Issue 23, 2022

Metal–organic frameworks loaded Au nanozymes with enhanced peroxidase-like activity for multi-targeted biodetection

Abstract

Size and surface effects definitely play an important role in promoting the enzyme-like catalytic activity of metal nanozymes. However, monodisperse small-size nanozymes require surface modification to avoid agglomeration, which largely limits their catalytic activity. In this work, a zirconium-based metal organic framework (UiO-66) with high chemical stability and porosity was applied as a carrier, on which uniform Au nanoparticles (NPs) were successfully loaded, forming Au/UiO-66 nanocomposites. Benefiting from the naked and active surface of the distributed Au NPs, Au/UiO-66 exhibited prominently enhanced peroxidase activity as well as good performance and stability. Inspired by the significant peroxidase activity of Au/UiO-66 and the distinct inhibitory effect of biological substances on peroxidase activity, a multi-targeted analytical platform was designed and established. The results proved that the developed platform realized accurate and effective detection for glucose, dopamine and HS with a limit of detection (LOD) of 0.033 mM, 0.0022 mM and 0.0016 mM, respectively.

Graphical abstract: Metal–organic frameworks loaded Au nanozymes with enhanced peroxidase-like activity for multi-targeted biodetection

Supplementary files

Article information

Article type
Paper
Submitted
26 jul 2022
Accepted
26 sep 2022
First published
27 sep 2022
This article is Open Access
Creative Commons BY-NC license

Mater. Adv., 2022,3, 8557-8566

Metal–organic frameworks loaded Au nanozymes with enhanced peroxidase-like activity for multi-targeted biodetection

Q. Liu, H. Wang, Q. Yang, Y. Tong and W. He, Mater. Adv., 2022, 3, 8557 DOI: 10.1039/D2MA00844K

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