Issue 17, 2005

First total synthesis of the biologically active 2,7-dioxygenated tricyclic carbazole alkaloids 7-methoxy-O-methylmukonal, clausine H (clauszoline-C), clausine K (clauszoline-J) and clausine O

Abstract

Using the iron-mediated arylamine cyclization as the key step we have achieved a short and highly efficient access to the biologically active 2,7-dioxygenated tricyclic carbazole alkaloids 7-methoxy-O-methylmukonal, clausine H (clauszoline-C), clausine K (clauszoline-J) and clausine O.

Graphical abstract: First total synthesis of the biologically active 2,7-dioxygenated tricyclic carbazole alkaloids 7-methoxy-O-methylmukonal, clausine H (clauszoline-C), clausine K (clauszoline-J) and clausine O

Supplementary files

Article information

Article type
Communication
Submitted
01 Jun 2005
Accepted
28 Jul 2005
First published
03 Aug 2005

Org. Biomol. Chem., 2005,3, 3099-3101

First total synthesis of the biologically active 2,7-dioxygenated tricyclic carbazole alkaloids 7-methoxy-O-methylmukonal, clausine H (clauszoline-C), clausine K (clauszoline-J) and clausine O

O. Kataeva, M. P. Krahl and H. Knölker, Org. Biomol. Chem., 2005, 3, 3099 DOI: 10.1039/B507660A

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