Themed collection 2025 RSC Advances Popular Advances Collection

The Stille reaction, a pivotal palladium-catalyzed cross-coupling, continues to drive advancements in the total synthesis of highly complex natural products, pharmaceuticals, and functional materials.

A concise overview of recent advances (2021–2025) in nitrone chemistry, emphasizing metal-catalyzed and metal-free cycloadditions, emerging photoredox and asymmetric strategies, and their impact on constructing diverse heterocycles.

Nanotechnology has become a fast-growing field, and to prepare metallic nanoparticles for clinics or chemical establishments, it is mandatory that a cost-effective, eco-friendly technique be developed, using all nontoxic and renewable resources.

Alkyl polyglycosides (APGs), synthesized from sugars and fatty alcohols, exhibit low surface tension, good foam, and biodegradability. This review systematically covers their structure–property relationships, synthetic methodologies and applications.

Pyrimidine C–H activation can be efficiently achieved through three complementary strategies: metal-catalyzed, metal-free, and photochemical approaches enabling direct functionalization and structural diversification of heteroaromatic frameworks.

The preparation of cyclic compounds has received a significant amount of attention, because of their extensive presence in natural products, bioactive molecules, and materials science.

Depending on the chemical origins and pathways, mineral sensation arises from three main groups: metal, sulfur, and metal-catalyzed that trigger distinct subsets of sensory receptors so that we are able to sense characteristic mineral tastes/aromas.

This comprehensive review delves into the intricate world of triazines, including their structures and the chemical diversity of their isomers.

5-Amino- and 6-amino-uracil derivatives are used as precursors in the synthesis of various heterocyclic compounds, which have attracted great interest because of their potent biological activities and therapeutic uses.

The current review summarizes the recent applications of Corey–Chaykovsky reaction toward the total synthesis of several classes of natural products i.e., alkaloids, terpenoids, depsipeptides, polyketides and amino acids, etc.

Recent advances in ullazine derivatives have enabled precise electronic tuning, yielding highly conjugated materials with enhanced light-harvesting and charging transport properties for use in organic photovoltaics and dye-sensitized solar cells.

Mechanism of polymeric nanoparticles in targeting infection and cancer sites.

This review explores PTSA's based DES diverse applications and highlights its potential.

Quinoline plays a crucial role in drug development and pharmaceutical synthesis. This review highlights quinoline-based medications and their therapeutic potential, especially for malaria and cancer, impacting millions worldwide.

The integration of s-triazine and BODIPY scaffolds has emerged as a versatile strategy for developing multifunctional conjugates with tailored photophysical and biological properties.

L-Proline organocatalyst immobilization (impregnation, intercalation, grafting) enables recovery and reuse in large-scale asymmetric transformations.

Daucus carota (carrot) roots exhibit potential as biocatalysts due to their broad substrate compatibility, reducing reliance on toxic reagents and energy-intensive processes. This review discusses the use of D. carota in chiral alcohol synthesis.

This review focuses mainly on the signature of click chemistry (CuAAC and SPAAC) in advanced techniques for cancer therapeutics.

Furonaphthoquinones and their dihydro derivatives have attracted significant attention due to their diverse pharmacological activities.

An integrated LC-MS/MS-based strategy for comprehensive clarification of metabolic profiling of loganin in vivo and tissue distribution.

Novel salicylic acid derivatives with dual anti-inflammatory and anti-arthritic potentials.

A series of eighteen pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidine derivatives were designed and synthesized as novel tacrine-like AChE inhibitors.

Photodynamic therapy (PDT) offers exceptional spatial and temporal precision, minimal invasiveness, and negligible side effects.

Colon cancer remains a major global health burden characterized by uncontrolled proliferation, oxidative stress, and poor responsiveness to conventional therapies, underscoring the need for biocompatible and targeted nanotherapeutic interventions.

Green-synthesized carbon dots (B-CQDs) from coffee grounds detect tetracycline via concentration-dependent fluorescence quenching. They offer sensitive, selective, and eco-friendly analysis in complex water matrices.

This study presents the fabrication and characterization of 3D-printed biodegradable composite filters for the removal of cationic dyes from aqueous solutions.

We demonstrate an easy and technologically relevant approach for the successful growth of monolayer and multilayer graphene layers on polycrystalline nickel (Ni-poly) substrates using liquid ethanol (C₂H₅OH) as a carbon precursor.

Highly conductive and oxidation resistant copper nanowires synthesized via hydrothermal method. The influence of capping agent and reducting agent concentration was investigated.

A series of 1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitriles were synthesized and characterized. The compounds showed notable antimicrobial activity against major bacterial strains and exhibited antioxidant potential in the DPPH assay.

Phosphonates 1a–l and 6a–m were prepared using the Kabachnik-Fields multicomponent reaction. The antioxidant activity of these compounds was evaluated and found to be of the same order as that of ascorbic acid and ellagic acid.

Integrated SELEX-Simulation pipeline for LPS-specific aptamer discovery.

Development of a composite film by incorporating Few-Layer Graphene (FLG) within a gelatin–chitosan polymer matrix for enhanced drug delivery

A novel method for synthesis of aliphatic α-hydroxy acids is achieved via electrocarboxylation of aldehydes with CO₂ in an undivided cell with stable carbon based electrodes.

Novel synthesized ionic liquids incorporating a sulfonamide moiety with dual applications as petrocollecting/dispersing agents and insecticidal agents.

Combination of plasmonic size-dependent near-field enhancement and electron transfer with slow photon effects in Au/WO₃ inverse opal photoanodes boosts PEC and photoelectrocatalytic performance.

Polyether/Li_1+xAl_xGe_2−x(PO₄)₃ hybrid electrolytes were investigated to assess the effect of inorganic crystallinity, and exhibited low-temperature ionic conductivity and reduced grain boundary resistance.

The direct and atom economic synthesis of azulenyl-substituted gold(I) carbene complexes, based on the modular template synthesis using gold(I) isonitrile complexes and amine nucleophiles, is presented.

Plastic-binding peptides integrated into programmable multienzyme scaffolds validate binding capacity but reveal off-target binding challenges for rational scaffold design.

This study investigates the molecular transformation of hydrocarbons under gamma radiation in the presence of nanostructured sodium bentonite clay.

The systematic modifications of the haloquinolones, lead to different packing structures by balancing the weak interactions, thus serving as representative examples for designing solid-state active APIs through the crystal engineering approach.

The (R)-pyrrolidin-2-yl-substituted dehydroabietyl squaramide served as an efficient organocatalyst for the asymmetric Michael addition of cyclohexanone to β-nitrostyrenes with high yields and good to excellent stereoselectivity.

Designing a simple and green experimental protocol for the synthesis of stable and small Cu(0) and Sn(0) nanospheres using L-ascorbic acid as the reducing agent under mild conditions.

The aerobic oxidation of 2,3-dihydroquinazolin-4(1H)-ones and hantzsch 1,4-dihydropyridines in the presence of layered double hydroxides as laccase mimicking nanozymes is describe.

Nitrogen- and sulfur-co-doped Ti₂CO₂ MXene enhances adsorption and conductivity, effectively suppressing the polysulfide shuttle effect, making it a promising anchoring material for next-generation room-temperature sodium–sulfur batteries.

A novel hybrid strategy for the enantioselective synthesis of unnatural α-amino acids was developed. This approach provides a platform for synthesizing enantiomerically enriched unnatural α-amino acids with potential bioactivity.

Thirteen xanthone derivatives were synthesized through the structural modification of toxyloxanthone C (1) and macluraxanthone (2). The acetylated and brominated derivatives of 1 exhibited enhanced anticancer and antibacterial activities.

Synthesis of functionalized 1,3-indandione containing spirocyclopentanes has been achieved in a highly diastereoselective manner in presence of catalytic amount of DABCO by the reaction of 2-(2′-ketoalkyl)-1,3-indandiones with nitrostyrenes.

AI-Nano-DIHM enables real-time, in situ 4D characterization and automated classification of black carbon, carbon nanotubes, and graphite aerosols in air and aqueous environments.

This investigation presents a multicomponent reaction involving acetylacetone, aldehydes, guanidine, and activated acetylenic compounds in water at room temperature employing small quantities of Cu/ZnO@GO as nanocatalyst.

Twenty 3-methylenamino-4(3H)-quinazolone derivatives were synthesized via imine formation. Compounds 5, 6, and 7 showed potent cytotoxicity against RD and MDA-MB-231, low toxicity to normal cells, and strong EGFR binding, with good ADMET profiles.

A series of novel fluorescent DNA-binding pyrylium dyes is developed, and the mechanism of their fluorogenicity is explored computationally.

A novel lithium extraction composite adsorbent was prepared by loading aluminum salt adsorbent onto molecular sieve LiAl-LDHS/ZSM-5 for the first time.

We report the synthesis of 1H-benzo[d][1,3]oxazine-2,4-diones from 2-aminobenzoic acids, using fluorenylmethyloxycarbonyl (Fmoc), benzyloxycarbonyl (Cbz) and ethyloxycarbonyl (EtOCO) groups as the source of carbonyloxy group, and thionyl chloride.

Streptavidin binding to DNA origami-supported high-density biotin arrays is investigated for selected experimental parameters. While bidentate binding and steric hindrance can be minimized, molecular crowding limits the binding yields in 2D arrays.

Cubic and monoclinic WO₃ nanoplates were synthesized from WO₃·nH₂O via calcination at 200 °C for 2 h. The monoclinic WO₃-based sensor showed the highest response of 1329.3 to 2.5 ppm NO₂ at 150 °C.

A dual-functional {SnEr}-MOF (TYUT-13a) with hierarchical porosity enables >98% CO₂ cycloaddition conversion (4 h, 65 °C, 1 atm) and >97% Knoevenagel yield, outperforming monometallic MOFs via synergistic Lewis acid (Sn/Er) and basic (N) sites.

4-Hydroxyacetophenone derivatives were synthesized and characterized. These compounds exhibited promising cholinesterase inhibition, supported by docking and DFT studies that revealed strong binding interactions and favorable electronic properties.

A library of (teraryl, quateraryl, hexaryl) polyaryl unnatural amino acid motifs is generated via successive stereoselective C(sp³)–H arylation and Suzuki coupling. These molecules may be useful for future proteomimetic design (α-helix mimetics).

D-A3 and A3-C6 with high activity, low toxicity and good stability were synthesized by modifying American oyster defensin analogue A3 with D-amino acid or a triazole ring. This study will provide new candidate drugs against microbial infection.

Gd₃Ga₅O₁₂:Tb single-crystalline films grown by liquid phase epitaxy represent a viable solution for scintillators providing high efficiency and sub-μm spatial resolution for X-ray imaging.

This study focuses on the evaluation of synthetic coumarin hybrids as potential SARS-CoV-2 inhibitors.

Novel niclosamide analogs (LSP) were synthesized via successive paired electrolysis of niclosamide (NIC) in the presence of arylsulfinic acids. This work presents a green method under mild conditions in a one-pot process.

The new extraction process significantly improves the extraction of Molybdenum-99 hot atoms/Tc-99m

A 1,1′-biazulenyl-2,2′-diol (“1,1′-BAzOL”) has been prepared in enantiopure form. The barrier to racemisation of this 1,1′-BAzOL has been determined and synthesis of an analogous 2,2′-bis(phosphonate) has also been achieved.

An efficient radical alkylative annulation/arylation of N-(arylsulfonyl)acrylamide with 4-alkyl-1,4-dihydropyridines (DHP) was developed for synthesizing all-carbon quaternary-centered β-alkyl amides.

This study reports a metal-free, three-component synthesis of substituted indolyl-1,3,4-thiadiazole amines, their functionalization into diverse N-heterocycles, and theoretical evaluation via DFT analysis.

Investigation and characterization of mineral phases in dental enamel using electron energy loss spectroscopy.

The study presents a comparison of green synthetic methods for N-acyl pyrazoles, which show solid-state luminescent properties due to the AIE phenomenon, using aromatic carbohydrazide derivatives and 1,3-diketones as starting materials.

Thermal batteries are widely used in defense and emergency fields due to their long storage periods and high power characteristics.

Levulinic ester ketals (LEKs) are carbohydrate-derived renewable chemicals with potential applications as chemical building blocks, fuel additives, solvents, monomers, and plasticizers.