidentate phenanthrene derivatives for the stereoselective ring-opening polymerization of rac-lactides
Magnesium complexes based on N,N-bidentate phenanthrene derivatives derived from Schiff bases were synthesized and investigated as catalysts for rac-lactide polymerization.
RSC Adv., 2015,5, 440-447
https://doi.org/10.1039/C4RA12548G
Journey on greener pathways: use of Euphorbia condylocarpa M. bieb as reductant and stabilizer for green synthesis of Au/Pd bimetallic nanoparticles as reusable catalysts in the Suzuki and Heck coupling reactions in water
This work reports on the green synthesis of Au/Pd bimetallic nanoparticles by using Euphorbia condylocarpa M. bieb root extract and their application as separable catalysts for ligand-free Suzuki and Heck coupling reactions in water.
RSC Adv., 2014,4, 43477-43484
https://doi.org/10.1039/C4RA07173E
Biodiesel production, characterization, engine performance, and emission characteristics of Malaysian Alexandrian laurel oil
This article studies the production and characterization of Malaysian Alexandrian laurel oil and the effect of common blends on engine performance and emissions.
RSC Adv., 2014,4, 17787-17796
https://doi.org/10.1039/C3RA47954D
Production of γ-valerolactone from biomass-derived compounds using formic acid as a hydrogen source over supported metal catalysts in water solvent
Au/ZrO2 is a reusable and acid-tolerant catalyst for production of γ-valerolactone from biomass-derived compounds using formic acid as hydrogen source.
RSC Adv., 2014,4, 10525-10530
https://doi.org/10.1039/C3RA47580H
A near-infrared fluorescent sensor for selective detection of cysteine and its application in live cell imaging
We develop a NIR fluorescent sensor based on cyanine dyes for the selective detection of Cys.
RSC Adv., 2014,4, 8360-8364
https://doi.org/10.1039/C3RA47116K
Synthesis and characterization of novel bio-based benzoxazines from eugenol
Polybenzoxazines are phenolic-like materials that possess dimensional and thermal stability, and they release no by-products during their polymerization.
RSC Adv., 2014,4, 7959-7966
https://doi.org/10.1039/C3RA46582A
Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin
The peroxyl radical scavenging activity of cyclic 3-hydroxymelatonin (3-OHM) has been investigated and compared with that melatonin, AMK, AFMK, and Trolox. It is proposed that the protective effects of melatonin against peroxyl radicals become important after being metabolized into 3-OHM.
RSC Adv., 2014,4, 5220-5227
https://doi.org/10.1039/C3RA44604B
LDA-promoted asymmetric synthesis of β-trifluoromethyl-β-amino indanone derivatives with virtually complete stereochemical outcome
Reactions of 1-indanones and (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine were developed, which used catalytic amounts of LDA with complete stereochemical outcome and excellent yields.
RSC Adv., 2014,4, 4763-4768
https://doi.org/10.1039/C3RA45773G
Imidazole as organocatalyst for multicomponent reactions: diversity oriented synthesis of functionalized hetero- and carbocycles using in situ-generated benzylidenemalononitrile derivatives
The multicomponent reaction of malononitrile, aldehyde and naphthol/4-hydroxycoumarine/2-hydroxynaphthoquinone/kojic acid/enolizable ketone or thiol in the presence of imidazole provides very interesting molecular diversity.
RSC Adv., 2014,4, 3732-3741
https://doi.org/10.1039/C3RA45252B
Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes
An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed.
RSC Adv., 2014,4, 8-17
https://doi.org/10.1039/C3RA45765F
About this collection
This collection is Guest Edited by Editorial Board Member Professor Russell Cox . It contains selected reviews, communications and full papers published from 2013 to 2015. The collection brings together articles with the continued aim of inspiring new authors to submit their best work to the journal, but also to highlight great work by regular authors. These articles are already among the most highly cited works in the journal, illustrating their impact. The subject areas include those traditionally regarded as organic, such as synthesis, catalysis, heterocyclic and organometallic chemistry, natural products chemistry and method development. In addition, it also includes articles from overlapping areas including green chemistry, fuel production, ionic solvents and materials chemistry, where there is a strong organic and biological component. Underpinning all are theoretical and computational studies. Finally, emerging areas such as photovoltaics and chemical biology have strong organic chemistry foundations and also find a natural home in this RSC Advances collection. Overall, this selection aims to illustrate the breadth, depth and impact of papers published in RSC Advances in the area of organic chemistry and stimulate new submissions in these and allied areas.