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Themed collection Immunotherapy

14 items
Editorial

Framing technology challenges associated with improving cancer immunotherapies

Thought leader Jim Heath introduces the Lab on a Chip Immunotherapy thematic collection.

Graphical abstract: Framing technology challenges associated with improving cancer immunotherapies
From the themed collection: Immunotherapy
Tutorial Review

Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy

Immunotherapy is a powerful therapeutic approach able to re-educate the immune system to fight cancer. In this scenario, tumor-on-chip can help to choose the right immunotherapeutic treatment.

Graphical abstract: Tumor-on-a-chip platforms to study cancer–immune system crosstalk in the era of immunotherapy
From the themed collection: Lab on a Chip Recent HOT Articles
Open Access Critical Review

Recent advances in microfluidic technologies for cell-to-cell interaction studies

Microfluidic cell cultures are ideally positioned to become the next generation of in vitro diagnostic tools for biomedical research, where key biological processes such as cell signalling and dynamic cell-to-cell interactions can be reliably analysed under reproducible physiological cell culture conditions.

Graphical abstract: Recent advances in microfluidic technologies for cell-to-cell interaction studies
From the themed collection: Immunotherapy
Paper

A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues

We developed a multilayered blood vessel/tumor tissue chip (MBTC) that allows systematic investigation on T cell tumor infiltration. Key characteristics of T cell dynamics in tumor microenvironments are recapitulated in the MBTCs.

Graphical abstract: A multilayered blood vessel/tumor tissue chip to investigate T cell infiltration into solid tumor tissues
From the themed collection: Immunotherapy
Paper

Machine learning-aided quantification of antibody-based cancer immunotherapy by natural killer cells in microfluidic droplets

Comparative proteomic profiling and development of convolution neural network algorithm for quantifying discrete target interaction by engineered NK cells in microfluidic droplets.

Graphical abstract: Machine learning-aided quantification of antibody-based cancer immunotherapy by natural killer cells in microfluidic droplets
From the themed collection: Immunotherapy
Paper

Droplet encapsulation improves accuracy of immune cell cytokine capture assays

In-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.

Graphical abstract: Droplet encapsulation improves accuracy of immune cell cytokine capture assays
From the themed collection: Immunotherapy
Paper

MATE-Seq: microfluidic antigen-TCR engagement sequencing

Barcoded nanoparticles and an integrated DLD and droplet generator device are used to purify and sequence rare antigen-specific T cells.

Graphical abstract: MATE-Seq: microfluidic antigen-TCR engagement sequencing
From the themed collection: Immunotherapy
Paper

Single cell arrays of hematological cancer cells for assessment of lymphocyte cytotoxicity dynamics, serial killing, and extracellular molecules

A new microwell assays to asses lymphocyte cytotoxicity against hematological cancer cells.

Graphical abstract: Single cell arrays of hematological cancer cells for assessment of lymphocyte cytotoxicity dynamics, serial killing, and extracellular molecules
From the themed collection: Immunotherapy
Paper

Microfluidic on-demand engineering of exosomes towards cancer immunotherapy

3D printing-based facile microfabrication of a microfluidic culture chip integrates harvesting, antigenic modification, and photo-release of surface engineered exosomes in one workflow, which enables rapid and real-time production of therapeutic exosomes for advancing cancer immunotherapy.

Graphical abstract: Microfluidic on-demand engineering of exosomes towards cancer immunotherapy
From the themed collection: Immunotherapy
Paper

Functional TCR T cell screening using single-cell droplet microfluidics

Droplet-based single cell platform allows functional screening and sorting of desirable TCR T cells to accelerate development of adoptive T cell therapies.

Graphical abstract: Functional TCR T cell screening using single-cell droplet microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Open Access Paper

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

Microfluidic culture has the potential to revolutionize cancer diagnosis and therapy.

Graphical abstract: 3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting

Our results demonstrate that multi-directional magnetic ratcheting offers a unique separation system for dealing with clinical samples that contain either rare cells or significantly small volumes.

Graphical abstract: Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting
From the themed collection: Immunotherapy
Paper

A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions

A system for perfusing and interacting tumor fragments and immune cells and testing drug response with image analytics is reported.

Graphical abstract: A multiplexed microfluidic system for evaluation of dynamics of immune–tumor interactions
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers

An OET-based LabChip was developed to provide a stable and static culture μ-environment for cancer immunotherapy studies. The TiOPc-based OET facilitates the studies of cell–cell interaction resulting in apoptotic progress of cancer cells.

Graphical abstract: Cancer immunotherapy μ-environment LabChip: taking advantage of optoelectronic tweezers
From the themed collection: Immunotherapy
14 items

About this collection

A collection of recent reviews and research papers on the topic of immunotherapy and immunoengineering published in Lab on a Chip and curated by the Lab on a Chip Editorial Board. 

This topic area is currently the focus of a thematic collection in this field, led by Thought leader James R. Heath. More details about how to submit to the collection can be found at rsc.li/immunotherapy-blog.


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