Issue 17, 2005

Rational design of new bifunctional inhibitors of type II dehydroquinase

Abstract

Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.

Graphical abstract: Rational design of new bifunctional inhibitors of type II dehydroquinase

Supplementary files

Article information

Article type
Communication
Submitted
23 mai 2005
Accepted
19 jul 2005
First published
01 ago 2005

Org. Biomol. Chem., 2005,3, 3102-3104

Rational design of new bifunctional inhibitors of type II dehydroquinase

M. D. Toscano, K. A. Stewart, J. R. Coggins, A. J. Lapthorn and C. Abell, Org. Biomol. Chem., 2005, 3, 3102 DOI: 10.1039/B507156A

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