Issue 17, 2005
From the journal:

Organic & Biomolecular Chemistry

Rational design of new bifunctional inhibitors of type II dehydroquinase†

Miguel D. Toscano,a   Kirsty A. Stewart,b   John R. Coggins,c   Adrian J. Lapthornb  and  Chris Abell*a  

* Corresponding authors

a University Chemical Laboratory, Lensfield Road, Cambridge, UK
E-mail: ca26@cam.ac.uk
Fax: 44 1223 336362
Tel: 44 1223 336405

b Dept. of Chemistry, Joseph Black Building, University of Glasgow, Glasgow, UK

c Institute of Biomedical and Life Sciences, Division of Biochemistry and Molecular Biology, University of Glasgow, Glasgow, UK

Abstract

Selective inhibitors of type II dehydroquinase were rationally designed to explore a second binding-pocket in the active-site. The molecular modelling, synthesis, inhibition studies and crystal structure determination are described.

Graphical abstract: Rational design of new bifunctional inhibitors of type II dehydroquinase

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Article information

DOI
https://doi.org/10.1039/B507156A
Article type
Communication
Submitted
23 mai 2005
Accepted
19 jul 2005
First published
01 ago 2005

Org. Biomol. Chem., 2005,3, 3102-3104

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Rational design of new bifunctional inhibitors of type II dehydroquinase

M. D. Toscano, K. A. Stewart, J. R. Coggins, A. J. Lapthorn and C. Abell, Org. Biomol. Chem., 2005, 3, 3102 DOI: 10.1039/B507156A

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